Genetic associations with a fever after measles-containing vaccines
Children have elevated fever risk 1 to 2 weeks after the first dose of a measles-containing vaccine (MCV), which is likely affected by genetic, immunologic, and clinical factors. Fever after MCV is associated with febrile seizures, though may also be associated with higher measles antibody titers. T...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2021-06-01
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| Series: | Human Vaccines & Immunotherapeutics |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/21645515.2020.1849520 |
| _version_ | 1797677199188295680 |
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| author | Nicola P. Klein Ousseny Zerbo Kristin Goddard Weiqi Wang Alison E. Fohner Amy Wiesner Vida Shokoohi John Coller Karin Bok Hayley A. Gans |
| author_facet | Nicola P. Klein Ousseny Zerbo Kristin Goddard Weiqi Wang Alison E. Fohner Amy Wiesner Vida Shokoohi John Coller Karin Bok Hayley A. Gans |
| author_sort | Nicola P. Klein |
| collection | DOAJ |
| description | Children have elevated fever risk 1 to 2 weeks after the first dose of a measles-containing vaccine (MCV), which is likely affected by genetic, immunologic, and clinical factors. Fever after MCV is associated with febrile seizures, though may also be associated with higher measles antibody titers. This exploratory study investigated genetic and immunologic associations with a fever after MCV. Concurrent with a randomized Phase 3 clinical trial of 12–15-month-olds who received their first measles-mumps-rubella (MMR) vaccine in which parents recorded post-vaccination temperatures daily, we consented a subset to collect additional blood and performed human leukocyte antigens (HLA) typing. Association between fever 5–12 days after MMR (“MMR-associated”) and HLA type was assessed using logistic regression. We compared 42-day post-vaccination geometric mean titers (GMT) to measles between children who did and did not have fever using a t-test. We enrolled 86 children and performed HLA typing on 82; 13 (15.1%) had MMR-associated fever. Logistic regressions identified associations between MMR-associated fever and HLA Class I loci A-29:02 (P = .036), B-57:01 (P = .018), C-06:02 (P = .006), C-14:02 (P = .022), and Class II loci DRB1-15 (P = .045). However, Bonferroni's adjustment for multiple comparisons suggests that these associations could have been due to chance. Ninety-eight percent of children had protective antibody titers to measles; however, GMT was higher among those with fever compared with children without fever (P = .006). Fever after the measles vaccine correlated with genetic factors and higher immune response. This study suggests a possible genetic susceptibility to MMR-associated fever. |
| first_indexed | 2024-03-11T22:41:36Z |
| format | Article |
| id | doaj.art-32df1bf05abd4507abced85cd515de40 |
| institution | Directory Open Access Journal |
| issn | 2164-5515 2164-554X |
| language | English |
| last_indexed | 2024-03-11T22:41:36Z |
| publishDate | 2021-06-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj.art-32df1bf05abd4507abced85cd515de402023-09-22T08:51:52ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2021-06-011761763176910.1080/21645515.2020.18495201849520Genetic associations with a fever after measles-containing vaccinesNicola P. Klein0Ousseny Zerbo1Kristin Goddard2Weiqi Wang3Alison E. Fohner4Amy Wiesner5Vida Shokoohi6John Coller7Karin Bok8Hayley A. Gans9Kaiser Permanente Vaccine Study CenterUniversity of WashingtonKaiser Permanente Vaccine Study CenterStanford UniversityKaiser Permanente Vaccine Study CenterKaiser Permanente Vaccine Study CenterStanford UniversityStanford UniversityUS. Health and Human ServicesStanford UniversityChildren have elevated fever risk 1 to 2 weeks after the first dose of a measles-containing vaccine (MCV), which is likely affected by genetic, immunologic, and clinical factors. Fever after MCV is associated with febrile seizures, though may also be associated with higher measles antibody titers. This exploratory study investigated genetic and immunologic associations with a fever after MCV. Concurrent with a randomized Phase 3 clinical trial of 12–15-month-olds who received their first measles-mumps-rubella (MMR) vaccine in which parents recorded post-vaccination temperatures daily, we consented a subset to collect additional blood and performed human leukocyte antigens (HLA) typing. Association between fever 5–12 days after MMR (“MMR-associated”) and HLA type was assessed using logistic regression. We compared 42-day post-vaccination geometric mean titers (GMT) to measles between children who did and did not have fever using a t-test. We enrolled 86 children and performed HLA typing on 82; 13 (15.1%) had MMR-associated fever. Logistic regressions identified associations between MMR-associated fever and HLA Class I loci A-29:02 (P = .036), B-57:01 (P = .018), C-06:02 (P = .006), C-14:02 (P = .022), and Class II loci DRB1-15 (P = .045). However, Bonferroni's adjustment for multiple comparisons suggests that these associations could have been due to chance. Ninety-eight percent of children had protective antibody titers to measles; however, GMT was higher among those with fever compared with children without fever (P = .006). Fever after the measles vaccine correlated with genetic factors and higher immune response. This study suggests a possible genetic susceptibility to MMR-associated fever.http://dx.doi.org/10.1080/21645515.2020.1849520mmrmmrvvaccinegenetic factorsfeverantibodytiters |
| spellingShingle | Nicola P. Klein Ousseny Zerbo Kristin Goddard Weiqi Wang Alison E. Fohner Amy Wiesner Vida Shokoohi John Coller Karin Bok Hayley A. Gans Genetic associations with a fever after measles-containing vaccines Human Vaccines & Immunotherapeutics mmr mmrv vaccine genetic factors fever antibody titers |
| title | Genetic associations with a fever after measles-containing vaccines |
| title_full | Genetic associations with a fever after measles-containing vaccines |
| title_fullStr | Genetic associations with a fever after measles-containing vaccines |
| title_full_unstemmed | Genetic associations with a fever after measles-containing vaccines |
| title_short | Genetic associations with a fever after measles-containing vaccines |
| title_sort | genetic associations with a fever after measles containing vaccines |
| topic | mmr mmrv vaccine genetic factors fever antibody titers |
| url | http://dx.doi.org/10.1080/21645515.2020.1849520 |
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