Brainstem Alzheimer's-like pathology in the triple transgenic mouse model of Alzheimer's disease

Brainstem Alzheimer's-like pathology in the triple transgenic mouse model of Alzheimer's disease

The triple transgenic mouse (3xTgAD), harboring human APPSwe, PS1M146V and TauP301L genes, develops age-dependent forebrain intraneuronal Aβ and tau as well as extraneuronal plaques. We evaluated brainstem AD-like pathology using 6E10, AT8, and Alz50 antibodies and unbiased stereology in young and o...

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Bibliographic Details
Main Authors: Cassia R. Overk, Christy M. Kelley, Elliott J. Mufson
Format: Article
Language:English
Published: Elsevier 2009-09-01
Series:Neurobiology of Disease
Subjects:
Alzheimer's disease
Amyloid
Brainstem
Pathology
Stereology
Tau
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996109001399

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