4042 Enhancing Scientific Rigor, Reproducibility, and Reporting in Translational Science Training and Practice
OBJECTIVES/GOALS: Irreproducible and incompletely reported research lead to misallocated resources, wasted effort in pursing inappropriate avenues of investigation, and loss of public trust. To address this challenge, we employed a Team Science approach to create a multi-modal program to support Rig...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Cambridge University Press
2020-06-01
|
| Series: | Journal of Clinical and Translational Science |
| Online Access: | https://www.cambridge.org/core/product/identifier/S2059866120003878/type/journal_article |
| _version_ | 1811155085516865536 |
|---|---|
| author | Roger Vaughan Matthew Covey Michelle Romanick Anthony Carvalloza Barry S. Coller |
| author_facet | Roger Vaughan Matthew Covey Michelle Romanick Anthony Carvalloza Barry S. Coller |
| author_sort | Roger Vaughan |
| collection | DOAJ |
| description | OBJECTIVES/GOALS: Irreproducible and incompletely reported research lead to misallocated resources, wasted effort in pursing inappropriate avenues of investigation, and loss of public trust. To address this challenge, we employed a Team Science approach to create a multi-modal program to support Rigor, Reproducibility, and Reporting in Translational Science. METHODS/STUDY POPULATION: We conducted literature searches to reveal sources of irreproducibility and recommended corrective actions, invited leaders in the field to give lectures on opportunities to support reproducible science, and worked with the Rockefeller team science leadership group to instill an overarching rigor approach, infused into all training efforts. This multifaceted program was labeled R3 (R-cubed) for Enhancing Scientific Rigor, Reproducibility, and Reporting. RESULTS/ANTICIPATED RESULTS: Didactic Courses:
Introduction to Biostatistics and Critical Thinking – focus on pitfalls in inferential statistics, consequences of poor research, and errors in published research.Scientific Writing – teaches methods and procedures in writing to ensure reproducibility. Lecture SeriesEstablished nine lectures on topics related to R3, including Data Management, Statistical Methods, Genomic Analyses, Data Repositories, Data Sharing, Pharmacy Formulation, and e-lab notebooks. WebsiteCreating a comprehensive website as repository for research, methods, programs, updates, and improvements related to R3. KL2 Clinical Scholars Seminars and NavigationScholars participate in seminars and tutorials to discuss opportunities to improve R3 across the research life-course. |
| first_indexed | 2024-04-10T04:28:15Z |
| format | Article |
| id | doaj.art-32e0b4d9e53c4169b064b75e741eaf3f |
| institution | Directory Open Access Journal |
| issn | 2059-8661 |
| language | English |
| last_indexed | 2024-04-10T04:28:15Z |
| publishDate | 2020-06-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | Journal of Clinical and Translational Science |
| spelling | doaj.art-32e0b4d9e53c4169b064b75e741eaf3f2023-03-10T08:51:36ZengCambridge University PressJournal of Clinical and Translational Science2059-86612020-06-01413013010.1017/cts.2020.3874042 Enhancing Scientific Rigor, Reproducibility, and Reporting in Translational Science Training and PracticeRoger Vaughan0Matthew Covey1Michelle Romanick2Anthony Carvalloza3Barry S. Coller4Rockefeller UniversityRockefeller UniversityRockefeller UniversityRockefeller UniversityRockefeller UniversityOBJECTIVES/GOALS: Irreproducible and incompletely reported research lead to misallocated resources, wasted effort in pursing inappropriate avenues of investigation, and loss of public trust. To address this challenge, we employed a Team Science approach to create a multi-modal program to support Rigor, Reproducibility, and Reporting in Translational Science. METHODS/STUDY POPULATION: We conducted literature searches to reveal sources of irreproducibility and recommended corrective actions, invited leaders in the field to give lectures on opportunities to support reproducible science, and worked with the Rockefeller team science leadership group to instill an overarching rigor approach, infused into all training efforts. This multifaceted program was labeled R3 (R-cubed) for Enhancing Scientific Rigor, Reproducibility, and Reporting. RESULTS/ANTICIPATED RESULTS: Didactic Courses: Introduction to Biostatistics and Critical Thinking – focus on pitfalls in inferential statistics, consequences of poor research, and errors in published research.Scientific Writing – teaches methods and procedures in writing to ensure reproducibility. Lecture SeriesEstablished nine lectures on topics related to R3, including Data Management, Statistical Methods, Genomic Analyses, Data Repositories, Data Sharing, Pharmacy Formulation, and e-lab notebooks. WebsiteCreating a comprehensive website as repository for research, methods, programs, updates, and improvements related to R3. KL2 Clinical Scholars Seminars and NavigationScholars participate in seminars and tutorials to discuss opportunities to improve R3 across the research life-course.https://www.cambridge.org/core/product/identifier/S2059866120003878/type/journal_article |
| spellingShingle | Roger Vaughan Matthew Covey Michelle Romanick Anthony Carvalloza Barry S. Coller 4042 Enhancing Scientific Rigor, Reproducibility, and Reporting in Translational Science Training and Practice Journal of Clinical and Translational Science |
| title | 4042 Enhancing Scientific Rigor, Reproducibility, and Reporting in Translational Science Training and Practice |
| title_full | 4042 Enhancing Scientific Rigor, Reproducibility, and Reporting in Translational Science Training and Practice |
| title_fullStr | 4042 Enhancing Scientific Rigor, Reproducibility, and Reporting in Translational Science Training and Practice |
| title_full_unstemmed | 4042 Enhancing Scientific Rigor, Reproducibility, and Reporting in Translational Science Training and Practice |
| title_short | 4042 Enhancing Scientific Rigor, Reproducibility, and Reporting in Translational Science Training and Practice |
| title_sort | 4042 enhancing scientific rigor reproducibility and reporting in translational science training and practice |
| url | https://www.cambridge.org/core/product/identifier/S2059866120003878/type/journal_article |
| work_keys_str_mv | AT rogervaughan 4042enhancingscientificrigorreproducibilityandreportingintranslationalsciencetrainingandpractice AT matthewcovey 4042enhancingscientificrigorreproducibilityandreportingintranslationalsciencetrainingandpractice AT michelleromanick 4042enhancingscientificrigorreproducibilityandreportingintranslationalsciencetrainingandpractice AT anthonycarvalloza 4042enhancingscientificrigorreproducibilityandreportingintranslationalsciencetrainingandpractice AT barryscoller 4042enhancingscientificrigorreproducibilityandreportingintranslationalsciencetrainingandpractice |