An Intrinsic Mitochondrial Pathway Is Required for Phytic Acid-Chitosan-Iron Oxide Nanocomposite (Phy-CS-MNP) to Induce G<sub>0</sub>/G<sub>1</sub> Cell Cycle Arrest and Apoptosis in the Human Colorectal Cancer (HT-29) Cell Line

An Intrinsic Mitochondrial Pathway Is Required for Phytic Acid-Chitosan-Iron Oxide Nanocomposite (Phy-CS-MNP) to Induce G<sub>0</sub>/G<sub>1</sub> Cell Cycle Arrest and Apoptosis in the Human Colorectal Cancer (HT-29) Cell Line

Magnetic iron oxide nanoparticles are among the most useful metal nanoparticles in biomedical applications. A previous study had confirmed that phytic acid-chitosan-iron oxide nanocomposite (Phy-CS-MNP) exhibited antiproliferative activity towards human colorectal cancer (HT-29) cells. Hence, in thi...

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Bibliographic Details
Main Authors: Bee Ling Tan, Mohd Esa Norhaizan, Lee Chin Chan
Format: Article
Language:English
Published: MDPI AG 2018-10-01
Series:Pharmaceutics
Subjects:
c-Jun N-terminal kinase 1
cytochrome c
cytotoxicity
inducible nitric oxide synthase
Online Access:https://www.mdpi.com/1999-4923/10/4/198

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