Specific Combinations of Inflammatory, Angiogenesis and Vascular Integrity Biomarkers Are Associated with Clinical Severity, Coma and Mortality in Beninese Children with Plasmodium Falciparum Malaria
Malaria-related deaths could be prevented if powerful diagnostic and reliable prognostic biomarkers were available to allow rapid prediction of the clinical severity allowing adequate treatment. Using quantitative ELISA, we assessed the plasma concentrations of Procalcitonin, Pentraxine-3, Ang-2, sT...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/12/2/524 |
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| author | Bernard Tornyigah Samuel Odarkwei Blankson Rafiou Adamou Azizath Moussiliou Lauriane Rietmeyer Patrick Tettey Liliane Dikroh Bernard Addo Helena Lamptey Maroufou J. Alao Annick Amoussou Caroline Padounou Christian Roussilhon Sylvie Pons Benedicta Ayiedu Mensah Nicaise Tuikue Ndam Rachida Tahar |
| author_facet | Bernard Tornyigah Samuel Odarkwei Blankson Rafiou Adamou Azizath Moussiliou Lauriane Rietmeyer Patrick Tettey Liliane Dikroh Bernard Addo Helena Lamptey Maroufou J. Alao Annick Amoussou Caroline Padounou Christian Roussilhon Sylvie Pons Benedicta Ayiedu Mensah Nicaise Tuikue Ndam Rachida Tahar |
| author_sort | Bernard Tornyigah |
| collection | DOAJ |
| description | Malaria-related deaths could be prevented if powerful diagnostic and reliable prognostic biomarkers were available to allow rapid prediction of the clinical severity allowing adequate treatment. Using quantitative ELISA, we assessed the plasma concentrations of Procalcitonin, Pentraxine-3, Ang-2, sTie-2, suPAR, sEPCR and sICAM-1 in a cohort of Beninese children with malaria to investigate their potential association with clinical manifestations of malaria. We found that all molecules showed higher levels in children with severe or cerebral malaria compared to those with uncomplicated malaria (<i>p</i>-value < 0.005). Plasma concentrations of Pentraxine-3, Procalcitonin, Ang-2 and the soluble receptors were significantly higher in children with coma as defined by a Blantyre Coma Score < 3 (<i>p</i> < 0.001 for Pentraxine-3, suPAR, and sTie-2, <i>p</i> = 0.004 for PCT, <i>p</i> = 0.005 for sICAM-1, <i>p</i> = 0.04 for Ang-2). Moreover, except for the PCT level, the concentrations of Pentraxine-3, suPAR, sEPCR, sICAM-1, sTie-2 and Ang-2 were higher among children who died from severe malaria compared to those who survived (<i>p</i> = 0.037, <i>p</i> = 0.035, <i>p</i> < 0.0001, <i>p</i>= 0.0008, <i>p</i> = 0.01 and <i>p</i> = 0.02, respectively). These findings indicate the ability of these molecules to accurately discriminate among clinical manifestations of malaria, thus, they might be potentially useful for the early prognostic of severe and fatal malaria, and to improve management of severe cases. |
| first_indexed | 2024-03-09T22:10:11Z |
| format | Article |
| id | doaj.art-32e2271cd9e44e1ca718b78c5b3e0715 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-09T22:10:11Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-32e2271cd9e44e1ca718b78c5b3e07152023-11-23T19:33:36ZengMDPI AGDiagnostics2075-44182022-02-0112252410.3390/diagnostics12020524Specific Combinations of Inflammatory, Angiogenesis and Vascular Integrity Biomarkers Are Associated with Clinical Severity, Coma and Mortality in Beninese Children with Plasmodium Falciparum MalariaBernard Tornyigah0Samuel Odarkwei Blankson1Rafiou Adamou2Azizath Moussiliou3Lauriane Rietmeyer4Patrick Tettey5Liliane Dikroh6Bernard Addo7Helena Lamptey8Maroufou J. Alao9Annick Amoussou10Caroline Padounou11Christian Roussilhon12Sylvie Pons13Benedicta Ayiedu Mensah14Nicaise Tuikue Ndam15Rachida Tahar16Université de Paris, MERIT, IRD, 75006 Paris, FranceUniversité de Paris, MERIT, IRD, 75006 Paris, FranceInstitut de Recherche Clinique du Benin (IRCB), Calavi, BeninInstitut de Recherche Clinique du Benin (IRCB), Calavi, BeninUniversité de Paris, MERIT, IRD, 75006 Paris, FranceDepartment of Immunology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Accra P.O. Box LG 581, GhanaDepartment of Immunology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Accra P.O. Box LG 581, GhanaDepartment of Immunology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Accra P.O. Box LG 581, GhanaDepartment of Immunology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Accra P.O. Box LG 581, GhanaDépartement de Pédiatrie, Hôpital Mère-Enfant la Lagune (CHUMEL), Cotonou, BeninService de Pédiatrie, Centre Hospitalo-Universitaire, Suruléré (CHU-Suruléré), Cotonou, BeninCentre Hospitalier Universitaire de l’Oueme/Plateau, Porto-Novo, BeninUnité de Génétique Fonctionnelle des Maladies Infectieuses, Département Génomes et Génétique, Institut Pasteur, 28 Rue du Docteur Roux, 75015 Paris, FranceLaboratoire Commun de Recherche Hospices Civils de Lyon-BioMérieux, Centre Hospitalier Lyon-Sud, Bâtiment 3F, 165 chemin du Grand Revoyet, 69310 Pierre-Bénite, FranceDepartment of Immunology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Accra P.O. Box LG 581, GhanaUniversité de Paris, MERIT, IRD, 75006 Paris, FranceUniversité de Paris, MERIT, IRD, 75006 Paris, FranceMalaria-related deaths could be prevented if powerful diagnostic and reliable prognostic biomarkers were available to allow rapid prediction of the clinical severity allowing adequate treatment. Using quantitative ELISA, we assessed the plasma concentrations of Procalcitonin, Pentraxine-3, Ang-2, sTie-2, suPAR, sEPCR and sICAM-1 in a cohort of Beninese children with malaria to investigate their potential association with clinical manifestations of malaria. We found that all molecules showed higher levels in children with severe or cerebral malaria compared to those with uncomplicated malaria (<i>p</i>-value < 0.005). Plasma concentrations of Pentraxine-3, Procalcitonin, Ang-2 and the soluble receptors were significantly higher in children with coma as defined by a Blantyre Coma Score < 3 (<i>p</i> < 0.001 for Pentraxine-3, suPAR, and sTie-2, <i>p</i> = 0.004 for PCT, <i>p</i> = 0.005 for sICAM-1, <i>p</i> = 0.04 for Ang-2). Moreover, except for the PCT level, the concentrations of Pentraxine-3, suPAR, sEPCR, sICAM-1, sTie-2 and Ang-2 were higher among children who died from severe malaria compared to those who survived (<i>p</i> = 0.037, <i>p</i> = 0.035, <i>p</i> < 0.0001, <i>p</i>= 0.0008, <i>p</i> = 0.01 and <i>p</i> = 0.02, respectively). These findings indicate the ability of these molecules to accurately discriminate among clinical manifestations of malaria, thus, they might be potentially useful for the early prognostic of severe and fatal malaria, and to improve management of severe cases.https://www.mdpi.com/2075-4418/12/2/524cerebral malariabiomarkerssICAM-1EPCRPTX3PCT |
| spellingShingle | Bernard Tornyigah Samuel Odarkwei Blankson Rafiou Adamou Azizath Moussiliou Lauriane Rietmeyer Patrick Tettey Liliane Dikroh Bernard Addo Helena Lamptey Maroufou J. Alao Annick Amoussou Caroline Padounou Christian Roussilhon Sylvie Pons Benedicta Ayiedu Mensah Nicaise Tuikue Ndam Rachida Tahar Specific Combinations of Inflammatory, Angiogenesis and Vascular Integrity Biomarkers Are Associated with Clinical Severity, Coma and Mortality in Beninese Children with Plasmodium Falciparum Malaria Diagnostics cerebral malaria biomarkers sICAM-1 EPCR PTX3 PCT |
| title | Specific Combinations of Inflammatory, Angiogenesis and Vascular Integrity Biomarkers Are Associated with Clinical Severity, Coma and Mortality in Beninese Children with Plasmodium Falciparum Malaria |
| title_full | Specific Combinations of Inflammatory, Angiogenesis and Vascular Integrity Biomarkers Are Associated with Clinical Severity, Coma and Mortality in Beninese Children with Plasmodium Falciparum Malaria |
| title_fullStr | Specific Combinations of Inflammatory, Angiogenesis and Vascular Integrity Biomarkers Are Associated with Clinical Severity, Coma and Mortality in Beninese Children with Plasmodium Falciparum Malaria |
| title_full_unstemmed | Specific Combinations of Inflammatory, Angiogenesis and Vascular Integrity Biomarkers Are Associated with Clinical Severity, Coma and Mortality in Beninese Children with Plasmodium Falciparum Malaria |
| title_short | Specific Combinations of Inflammatory, Angiogenesis and Vascular Integrity Biomarkers Are Associated with Clinical Severity, Coma and Mortality in Beninese Children with Plasmodium Falciparum Malaria |
| title_sort | specific combinations of inflammatory angiogenesis and vascular integrity biomarkers are associated with clinical severity coma and mortality in beninese children with plasmodium falciparum malaria |
| topic | cerebral malaria biomarkers sICAM-1 EPCR PTX3 PCT |
| url | https://www.mdpi.com/2075-4418/12/2/524 |
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