VDR promotes pancreatic cancer progression in vivo by activating CCL20-mediated M2 polarization of tumor associated macrophage

VDR promotes pancreatic cancer progression in vivo by activating CCL20-mediated M2 polarization of tumor associated macrophage

Abstract Background Activation of VDR pathway was a promising anti-tumor therapy strategy. However, numerous clinical studies have demonstrated the effect of activating VDR is limited, which indicates that VDR plays a complex role in vivos. Methods We analyzed the TCGA database to examine the associ...

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Bibliographic Details
Main Authors: Hengzhen Li, Yuli Ruan, Chao Liu, Xiaona Fan, Yuanfei Yao, Yisheng Dai, Yushuai Song, Dan Jiang, Ning Sun, Guangtao Jiao, Zhuo Chen, Shiheng Fan, Fanfei Meng, Huike Yang, Yanqiao Zhang, Zhiwei Li
Format: Article
Language:English
Published: BMC 2024-04-01
Series:Cell Communication and Signaling
Subjects:
Pancreatic adenocarcinoma
Vitamin D receptor
CCL20
Macrophage
Online Access:https://doi.org/10.1186/s12964-024-01578-x

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