Phenotypic plasticity of vascular smooth muscle cells in vascular calcification: Role of mitochondria
Vascular calcification (VC) is an important hallmark of cardiovascular disease, the osteo-/chondrocyte phenotype differentiation of vascular smooth muscle cells (VSMCs) is the main cause of vascular calcification. Accumulating evidence shows that mitochondrial dysfunction may ultimately be more detr...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2022.972836/full |
| _version_ | 1798019678556127232 |
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| author | Yan Zhong Liu Zong Xiang Li Lin Lin Zhang Dan Wang Yi Ping Liu |
| author_facet | Yan Zhong Liu Zong Xiang Li Lin Lin Zhang Dan Wang Yi Ping Liu |
| author_sort | Yan Zhong Liu |
| collection | DOAJ |
| description | Vascular calcification (VC) is an important hallmark of cardiovascular disease, the osteo-/chondrocyte phenotype differentiation of vascular smooth muscle cells (VSMCs) is the main cause of vascular calcification. Accumulating evidence shows that mitochondrial dysfunction may ultimately be more detrimental in the VSMCs calcification. Mitochondrial participate in essential cellular functions, including energy production, metabolism, redox homeostasis regulation, intracellular calcium homeostasis, apoptosis, and signal transduction. Mitochondrial dysfunction under pathological conditions results in mitochondrial reactive oxygen species (ROS) generation and metabolic disorders, which further lead to abnormal phenotypic differentiation of VSMCs. In this review, we summarize existing studies targeting mitochondria as a treatment for VC, and focus on VSMCs, highlighting recent progress in determining the roles of mitochondrial processes in regulating the phenotype transition of VSMCs, including mitochondrial biogenesis, mitochondrial dynamics, mitophagy, mitochondrial energy metabolism, and mitochondria/ER interactions. Along these lines, the impact of mitochondrial homeostasis on VC is discussed. |
| first_indexed | 2024-04-11T16:44:46Z |
| format | Article |
| id | doaj.art-32e433b2ce864a3294a1ad41048feb63 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-04-11T16:44:46Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-32e433b2ce864a3294a1ad41048feb632022-12-22T04:13:35ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2022-10-01910.3389/fcvm.2022.972836972836Phenotypic plasticity of vascular smooth muscle cells in vascular calcification: Role of mitochondriaYan Zhong LiuZong Xiang LiLin Lin ZhangDan WangYi Ping LiuVascular calcification (VC) is an important hallmark of cardiovascular disease, the osteo-/chondrocyte phenotype differentiation of vascular smooth muscle cells (VSMCs) is the main cause of vascular calcification. Accumulating evidence shows that mitochondrial dysfunction may ultimately be more detrimental in the VSMCs calcification. Mitochondrial participate in essential cellular functions, including energy production, metabolism, redox homeostasis regulation, intracellular calcium homeostasis, apoptosis, and signal transduction. Mitochondrial dysfunction under pathological conditions results in mitochondrial reactive oxygen species (ROS) generation and metabolic disorders, which further lead to abnormal phenotypic differentiation of VSMCs. In this review, we summarize existing studies targeting mitochondria as a treatment for VC, and focus on VSMCs, highlighting recent progress in determining the roles of mitochondrial processes in regulating the phenotype transition of VSMCs, including mitochondrial biogenesis, mitochondrial dynamics, mitophagy, mitochondrial energy metabolism, and mitochondria/ER interactions. Along these lines, the impact of mitochondrial homeostasis on VC is discussed.https://www.frontiersin.org/articles/10.3389/fcvm.2022.972836/fullvascular calcificationvascular smooth muscle cell (VSMC)mitochondriaphenotypic switchcardiovascular disease |
| spellingShingle | Yan Zhong Liu Zong Xiang Li Lin Lin Zhang Dan Wang Yi Ping Liu Phenotypic plasticity of vascular smooth muscle cells in vascular calcification: Role of mitochondria Frontiers in Cardiovascular Medicine vascular calcification vascular smooth muscle cell (VSMC) mitochondria phenotypic switch cardiovascular disease |
| title | Phenotypic plasticity of vascular smooth muscle cells in vascular calcification: Role of mitochondria |
| title_full | Phenotypic plasticity of vascular smooth muscle cells in vascular calcification: Role of mitochondria |
| title_fullStr | Phenotypic plasticity of vascular smooth muscle cells in vascular calcification: Role of mitochondria |
| title_full_unstemmed | Phenotypic plasticity of vascular smooth muscle cells in vascular calcification: Role of mitochondria |
| title_short | Phenotypic plasticity of vascular smooth muscle cells in vascular calcification: Role of mitochondria |
| title_sort | phenotypic plasticity of vascular smooth muscle cells in vascular calcification role of mitochondria |
| topic | vascular calcification vascular smooth muscle cell (VSMC) mitochondria phenotypic switch cardiovascular disease |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2022.972836/full |
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