Predictive Factors and Prognostic Value of Pathologic Complete Response of Internal Mammary Lymph Nodes in Breast Cancer After Neoadjuvant Chemotherapy
Objective To explore the prognostic factors of the pathological complete response of internal mammary lymph node (ipCR) after neoadjuvant chemotherapy and its effect on breast cancer prognosis. Methods We retrospectively analyzed the clinical data of 70 patients with primary breast cancer with inter...
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Magazine House of Cancer Research on Prevention and Treatment
2022-12-01
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| Series: | Zhongliu Fangzhi Yanjiu |
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| Online Access: | http://www.zlfzyj.com/EN/10.3971/j.issn.1000-8578.2022.22.0285 |
| _version_ | 1797957216977813504 |
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| author | ZHANG Weifang LIU Jinzhao ZHANG Xiangmei ZHANG Shuo MA Xiangmin LIU Yunjiang |
| author_facet | ZHANG Weifang LIU Jinzhao ZHANG Xiangmei ZHANG Shuo MA Xiangmin LIU Yunjiang |
| author_sort | ZHANG Weifang |
| collection | DOAJ |
| description | Objective To explore the prognostic factors of the pathological complete response of internal mammary lymph node (ipCR) after neoadjuvant chemotherapy and its effect on breast cancer prognosis. Methods We retrospectively analyzed the clinical data of 70 patients with primary breast cancer with internal mammary lymph node metastasis who received neoadjuvant chemotherapy. Patients were divided into the ipCR group and non-ipCR group based on their postoperative pathology. χ2 test, Fisher, and Logistic regression were used for univariate and multivariate analysis. Meanwhile, the Kaplan-Meier curve and Cox regression were used for prognostic analysis. Results Of 70 patients, 31 obtained ipCR (44.3%). Univariate analysis showed that the expression levels of apCR, HR, and HER2 status were related to ipCR (P < 0.05). Multivariate analysis showed that age, apCR, and HER2 status were independent predictors of ipCR (P < 0.05). The average DFS of ipCR group was better than non-ipCR group (96.0 vs. 67.1 months, P < 0.05). The risk of recurrence and metastasis was 87% lower in the ipCR group than in the non-ipCR group (HR=0.13, 95%CI: 0.04-0.44, P < 0.01). ipCR, Ki67 expression level, and breast pCR (bpCR) were independent factors affecting patients' prognosis. Conclusion There is a correlation between clinico pathological factors and ipCR after neoadjuvant chemotherapy. ipCR can be used to predict the prognosis of patients with internal mammary lymph node metastasis. |
| first_indexed | 2024-04-11T00:00:53Z |
| format | Article |
| id | doaj.art-32e476ec469c47b999a3c4d77a158997 |
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| issn | 1000-8578 |
| language | zho |
| last_indexed | 2024-04-11T00:00:53Z |
| publishDate | 2022-12-01 |
| publisher | Magazine House of Cancer Research on Prevention and Treatment |
| record_format | Article |
| series | Zhongliu Fangzhi Yanjiu |
| spelling | doaj.art-32e476ec469c47b999a3c4d77a1589972023-01-10T03:42:10ZzhoMagazine House of Cancer Research on Prevention and TreatmentZhongliu Fangzhi Yanjiu1000-85782022-12-0149121240124410.3971/j.issn.1000-8578.2022.22.02858578.2022.22.0285Predictive Factors and Prognostic Value of Pathologic Complete Response of Internal Mammary Lymph Nodes in Breast Cancer After Neoadjuvant ChemotherapyZHANG Weifang0LIU Jinzhao1ZHANG Xiangmei2ZHANG Shuo3MA Xiangmin4LIU Yunjiang5Breast Center, Fourth Hospital of Hebei Medical University, Shijiazhuang 050011. ChinaBreast Center, Fourth Hospital of Hebei Medical University, Shijiazhuang 050011. ChinaResearch Center, Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, ChinaBreast Center, Fourth Hospital of Hebei Medical University, Shijiazhuang 050011. ChinaDepartment of Breast Surgery, Handan Central Hospital, Handan 056001, China (*: Present: The Second Department of Thyroid and Breast Surgery, Cangzhou Central Hospital, Cangzhou 061001, China)Breast Center, Fourth Hospital of Hebei Medical University, Shijiazhuang 050011. ChinaObjective To explore the prognostic factors of the pathological complete response of internal mammary lymph node (ipCR) after neoadjuvant chemotherapy and its effect on breast cancer prognosis. Methods We retrospectively analyzed the clinical data of 70 patients with primary breast cancer with internal mammary lymph node metastasis who received neoadjuvant chemotherapy. Patients were divided into the ipCR group and non-ipCR group based on their postoperative pathology. χ2 test, Fisher, and Logistic regression were used for univariate and multivariate analysis. Meanwhile, the Kaplan-Meier curve and Cox regression were used for prognostic analysis. Results Of 70 patients, 31 obtained ipCR (44.3%). Univariate analysis showed that the expression levels of apCR, HR, and HER2 status were related to ipCR (P < 0.05). Multivariate analysis showed that age, apCR, and HER2 status were independent predictors of ipCR (P < 0.05). The average DFS of ipCR group was better than non-ipCR group (96.0 vs. 67.1 months, P < 0.05). The risk of recurrence and metastasis was 87% lower in the ipCR group than in the non-ipCR group (HR=0.13, 95%CI: 0.04-0.44, P < 0.01). ipCR, Ki67 expression level, and breast pCR (bpCR) were independent factors affecting patients' prognosis. Conclusion There is a correlation between clinico pathological factors and ipCR after neoadjuvant chemotherapy. ipCR can be used to predict the prognosis of patients with internal mammary lymph node metastasis.http://www.zlfzyj.com/EN/10.3971/j.issn.1000-8578.2022.22.0285breast cancerneoadjuvant chemotherapyinternal mammary lymph nodepathological complete response |
| spellingShingle | ZHANG Weifang LIU Jinzhao ZHANG Xiangmei ZHANG Shuo MA Xiangmin LIU Yunjiang Predictive Factors and Prognostic Value of Pathologic Complete Response of Internal Mammary Lymph Nodes in Breast Cancer After Neoadjuvant Chemotherapy Zhongliu Fangzhi Yanjiu breast cancer neoadjuvant chemotherapy internal mammary lymph node pathological complete response |
| title | Predictive Factors and Prognostic Value of Pathologic Complete Response of Internal Mammary Lymph Nodes in Breast Cancer After Neoadjuvant Chemotherapy |
| title_full | Predictive Factors and Prognostic Value of Pathologic Complete Response of Internal Mammary Lymph Nodes in Breast Cancer After Neoadjuvant Chemotherapy |
| title_fullStr | Predictive Factors and Prognostic Value of Pathologic Complete Response of Internal Mammary Lymph Nodes in Breast Cancer After Neoadjuvant Chemotherapy |
| title_full_unstemmed | Predictive Factors and Prognostic Value of Pathologic Complete Response of Internal Mammary Lymph Nodes in Breast Cancer After Neoadjuvant Chemotherapy |
| title_short | Predictive Factors and Prognostic Value of Pathologic Complete Response of Internal Mammary Lymph Nodes in Breast Cancer After Neoadjuvant Chemotherapy |
| title_sort | predictive factors and prognostic value of pathologic complete response of internal mammary lymph nodes in breast cancer after neoadjuvant chemotherapy |
| topic | breast cancer neoadjuvant chemotherapy internal mammary lymph node pathological complete response |
| url | http://www.zlfzyj.com/EN/10.3971/j.issn.1000-8578.2022.22.0285 |
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