Successful Incorporation of Exosome-Capturing Antibody-siRNA Complexes into Multiple Myeloma Cells and Suppression of Targeted mRNA Transcripts

Successful Incorporation of Exosome-Capturing Antibody-siRNA Complexes into Multiple Myeloma Cells and Suppression of Targeted mRNA Transcripts

Nucleic acid medicines have been developed as new therapeutic agents against various diseases; however, targeted delivery of these reagents into cancer cells, particularly hematologic cancer cells, via systemic administration is limited by the lack of efficient and cell-specific delivery systems. We...

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Bibliographic Details
Main Authors: Emi Soma, Asako Yamayoshi, Yuki Toda, Yuji Mishima, Shigekuni Hosogi, Eishi Ashihara
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Cancers
Subjects:
exosome
CD63
siRNA
nucleic acid medicine
drug delivery systems
antibody
Online Access:https://www.mdpi.com/2072-6694/14/3/566

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