A secreted schistosome cathepsin B1 cysteine protease and acute schistosome infection induce a transient T helper 17 response.
The natural history of schistosome infection in the mammalian host is determined by CD4+ T helper responses mounted against different parasite life cycle stages. A T helper 2 (TH2) response to schistosome eggs is required for host survival and establishment of chronic infection. However, a TH2 cell-...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2019-01-01
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| Series: | PLoS Neglected Tropical Diseases |
| Online Access: | http://europepmc.org/articles/PMC6353221?pdf=render |
| _version_ | 1811263019764678656 |
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| author | Kateryna Soloviova Ellen C Fox John P Dalton Conor R Caffrey Stephen J Davies |
| author_facet | Kateryna Soloviova Ellen C Fox John P Dalton Conor R Caffrey Stephen J Davies |
| author_sort | Kateryna Soloviova |
| collection | DOAJ |
| description | The natural history of schistosome infection in the mammalian host is determined by CD4+ T helper responses mounted against different parasite life cycle stages. A T helper 2 (TH2) response to schistosome eggs is required for host survival and establishment of chronic infection. However, a TH2 cell-derived cytokine also contributes to an immune milieu that is conducive to schistosome growth and development. Thus, the same responses that allow for host survival have been co-opted by schistosomes to facilitate parasite development and transmission, underscoring the significance of CD4+ T cell responses to both worms and eggs in the natural history of schistosome infection. Here we show that a cathepsin B1 cysteine protease secreted by schistosome worms not only induces TH2 responses, but also TH1 and TH17 responses, by a mechanism that is dependent on the proteolytic activity of the enzyme. Further investigation revealed that, in addition to the expected TH1 and TH2 responses, acute schistosome infection also induces a transient TH17 response that is rapidly down-regulated at the onset of oviposition. TH17 responses are implicated in the development of severe egg-induced pathology. The regulation of worm-induced TH17 responses during acute infection could therefore influence the expression of high and low pathology states as infection progresses. |
| first_indexed | 2024-04-12T19:37:24Z |
| format | Article |
| id | doaj.art-32e718d073934f1a871e38ea67fba021 |
| institution | Directory Open Access Journal |
| issn | 1935-2727 1935-2735 |
| language | English |
| last_indexed | 2024-04-12T19:37:24Z |
| publishDate | 2019-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Neglected Tropical Diseases |
| spelling | doaj.art-32e718d073934f1a871e38ea67fba0212022-12-22T03:19:11ZengPublic Library of Science (PLoS)PLoS Neglected Tropical Diseases1935-27271935-27352019-01-01131e000707010.1371/journal.pntd.0007070A secreted schistosome cathepsin B1 cysteine protease and acute schistosome infection induce a transient T helper 17 response.Kateryna SoloviovaEllen C FoxJohn P DaltonConor R CaffreyStephen J DaviesThe natural history of schistosome infection in the mammalian host is determined by CD4+ T helper responses mounted against different parasite life cycle stages. A T helper 2 (TH2) response to schistosome eggs is required for host survival and establishment of chronic infection. However, a TH2 cell-derived cytokine also contributes to an immune milieu that is conducive to schistosome growth and development. Thus, the same responses that allow for host survival have been co-opted by schistosomes to facilitate parasite development and transmission, underscoring the significance of CD4+ T cell responses to both worms and eggs in the natural history of schistosome infection. Here we show that a cathepsin B1 cysteine protease secreted by schistosome worms not only induces TH2 responses, but also TH1 and TH17 responses, by a mechanism that is dependent on the proteolytic activity of the enzyme. Further investigation revealed that, in addition to the expected TH1 and TH2 responses, acute schistosome infection also induces a transient TH17 response that is rapidly down-regulated at the onset of oviposition. TH17 responses are implicated in the development of severe egg-induced pathology. The regulation of worm-induced TH17 responses during acute infection could therefore influence the expression of high and low pathology states as infection progresses.http://europepmc.org/articles/PMC6353221?pdf=render |
| spellingShingle | Kateryna Soloviova Ellen C Fox John P Dalton Conor R Caffrey Stephen J Davies A secreted schistosome cathepsin B1 cysteine protease and acute schistosome infection induce a transient T helper 17 response. PLoS Neglected Tropical Diseases |
| title | A secreted schistosome cathepsin B1 cysteine protease and acute schistosome infection induce a transient T helper 17 response. |
| title_full | A secreted schistosome cathepsin B1 cysteine protease and acute schistosome infection induce a transient T helper 17 response. |
| title_fullStr | A secreted schistosome cathepsin B1 cysteine protease and acute schistosome infection induce a transient T helper 17 response. |
| title_full_unstemmed | A secreted schistosome cathepsin B1 cysteine protease and acute schistosome infection induce a transient T helper 17 response. |
| title_short | A secreted schistosome cathepsin B1 cysteine protease and acute schistosome infection induce a transient T helper 17 response. |
| title_sort | secreted schistosome cathepsin b1 cysteine protease and acute schistosome infection induce a transient t helper 17 response |
| url | http://europepmc.org/articles/PMC6353221?pdf=render |
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