Extracellular Vesicles’ Role in Angiogenesis and Altering Angiogenic Signaling
Angiogenesis, the process of new blood vessels formation from existing vasculature, plays a vital role in development, wound healing, and various pathophysiological conditions. In recent years, extracellular vesicles (EVs) have emerged as crucial mediators in intercellular communication and have gai...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-01-01
|
| Series: | Medical Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3271/12/1/4 |
| _version_ | 1797240052064976896 |
|---|---|
| author | Maryam Ateeq Mark Broadwin Frank W. Sellke M. Ruhul Abid |
| author_facet | Maryam Ateeq Mark Broadwin Frank W. Sellke M. Ruhul Abid |
| author_sort | Maryam Ateeq |
| collection | DOAJ |
| description | Angiogenesis, the process of new blood vessels formation from existing vasculature, plays a vital role in development, wound healing, and various pathophysiological conditions. In recent years, extracellular vesicles (EVs) have emerged as crucial mediators in intercellular communication and have gained significant attention for their role in modulating angiogenic processes. This review explores the multifaceted role of EVs in angiogenesis and their capacity to modulate angiogenic signaling pathways. Through comprehensive analysis of a vast body of literature, this review highlights the potential of utilizing EVs as therapeutic tools to modulate angiogenesis for both physiological and pathological purposes. A good understanding of these concepts holds promise for the development of novel therapeutic interventions targeting angiogenesis-related disorders. |
| first_indexed | 2024-04-24T18:01:18Z |
| format | Article |
| id | doaj.art-32e90266175f456c8e8135106ab5b9af |
| institution | Directory Open Access Journal |
| issn | 2076-3271 |
| language | English |
| last_indexed | 2024-04-24T18:01:18Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medical Sciences |
| spelling | doaj.art-32e90266175f456c8e8135106ab5b9af2024-03-27T13:53:56ZengMDPI AGMedical Sciences2076-32712024-01-01121410.3390/medsci12010004Extracellular Vesicles’ Role in Angiogenesis and Altering Angiogenic SignalingMaryam Ateeq0Mark Broadwin1Frank W. Sellke2M. Ruhul Abid3Division of Cardiothoracic Surgery, Department of Surgery, Cardiovascular Research Center, Rhode Island Hospital, The Warren Alpert Medical School of Brown University, Providence, RI 02903, USADivision of Cardiothoracic Surgery, Department of Surgery, Cardiovascular Research Center, Rhode Island Hospital, The Warren Alpert Medical School of Brown University, Providence, RI 02903, USADivision of Cardiothoracic Surgery, Department of Surgery, Cardiovascular Research Center, Rhode Island Hospital, The Warren Alpert Medical School of Brown University, Providence, RI 02903, USADivision of Cardiothoracic Surgery, Department of Surgery, Cardiovascular Research Center, Rhode Island Hospital, The Warren Alpert Medical School of Brown University, Providence, RI 02903, USAAngiogenesis, the process of new blood vessels formation from existing vasculature, plays a vital role in development, wound healing, and various pathophysiological conditions. In recent years, extracellular vesicles (EVs) have emerged as crucial mediators in intercellular communication and have gained significant attention for their role in modulating angiogenic processes. This review explores the multifaceted role of EVs in angiogenesis and their capacity to modulate angiogenic signaling pathways. Through comprehensive analysis of a vast body of literature, this review highlights the potential of utilizing EVs as therapeutic tools to modulate angiogenesis for both physiological and pathological purposes. A good understanding of these concepts holds promise for the development of novel therapeutic interventions targeting angiogenesis-related disorders.https://www.mdpi.com/2076-3271/12/1/4angiogenesisextracellular vesiclesangiogenic signalingexosomesmicrovesiclesapoptotic bodies |
| spellingShingle | Maryam Ateeq Mark Broadwin Frank W. Sellke M. Ruhul Abid Extracellular Vesicles’ Role in Angiogenesis and Altering Angiogenic Signaling Medical Sciences angiogenesis extracellular vesicles angiogenic signaling exosomes microvesicles apoptotic bodies |
| title | Extracellular Vesicles’ Role in Angiogenesis and Altering Angiogenic Signaling |
| title_full | Extracellular Vesicles’ Role in Angiogenesis and Altering Angiogenic Signaling |
| title_fullStr | Extracellular Vesicles’ Role in Angiogenesis and Altering Angiogenic Signaling |
| title_full_unstemmed | Extracellular Vesicles’ Role in Angiogenesis and Altering Angiogenic Signaling |
| title_short | Extracellular Vesicles’ Role in Angiogenesis and Altering Angiogenic Signaling |
| title_sort | extracellular vesicles role in angiogenesis and altering angiogenic signaling |
| topic | angiogenesis extracellular vesicles angiogenic signaling exosomes microvesicles apoptotic bodies |
| url | https://www.mdpi.com/2076-3271/12/1/4 |
| work_keys_str_mv | AT maryamateeq extracellularvesiclesroleinangiogenesisandalteringangiogenicsignaling AT markbroadwin extracellularvesiclesroleinangiogenesisandalteringangiogenicsignaling AT frankwsellke extracellularvesiclesroleinangiogenesisandalteringangiogenicsignaling AT mruhulabid extracellularvesiclesroleinangiogenesisandalteringangiogenicsignaling |