The Neutrophil Secretome as a Crucial Link between Inflammation and Thrombosis
Cardiovascular diseases are a leading cause of death. Blood–cell interactions and endothelial dysfunction are fundamental in thrombus formation, and so further knowledge of the pathways involved in such cellular crosstalk could lead to new therapeutical approaches. Neutrophils are secretory cells th...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/8/4170 |
| _version_ | 1797537306706444288 |
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| author | María Amparo Blanch-Ruiz Raquel Ortega-Luna María Ángeles Martínez-Cuesta Ángeles Álvarez |
| author_facet | María Amparo Blanch-Ruiz Raquel Ortega-Luna María Ángeles Martínez-Cuesta Ángeles Álvarez |
| author_sort | María Amparo Blanch-Ruiz |
| collection | DOAJ |
| description | Cardiovascular diseases are a leading cause of death. Blood–cell interactions and endothelial dysfunction are fundamental in thrombus formation, and so further knowledge of the pathways involved in such cellular crosstalk could lead to new therapeutical approaches. Neutrophils are secretory cells that release well-known soluble inflammatory signaling mediators and other complex cellular structures whose role is not fully understood. Studies have reported that neutrophil extracellular vesicles (EVs) and neutrophil extracellular traps (NETs) contribute to thrombosis. The objective of this review is to study the role of EVs and NETs as key factors in the transition from inflammation to thrombosis. The neutrophil secretome can promote thrombosis due to the presence of different factors in the EVs bilayer that can trigger blood clotting, and to the release of soluble mediators that induce platelet activation or aggregation. On the other hand, one of the main pathways by which NETs induce thrombosis is through the creation of a scaffold to which platelets and other blood cells adhere. In this context, platelet activation has been associated with the induction of NETs release. Hence, the structure and composition of EVs and NETs, as well as the feedback mechanism between the two processes that causes pathological thrombus formation, require exhaustive analysis to clarify their role in thrombosis. |
| first_indexed | 2024-03-10T12:13:15Z |
| format | Article |
| id | doaj.art-32e986610a2e4af488f776b3d274fa4c |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T12:13:15Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-32e986610a2e4af488f776b3d274fa4c2023-11-21T16:01:10ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-04-01228417010.3390/ijms22084170The Neutrophil Secretome as a Crucial Link between Inflammation and ThrombosisMaría Amparo Blanch-Ruiz0Raquel Ortega-Luna1María Ángeles Martínez-Cuesta2Ángeles Álvarez3Departamento de Farmacología, Facultad de Medicina, Universidad de Valencia, 46010 Valencia, SpainDepartamento de Farmacología, Facultad de Medicina, Universidad de Valencia, 46010 Valencia, SpainDepartamento de Farmacología, Facultad de Medicina, Universidad de Valencia, 46010 Valencia, SpainDepartamento de Farmacología, Facultad de Medicina, Universidad de Valencia, 46010 Valencia, SpainCardiovascular diseases are a leading cause of death. Blood–cell interactions and endothelial dysfunction are fundamental in thrombus formation, and so further knowledge of the pathways involved in such cellular crosstalk could lead to new therapeutical approaches. Neutrophils are secretory cells that release well-known soluble inflammatory signaling mediators and other complex cellular structures whose role is not fully understood. Studies have reported that neutrophil extracellular vesicles (EVs) and neutrophil extracellular traps (NETs) contribute to thrombosis. The objective of this review is to study the role of EVs and NETs as key factors in the transition from inflammation to thrombosis. The neutrophil secretome can promote thrombosis due to the presence of different factors in the EVs bilayer that can trigger blood clotting, and to the release of soluble mediators that induce platelet activation or aggregation. On the other hand, one of the main pathways by which NETs induce thrombosis is through the creation of a scaffold to which platelets and other blood cells adhere. In this context, platelet activation has been associated with the induction of NETs release. Hence, the structure and composition of EVs and NETs, as well as the feedback mechanism between the two processes that causes pathological thrombus formation, require exhaustive analysis to clarify their role in thrombosis.https://www.mdpi.com/1422-0067/22/8/4170neutrophilthrombosisinflammationsecretomeneutrophil extracellular trapsplatelets |
| spellingShingle | María Amparo Blanch-Ruiz Raquel Ortega-Luna María Ángeles Martínez-Cuesta Ángeles Álvarez The Neutrophil Secretome as a Crucial Link between Inflammation and Thrombosis International Journal of Molecular Sciences neutrophil thrombosis inflammation secretome neutrophil extracellular traps platelets |
| title | The Neutrophil Secretome as a Crucial Link between Inflammation and Thrombosis |
| title_full | The Neutrophil Secretome as a Crucial Link between Inflammation and Thrombosis |
| title_fullStr | The Neutrophil Secretome as a Crucial Link between Inflammation and Thrombosis |
| title_full_unstemmed | The Neutrophil Secretome as a Crucial Link between Inflammation and Thrombosis |
| title_short | The Neutrophil Secretome as a Crucial Link between Inflammation and Thrombosis |
| title_sort | neutrophil secretome as a crucial link between inflammation and thrombosis |
| topic | neutrophil thrombosis inflammation secretome neutrophil extracellular traps platelets |
| url | https://www.mdpi.com/1422-0067/22/8/4170 |
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