Compensatory recombination phenomena of neurological functions in central dysphagia patients
We speculate that cortical reactions evoked by swallowing activity may be abnormal in patients with central infarction with dysphagia. The present study aimed to detect functional imaging features of cerebral cortex in central dysphagia patients by using blood oxygen level-dependent functional magne...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2015-01-01
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| Series: | Neural Regeneration Research |
| Subjects: | |
| Online Access: | http://www.nrronline.org/article.asp?issn=1673-5374;year=2015;volume=10;issue=3;spage=490;epage=497;aulast=Yuan |
| _version_ | 1818428942823981056 |
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| author | Xiao-dong Yuan Li-fu Zhou Shu-juan Wang Yan-sheng Zhao Xiao-jie Wang Li-li Zhang Shou-hong Wang Ya-jie Zhang Li Chen |
| author_facet | Xiao-dong Yuan Li-fu Zhou Shu-juan Wang Yan-sheng Zhao Xiao-jie Wang Li-li Zhang Shou-hong Wang Ya-jie Zhang Li Chen |
| author_sort | Xiao-dong Yuan |
| collection | DOAJ |
| description | We speculate that cortical reactions evoked by swallowing activity may be abnormal in patients with central infarction with dysphagia. The present study aimed to detect functional imaging features of cerebral cortex in central dysphagia patients by using blood oxygen level-dependent functional magnetic resonance imaging techniques. The results showed that when normal controls swallowed, primary motor cortex (BA4), insula (BA13), premotor cortex (BA6/8), supramarginal gyrus (BA40), and anterior cingulate cortex (BA24/32) were activated, and that the size of the activated areas were larger in the left hemisphere compared with the right. In recurrent cerebral infarction patients with central dysphagia, BA4, BA13, BA40 and BA6/8 areas were activated, while the degree of activation in BA24/32 was decreased. Additionally, more areas were activated, including posterior cingulate cortex (BA23/31), visual association cortex (BA18/19), primary auditory cortex (BA41) and parahippocampal cortex (BA36). Somatosensory association cortex (BA7) and left cerebellum in patients with recurrent cerebral infarction with central dysphagia were also activated. Experimental findings suggest that the cerebral cortex has obvious hemisphere lateralization in response to swallowing, and patients with recurrent cerebral infarction with central dysphagia show compensatory recombination phenomena of neurological functions. In rehabilitative treatment, using the favorite food of patients can stimulate swallowing through visual, auditory, and other nerve conduction pathways, thus promoting compensatory recombination of the central cortex functions. |
| first_indexed | 2024-12-14T15:09:38Z |
| format | Article |
| id | doaj.art-32ec985def974650880e74112be61bba |
| institution | Directory Open Access Journal |
| issn | 1673-5374 |
| language | English |
| last_indexed | 2024-12-14T15:09:38Z |
| publishDate | 2015-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Neural Regeneration Research |
| spelling | doaj.art-32ec985def974650880e74112be61bba2022-12-21T22:56:36ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53742015-01-0110349049710.4103/1673-5374.153701Compensatory recombination phenomena of neurological functions in central dysphagia patientsXiao-dong YuanLi-fu ZhouShu-juan WangYan-sheng ZhaoXiao-jie WangLi-li ZhangShou-hong WangYa-jie ZhangLi ChenWe speculate that cortical reactions evoked by swallowing activity may be abnormal in patients with central infarction with dysphagia. The present study aimed to detect functional imaging features of cerebral cortex in central dysphagia patients by using blood oxygen level-dependent functional magnetic resonance imaging techniques. The results showed that when normal controls swallowed, primary motor cortex (BA4), insula (BA13), premotor cortex (BA6/8), supramarginal gyrus (BA40), and anterior cingulate cortex (BA24/32) were activated, and that the size of the activated areas were larger in the left hemisphere compared with the right. In recurrent cerebral infarction patients with central dysphagia, BA4, BA13, BA40 and BA6/8 areas were activated, while the degree of activation in BA24/32 was decreased. Additionally, more areas were activated, including posterior cingulate cortex (BA23/31), visual association cortex (BA18/19), primary auditory cortex (BA41) and parahippocampal cortex (BA36). Somatosensory association cortex (BA7) and left cerebellum in patients with recurrent cerebral infarction with central dysphagia were also activated. Experimental findings suggest that the cerebral cortex has obvious hemisphere lateralization in response to swallowing, and patients with recurrent cerebral infarction with central dysphagia show compensatory recombination phenomena of neurological functions. In rehabilitative treatment, using the favorite food of patients can stimulate swallowing through visual, auditory, and other nerve conduction pathways, thus promoting compensatory recombination of the central cortex functions.http://www.nrronline.org/article.asp?issn=1673-5374;year=2015;volume=10;issue=3;spage=490;epage=497;aulast=YuantamoxifenSrc kinasePP2traumaregenerationneuroprotectionauranofindextromethorphanrosiglitazoneAlzheimer′s diseaseneuroinflammationneurodegenerationmicrogliaastrocytesnerve regenerationspinal cordelectroacupuncture therapyneural stem cellsnotch signaling pathwayastrocytesinflammationsurvival curveproliferationdifferentiationreal-time quantitative PCRwestern blot assayneural regenerationnerve regenerationsuperparamagnetic iron oxidemagnetic guidancebone marrow mesenchymal stem cellsspinal cord injurycell transplantationmagnetic resonance imagelumbar punctureneural regenerationnerve regenerationspinal cord injuryspinal cord transectionaverage combined scoremagnetic resonance imagingdiffusion tensor imagingfractional anisotropyapparent diffusion coefficientfiber tractographyneural regenerationnerve regenerationperipheral nerve injurysciatic nervehypothermiablood-nerve barrierEvans blue tracerneural degenerationnerve regenerationpolyethyleneimine-polyethylene glycolspiral ganglion cellsX-linked inhibitor of apoptosis proteingene therapynanocarriercisplatinneural regenerationototoxicitycochleanerve regenerationocular hypertensionJNK3retinal ganglion cellglaucomalaser photocoagulationintraocular pressureneural regenerationnerve regenerationbrain injuryneuroprotectioninflammationapoptosiscerebral ischemiaSMAD3transforming growth factor β1NSFC grantneural regenerationneural regenerationcerebral ischemiaChinese herbal formulaTneurotrophic factorongluo Jiunao injectionnerve growth factor receptorXuesai TongneuroprotectionNSFC grantneuroprotectionneural regenerationnerve regenerationhippocampusdentate gyruslipid peroxidationtype 1 diabetesmalondialdehydeneuronsneural regenerationnerve regenerationacupuncturecerebral hemorrhageimmunohistochemistrywestern blot assayNotch1Hes1ratsDAPTneural stem cellsNSFC grantneural regenerationneural regenerationtranscranial direct current stimulationvisuomotor coordinationtask difficultyprimary motor areamotor learningneural regenerationnerve regenerationparaquatpoisoningratsendoplasmic reticulum stressapoptosisulinastatinCHOPGRP78caspase-3hippocampusreactive oxygen speciesneural regenerationnerve regenerationbrain injurycognitive neuroscienceevent-related potentialP300electrophysiologynutritional stateminimally conscious stateconsciousnessdisorders of consciousnessunconsciousnessevaluationprognosisNSFC grantsneural regenerationnerve regenerationbrain injurycurcuminischemia/reperfusion injuryoxidative stressprimary cell culturecortical neuronsoxygen-glucose deprivationpretreatmentpost-treatmentNSFC grantneural regenerationnerve regenerationblood oxygen level-dependent functional magnetic resonance imagingcerebral ischemiadysphagiafunction restructuringcerebral cortexneural regeneration |
| spellingShingle | Xiao-dong Yuan Li-fu Zhou Shu-juan Wang Yan-sheng Zhao Xiao-jie Wang Li-li Zhang Shou-hong Wang Ya-jie Zhang Li Chen Compensatory recombination phenomena of neurological functions in central dysphagia patients Neural Regeneration Research tamoxifen Src kinase PP2 trauma regeneration neuroprotection auranofin dextromethorphan rosiglitazone Alzheimer′s disease neuroinflammation neurodegeneration microglia astrocytes nerve regeneration spinal cord electroacupuncture therapy neural stem cells notch signaling pathway astrocytes inflammation survival curve proliferation differentiation real-time quantitative PCR western blot assay neural regeneration nerve regeneration superparamagnetic iron oxide magnetic guidance bone marrow mesenchymal stem cells spinal cord injury cell transplantation magnetic resonance image lumbar puncture neural regeneration nerve regeneration spinal cord injury spinal cord transection average combined score magnetic resonance imaging diffusion tensor imaging fractional anisotropy apparent diffusion coefficient fiber tractography neural regeneration nerve regeneration peripheral nerve injury sciatic nerve hypothermia blood-nerve barrier Evans blue tracer neural degeneration nerve regeneration polyethyleneimine-polyethylene glycol spiral ganglion cells X-linked inhibitor of apoptosis protein gene therapy nanocarrier cisplatin neural regeneration ototoxicity cochlea nerve regeneration ocular hypertension JNK3 retinal ganglion cell glaucoma laser photocoagulation intraocular pressure neural regeneration nerve regeneration brain injury neuroprotection inflammation apoptosis cerebral ischemia SMAD3 transforming growth factor β1 NSFC grant neural regeneration neural regeneration cerebral ischemia Chinese herbal formula Tneurotrophic factor ongluo Jiunao injection nerve growth factor receptor Xuesai Tong neuroprotection NSFC grant neuroprotection neural regeneration nerve regeneration hippocampus dentate gyrus lipid peroxidation type 1 diabetes malondialdehyde neurons neural regeneration nerve regeneration acupuncture cerebral hemorrhage immunohistochemistry western blot assay Notch1 Hes1 rats DAPT neural stem cells NSFC grant neural regeneration neural regeneration transcranial direct current stimulation visuomotor coordination task difficulty primary motor area motor learning neural regeneration nerve regeneration paraquat poisoning rats endoplasmic reticulum stress apoptosis ulinastatin CHOP GRP78 caspase-3 hippocampus reactive oxygen species neural regeneration nerve regeneration brain injury cognitive neuroscience event-related potential P300 electrophysiology nutritional state minimally conscious state consciousness disorders of consciousness unconsciousness evaluation prognosis NSFC grants neural regeneration nerve regeneration brain injury curcumin ischemia/reperfusion injury oxidative stress primary cell culture cortical neurons oxygen-glucose deprivation pretreatment post-treatment NSFC grant neural regeneration nerve regeneration blood oxygen level-dependent functional magnetic resonance imaging cerebral ischemia dysphagia function restructuring cerebral cortex neural regeneration |
| title | Compensatory recombination phenomena of neurological functions in central dysphagia patients |
| title_full | Compensatory recombination phenomena of neurological functions in central dysphagia patients |
| title_fullStr | Compensatory recombination phenomena of neurological functions in central dysphagia patients |
| title_full_unstemmed | Compensatory recombination phenomena of neurological functions in central dysphagia patients |
| title_short | Compensatory recombination phenomena of neurological functions in central dysphagia patients |
| title_sort | compensatory recombination phenomena of neurological functions in central dysphagia patients |
| topic | tamoxifen Src kinase PP2 trauma regeneration neuroprotection auranofin dextromethorphan rosiglitazone Alzheimer′s disease neuroinflammation neurodegeneration microglia astrocytes nerve regeneration spinal cord electroacupuncture therapy neural stem cells notch signaling pathway astrocytes inflammation survival curve proliferation differentiation real-time quantitative PCR western blot assay neural regeneration nerve regeneration superparamagnetic iron oxide magnetic guidance bone marrow mesenchymal stem cells spinal cord injury cell transplantation magnetic resonance image lumbar puncture neural regeneration nerve regeneration spinal cord injury spinal cord transection average combined score magnetic resonance imaging diffusion tensor imaging fractional anisotropy apparent diffusion coefficient fiber tractography neural regeneration nerve regeneration peripheral nerve injury sciatic nerve hypothermia blood-nerve barrier Evans blue tracer neural degeneration nerve regeneration polyethyleneimine-polyethylene glycol spiral ganglion cells X-linked inhibitor of apoptosis protein gene therapy nanocarrier cisplatin neural regeneration ototoxicity cochlea nerve regeneration ocular hypertension JNK3 retinal ganglion cell glaucoma laser photocoagulation intraocular pressure neural regeneration nerve regeneration brain injury neuroprotection inflammation apoptosis cerebral ischemia SMAD3 transforming growth factor β1 NSFC grant neural regeneration neural regeneration cerebral ischemia Chinese herbal formula Tneurotrophic factor ongluo Jiunao injection nerve growth factor receptor Xuesai Tong neuroprotection NSFC grant neuroprotection neural regeneration nerve regeneration hippocampus dentate gyrus lipid peroxidation type 1 diabetes malondialdehyde neurons neural regeneration nerve regeneration acupuncture cerebral hemorrhage immunohistochemistry western blot assay Notch1 Hes1 rats DAPT neural stem cells NSFC grant neural regeneration neural regeneration transcranial direct current stimulation visuomotor coordination task difficulty primary motor area motor learning neural regeneration nerve regeneration paraquat poisoning rats endoplasmic reticulum stress apoptosis ulinastatin CHOP GRP78 caspase-3 hippocampus reactive oxygen species neural regeneration nerve regeneration brain injury cognitive neuroscience event-related potential P300 electrophysiology nutritional state minimally conscious state consciousness disorders of consciousness unconsciousness evaluation prognosis NSFC grants neural regeneration nerve regeneration brain injury curcumin ischemia/reperfusion injury oxidative stress primary cell culture cortical neurons oxygen-glucose deprivation pretreatment post-treatment NSFC grant neural regeneration nerve regeneration blood oxygen level-dependent functional magnetic resonance imaging cerebral ischemia dysphagia function restructuring cerebral cortex neural regeneration |
| url | http://www.nrronline.org/article.asp?issn=1673-5374;year=2015;volume=10;issue=3;spage=490;epage=497;aulast=Yuan |
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