Is arginine supplementation effective in preventing preeclampsia in pregnant women?
Objectives: The objective of this study was to review data from randomized controlled trials to assess whether or not the supplementation of L-Arginine (L-Arg) is effective in reducing the incidence of preeclampsia (PE) in pregnancies at risk of developing the disorder. Methods: We aimed to syste...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Portuguese |
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Universidade de São Paulo
2022-05-01
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| Series: | Medicina |
| Subjects: | |
| Online Access: | https://www.revistas.usp.br/rmrp/article/view/184348 |
| _version_ | 1818541128738144256 |
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| author | Gabriel Citrangulo Ana Luísa Scafura da Fonseca Pedro Viana Diniz João Pedro Torres Neiva Rodrigues Denise Gasparetti Drumond |
| author_facet | Gabriel Citrangulo Ana Luísa Scafura da Fonseca Pedro Viana Diniz João Pedro Torres Neiva Rodrigues Denise Gasparetti Drumond |
| author_sort | Gabriel Citrangulo |
| collection | DOAJ |
| description |
Objectives: The objective of this study was to review data from randomized controlled trials to assess whether or not the supplementation of L-Arginine (L-Arg) is effective in reducing the incidence of preeclampsia (PE) in pregnancies at risk of developing the disorder.
Methods: We aimed to systematic review randomized controlled trials, including those which compared L-Arg supplementation with placebo in pregnant women at high risk of PE development, analyzing PE incidence as the main outcome. Data were collected from MEDLINE/ Pubmed, EMBASE/ Elsevier, LILACS/ BVS and Cochrane.
Results: A total of 46 papers were identified in the primary search. After analysis of eligibility, inclusion and exclusion criteria, two articles (which respected in detail all the stages of evaluation) were included in the present review. A risk of bias assessment was performed. Data analysis revealed that the incidence of PE was significantly lower in both studies, and no major adverse effects were reported. The limitations of this study were the lack of standardization between the trials analyzed and the relative low number of studies included.
Conclusions: The supplementation with L-Arg appears to reduce the incidence of PE in pregnant women with high risk for its development.
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| first_indexed | 2024-12-11T22:04:31Z |
| format | Article |
| id | doaj.art-32ef28db098e485294f9f333d0bfe626 |
| institution | Directory Open Access Journal |
| issn | 0076-6046 2176-7262 |
| language | Portuguese |
| last_indexed | 2024-12-11T22:04:31Z |
| publishDate | 2022-05-01 |
| publisher | Universidade de São Paulo |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-32ef28db098e485294f9f333d0bfe6262022-12-22T00:49:00ZporUniversidade de São PauloMedicina0076-60462176-72622022-05-01551Is arginine supplementation effective in preventing preeclampsia in pregnant women?Gabriel Citrangulo0Ana Luísa Scafura da Fonseca1Pedro Viana Diniz2João Pedro Torres Neiva Rodrigues3Denise Gasparetti Drumond4Universidade Federal de Juiz de ForaUniversidade Federal de Juiz de ForaUniversidade Federal de Juiz de ForaUniversidade Federal de Juiz de ForaUniversidade Federal de Juiz de Fora Objectives: The objective of this study was to review data from randomized controlled trials to assess whether or not the supplementation of L-Arginine (L-Arg) is effective in reducing the incidence of preeclampsia (PE) in pregnancies at risk of developing the disorder. Methods: We aimed to systematic review randomized controlled trials, including those which compared L-Arg supplementation with placebo in pregnant women at high risk of PE development, analyzing PE incidence as the main outcome. Data were collected from MEDLINE/ Pubmed, EMBASE/ Elsevier, LILACS/ BVS and Cochrane. Results: A total of 46 papers were identified in the primary search. After analysis of eligibility, inclusion and exclusion criteria, two articles (which respected in detail all the stages of evaluation) were included in the present review. A risk of bias assessment was performed. Data analysis revealed that the incidence of PE was significantly lower in both studies, and no major adverse effects were reported. The limitations of this study were the lack of standardization between the trials analyzed and the relative low number of studies included. Conclusions: The supplementation with L-Arg appears to reduce the incidence of PE in pregnant women with high risk for its development. https://www.revistas.usp.br/rmrp/article/view/184348PregnancyArgininePreeclampsiaSupplementationNitric oxide |
| spellingShingle | Gabriel Citrangulo Ana Luísa Scafura da Fonseca Pedro Viana Diniz João Pedro Torres Neiva Rodrigues Denise Gasparetti Drumond Is arginine supplementation effective in preventing preeclampsia in pregnant women? Medicina Pregnancy Arginine Preeclampsia Supplementation Nitric oxide |
| title | Is arginine supplementation effective in preventing preeclampsia in pregnant women? |
| title_full | Is arginine supplementation effective in preventing preeclampsia in pregnant women? |
| title_fullStr | Is arginine supplementation effective in preventing preeclampsia in pregnant women? |
| title_full_unstemmed | Is arginine supplementation effective in preventing preeclampsia in pregnant women? |
| title_short | Is arginine supplementation effective in preventing preeclampsia in pregnant women? |
| title_sort | is arginine supplementation effective in preventing preeclampsia in pregnant women |
| topic | Pregnancy Arginine Preeclampsia Supplementation Nitric oxide |
| url | https://www.revistas.usp.br/rmrp/article/view/184348 |
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