Self‐Aggregating Tau Fragments Recapitulate Pathologic Phenotypes and Neurotoxicity of Alzheimer's Disease in Mice

Self‐Aggregating Tau Fragments Recapitulate Pathologic Phenotypes and Neurotoxicity of Alzheimer's Disease in Mice

Abstract In tauopathy conditions, such as Alzheimer's disease (AD), highly soluble and natively unfolded tau polymerizes into an insoluble filament; however, the mechanistic details of this process remain unclear. In the brains of AD patients, only a minor segment of tau forms β‐helix‐stacked p...

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Main Authors: Ly Thi Huong Luu Le, Jeeyoung Lee, Dongjoon Im, Sunha Park, Kyoung‐Doo Hwang, Jung Hoon Lee, Yanxialei Jiang, Yong‐Seok Lee, Young Ho Suh, Hugh I. Kim, Min Jae Lee
Format: Article
Language:English
Published: Wiley 2023-10-01
Series:Advanced Science
Subjects:
aggregation
Alzheimer's disease
axon initial segment
phosphorylation
tau
Online Access:https://doi.org/10.1002/advs.202302035

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