Guanine-modified inhibitory oligonucleotides efficiently impair TLR7- and TLR9-mediated immune responses of human immune cells.
Activation of TLR7 and TLR9 by endogenous RNA- or DNA-containing ligands, respectively, is thought to contribute to the complicated pathophysiology of systemic lupus erythematosus (SLE). These ligands induce the release of type-I interferons by plasmacytoid dendritic cells and autoreactive antibodie...
| Үндсэн зохиолчид: | , , , , , , , , |
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| Формат: | Өгүүллэг |
| Хэл сонгох: | English |
| Хэвлэсэн: |
Public Library of Science (PLoS)
2015-01-01
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| Цуврал: | PLoS ONE |
| Онлайн хандалт: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0116703&type=printable |