Electrophysiological and therapeutic effects of amiodarone in patients with preexcited atrial fibrillation
Background: Atrial fibrillation (AF) with fast ventricular response over an overt accessory pathway (AP) (preexcited AF) with a short anterograde refractory period is a potentially malignant arrhythmia. This study aimed to evaluate the safety and efficacy of amiodarone for preexcited AF management....
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Journal of Research in Medical Sciences |
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| Online Access: | http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2022;volume=27;issue=1;spage=69;epage=69;aulast=Alizadeh |
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| author | Abolfath Alizadeh Maryam Pakroo Shabnam Madadi Ala Keikhavani Zahra Teimouri-Jervekani Behshid Ghadrdoost Zahra Emkanjoo |
| author_facet | Abolfath Alizadeh Maryam Pakroo Shabnam Madadi Ala Keikhavani Zahra Teimouri-Jervekani Behshid Ghadrdoost Zahra Emkanjoo |
| author_sort | Abolfath Alizadeh |
| collection | DOAJ |
| description | Background: Atrial fibrillation (AF) with fast ventricular response over an overt accessory pathway (AP) (preexcited AF) with a short anterograde refractory period is a potentially malignant arrhythmia. This study aimed to evaluate the safety and efficacy of amiodarone for preexcited AF management. Materials and Methods: This study enrolled 103 patients with evidence of AP in electrocardiography. Patients with preexcited AF were included in the study. Intravenous amiodarone (300 mg) was infused for 30 min for all patients in the AF rhythm. Electrophysiological parameters were evaluated before amiodarone injection and 2 h after pharmacological or electrical cardioversion. Results: Antegrade and retrograde refractory periods of the atrioventricular node (AVN) and AP, as well as antegrade and retrograde Wenckebach points of AVN, were increased significantly after amiodarone infusion. Furthermore, the mean of the shortest preexcited RR interval was increased during the monitoring period. Comparing the preexcited index at the beginning of the study and before cardioversion (2 h later) revealed that the QRS complexes changed to a wider pattern as the preexcitation index changed from 80.61 to 92.26 (P < 0.001). Nineteen (18.4%) patients converted to the sinus rhythm with amiodarone infusion. No ventricular arrhythmia was detected during monitoring. Conclusion: Amiodarone could be considered a safe drug in patients with preexcited AF for rate control despite its relatively low efficacy in conversion to the sinus rhythm. |
| first_indexed | 2024-04-13T19:24:20Z |
| format | Article |
| id | doaj.art-32f1dedaae09434a9048a99e5e4e7af7 |
| institution | Directory Open Access Journal |
| issn | 1735-1995 1735-7136 |
| language | English |
| last_indexed | 2024-04-13T19:24:20Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Research in Medical Sciences |
| spelling | doaj.art-32f1dedaae09434a9048a99e5e4e7af72022-12-22T02:33:24ZengWolters Kluwer Medknow PublicationsJournal of Research in Medical Sciences1735-19951735-71362022-01-01271696910.4103/jrms.jrms_91_22Electrophysiological and therapeutic effects of amiodarone in patients with preexcited atrial fibrillationAbolfath AlizadehMaryam PakrooShabnam MadadiAla KeikhavaniZahra Teimouri-JervekaniBehshid GhadrdoostZahra EmkanjooBackground: Atrial fibrillation (AF) with fast ventricular response over an overt accessory pathway (AP) (preexcited AF) with a short anterograde refractory period is a potentially malignant arrhythmia. This study aimed to evaluate the safety and efficacy of amiodarone for preexcited AF management. Materials and Methods: This study enrolled 103 patients with evidence of AP in electrocardiography. Patients with preexcited AF were included in the study. Intravenous amiodarone (300 mg) was infused for 30 min for all patients in the AF rhythm. Electrophysiological parameters were evaluated before amiodarone injection and 2 h after pharmacological or electrical cardioversion. Results: Antegrade and retrograde refractory periods of the atrioventricular node (AVN) and AP, as well as antegrade and retrograde Wenckebach points of AVN, were increased significantly after amiodarone infusion. Furthermore, the mean of the shortest preexcited RR interval was increased during the monitoring period. Comparing the preexcited index at the beginning of the study and before cardioversion (2 h later) revealed that the QRS complexes changed to a wider pattern as the preexcitation index changed from 80.61 to 92.26 (P < 0.001). Nineteen (18.4%) patients converted to the sinus rhythm with amiodarone infusion. No ventricular arrhythmia was detected during monitoring. Conclusion: Amiodarone could be considered a safe drug in patients with preexcited AF for rate control despite its relatively low efficacy in conversion to the sinus rhythm.http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2022;volume=27;issue=1;spage=69;epage=69;aulast=Alizadehaccessory pathwayamiodaroneatrial fibrillationelectrophysiology |
| spellingShingle | Abolfath Alizadeh Maryam Pakroo Shabnam Madadi Ala Keikhavani Zahra Teimouri-Jervekani Behshid Ghadrdoost Zahra Emkanjoo Electrophysiological and therapeutic effects of amiodarone in patients with preexcited atrial fibrillation Journal of Research in Medical Sciences accessory pathway amiodarone atrial fibrillation electrophysiology |
| title | Electrophysiological and therapeutic effects of amiodarone in patients with preexcited atrial fibrillation |
| title_full | Electrophysiological and therapeutic effects of amiodarone in patients with preexcited atrial fibrillation |
| title_fullStr | Electrophysiological and therapeutic effects of amiodarone in patients with preexcited atrial fibrillation |
| title_full_unstemmed | Electrophysiological and therapeutic effects of amiodarone in patients with preexcited atrial fibrillation |
| title_short | Electrophysiological and therapeutic effects of amiodarone in patients with preexcited atrial fibrillation |
| title_sort | electrophysiological and therapeutic effects of amiodarone in patients with preexcited atrial fibrillation |
| topic | accessory pathway amiodarone atrial fibrillation electrophysiology |
| url | http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2022;volume=27;issue=1;spage=69;epage=69;aulast=Alizadeh |
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