MHC-associated Baylisascaris schroederi load informs the giant panda reintroduction program
Reintroducing captive giant pandas (Ailuropoda melanoleuca) to the wild is the ultimate goal of their ex situ conservation. Choosing higher fitness candidates to train prior to release is the first step in the giant panda reintroduction program. Disease resistance is one important index of individua...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2020-08-01
|
| Series: | International Journal for Parasitology: Parasites and Wildlife |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213224420300535 |
| _version_ | 1819009166621016064 |
|---|---|
| author | Ying Zhu Catherine Grueber Yudong Li Ming He Lan Hu Ke He Hongyi Liu Hemin Zhang Honglin Wu |
| author_facet | Ying Zhu Catherine Grueber Yudong Li Ming He Lan Hu Ke He Hongyi Liu Hemin Zhang Honglin Wu |
| author_sort | Ying Zhu |
| collection | DOAJ |
| description | Reintroducing captive giant pandas (Ailuropoda melanoleuca) to the wild is the ultimate goal of their ex situ conservation. Choosing higher fitness candidates to train prior to release is the first step in the giant panda reintroduction program. Disease resistance is one important index of individual fitness and presumed to be related to variation at major histocompatibility complex genes (MHC). Here, we used seven polymorphic functional MHC genes (Aime-C, Aime-I, Aime-L, Aime-DQA1, Aime-DQA2, Aime-DQB1 and Aime-DRB3) and estimate their relationship with Baylisascaris schroederi (Ascarididae) infection in giant panda. We found that DQA1 heterozygous pandas were less frequently infected than homozygotes. The presence of one MHC genotype and one MHC allele were also associated with B. schroederi infection: Aime-C*0203 and Aime-L*08 were both associated with B. schroederi resistance. Our results indicate that both heterozygosity and certain MHC variants are important for panda disease resistance, and should therefore be considered in future reintroduction programs for this species alongside conventional selection criteria (such as physical condition and pedigree-based information). |
| first_indexed | 2024-12-21T00:52:03Z |
| format | Article |
| id | doaj.art-32f2ae24b0714e7c895460fb90d97bc8 |
| institution | Directory Open Access Journal |
| issn | 2213-2244 |
| language | English |
| last_indexed | 2024-12-21T00:52:03Z |
| publishDate | 2020-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal for Parasitology: Parasites and Wildlife |
| spelling | doaj.art-32f2ae24b0714e7c895460fb90d97bc82022-12-21T19:21:23ZengElsevierInternational Journal for Parasitology: Parasites and Wildlife2213-22442020-08-0112113120MHC-associated Baylisascaris schroederi load informs the giant panda reintroduction programYing Zhu0Catherine Grueber1Yudong Li2Ming He3Lan Hu4Ke He5Hongyi Liu6Hemin Zhang7Honglin Wu8Sichuan Province Laboratory for Natural Resources Protection and Sustainable Utilization, Sichuan Provincial Academy of Natural Resource Sciences, Chengdu, China; Faculty of Science, School of Life and Environmental Sciences, The University of Sydney, Sydney, AustraliaFaculty of Science, School of Life and Environmental Sciences, The University of Sydney, Sydney, AustraliaSichuan Province Laboratory for Natural Resources Protection and Sustainable Utilization, Sichuan Provincial Academy of Natural Resource Sciences, Chengdu, ChinaChina Conservation and Research Center for the Giant Panda, Dujiangyan, Sichuan, ChinaChina Conservation and Research Center for the Giant Panda, Dujiangyan, Sichuan, ChinaCollege of Animal Sciences & Technology, Zhejiang A & F University, Hangzhou, ChinaCollege of Biology and the Environment, Nanjing Forestry University, Nanjing, ChinaChina Conservation and Research Center for the Giant Panda, Dujiangyan, Sichuan, China; Corresponding author. China Conservation and Research Center for the Giant Panda, No. 98 Tongjiang Road, Dujiangyan, 611800, Sichuan Province, China.China Conservation and Research Center for the Giant Panda, Dujiangyan, Sichuan, China; Corresponding author. China Conservation and Research Center for the Giant Panda, No. 98 Tongjiang Road, Dujiangyan, 611800, Sichuan Province, China.Reintroducing captive giant pandas (Ailuropoda melanoleuca) to the wild is the ultimate goal of their ex situ conservation. Choosing higher fitness candidates to train prior to release is the first step in the giant panda reintroduction program. Disease resistance is one important index of individual fitness and presumed to be related to variation at major histocompatibility complex genes (MHC). Here, we used seven polymorphic functional MHC genes (Aime-C, Aime-I, Aime-L, Aime-DQA1, Aime-DQA2, Aime-DQB1 and Aime-DRB3) and estimate their relationship with Baylisascaris schroederi (Ascarididae) infection in giant panda. We found that DQA1 heterozygous pandas were less frequently infected than homozygotes. The presence of one MHC genotype and one MHC allele were also associated with B. schroederi infection: Aime-C*0203 and Aime-L*08 were both associated with B. schroederi resistance. Our results indicate that both heterozygosity and certain MHC variants are important for panda disease resistance, and should therefore be considered in future reintroduction programs for this species alongside conventional selection criteria (such as physical condition and pedigree-based information).http://www.sciencedirect.com/science/article/pii/S2213224420300535MHC typeMHC heterozygosityBaylisascaris schroederiReintroduction program |
| spellingShingle | Ying Zhu Catherine Grueber Yudong Li Ming He Lan Hu Ke He Hongyi Liu Hemin Zhang Honglin Wu MHC-associated Baylisascaris schroederi load informs the giant panda reintroduction program International Journal for Parasitology: Parasites and Wildlife MHC type MHC heterozygosity Baylisascaris schroederi Reintroduction program |
| title | MHC-associated Baylisascaris schroederi load informs the giant panda reintroduction program |
| title_full | MHC-associated Baylisascaris schroederi load informs the giant panda reintroduction program |
| title_fullStr | MHC-associated Baylisascaris schroederi load informs the giant panda reintroduction program |
| title_full_unstemmed | MHC-associated Baylisascaris schroederi load informs the giant panda reintroduction program |
| title_short | MHC-associated Baylisascaris schroederi load informs the giant panda reintroduction program |
| title_sort | mhc associated baylisascaris schroederi load informs the giant panda reintroduction program |
| topic | MHC type MHC heterozygosity Baylisascaris schroederi Reintroduction program |
| url | http://www.sciencedirect.com/science/article/pii/S2213224420300535 |
| work_keys_str_mv | AT yingzhu mhcassociatedbaylisascarisschroederiloadinformsthegiantpandareintroductionprogram AT catherinegrueber mhcassociatedbaylisascarisschroederiloadinformsthegiantpandareintroductionprogram AT yudongli mhcassociatedbaylisascarisschroederiloadinformsthegiantpandareintroductionprogram AT minghe mhcassociatedbaylisascarisschroederiloadinformsthegiantpandareintroductionprogram AT lanhu mhcassociatedbaylisascarisschroederiloadinformsthegiantpandareintroductionprogram AT kehe mhcassociatedbaylisascarisschroederiloadinformsthegiantpandareintroductionprogram AT hongyiliu mhcassociatedbaylisascarisschroederiloadinformsthegiantpandareintroductionprogram AT heminzhang mhcassociatedbaylisascarisschroederiloadinformsthegiantpandareintroductionprogram AT honglinwu mhcassociatedbaylisascarisschroederiloadinformsthegiantpandareintroductionprogram |