PIVKA-II serves as a potential biomarker that complements AFP for the diagnosis of hepatocellular carcinoma
Abstract Background Hepatocellular carcinoma (HCC) is one of the most common malignant tumors of the digestive system and has high morbidity and mortality rates. It is essential to search new biomarkers to improve the accuracy of early HCC diagnosis. Therefore, we evaluated the diagnostic value of p...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2021-04-01
|
| Series: | BMC Cancer |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12885-021-08138-3 |
| _version_ | 1819199906142748672 |
|---|---|
| author | Honglei Feng Bole Li Ze Li Qian Wei Li Ren |
| author_facet | Honglei Feng Bole Li Ze Li Qian Wei Li Ren |
| author_sort | Honglei Feng |
| collection | DOAJ |
| description | Abstract Background Hepatocellular carcinoma (HCC) is one of the most common malignant tumors of the digestive system and has high morbidity and mortality rates. It is essential to search new biomarkers to improve the accuracy of early HCC diagnosis. Therefore, we evaluated the diagnostic value of prothrombin induced by vitamin K deficiency or antagonist- II (PIVKA-II) as a potential biomarker that complements α-fetoprotein (AFP) in HCC by detecting the serum PIVKA-II levels. Methods Serum PIVKA-II levels were compared in 168 HCC patients, 150 benign liver disease patients and 153 healthy controls to investigate the PIVKA-II potential to be a HCC biomarker. Receiver operating characteristic curve (ROC) analysis was used to evaluate the value of PIVKA-II in the diagnosis of HCC and its complementary role of AFP. The correlation between serum PIVKA-II levels and clinicopathological characteristics was analyzed to study the value of PIVKA-II in assessing HCC progression and prognosis. Finally, the ability of PIVKA-II in assessing the surgical treatment effects of HCC was studied by comparing the pre- and post-operative serum PIVKA-II levels in 89 HCC patients. Results Serum PIVKA-II levels in HCC patients were significantly higher than that in patients with benign liver disease and healthy controls. The PIVKA-II performance in the diagnosing HCC as an individual biomarker was remarkable. The combined detection of PIVKA-II and AFP improved the diagnostic efficiency of HCC. PIVKA-II retained significant diagnosis capabilities for AFP-negative HCC patients. Significant correlations were found between PIVKA-II expression levels and some clinicopathological characteristics, including tumor size, tumor stage, tumor metastasis, differentiation degree and complications. PIVKA-II expression obviously decreased after surgical resection. Conclusions PIVKA-II is a promising serum biomarker for the HCC diagnosis that can be used as a supplement for AFP. The combined diagnosis of the two markers greatly improved the diagnostic efficiency of HCC. The PIVKA-II levels in HCC patients were widely associated with clinicopathological characteristics representing tumor cell dissemination and/or poor prognosis. PIVKA-II can be used to evaluate the curative effects of HCC resection. |
| first_indexed | 2024-12-23T03:23:46Z |
| format | Article |
| id | doaj.art-32f37ef720954cdbba5357872d652d71 |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-12-23T03:23:46Z |
| publishDate | 2021-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-32f37ef720954cdbba5357872d652d712022-12-21T18:01:54ZengBMCBMC Cancer1471-24072021-04-0121111010.1186/s12885-021-08138-3PIVKA-II serves as a potential biomarker that complements AFP for the diagnosis of hepatocellular carcinomaHonglei Feng0Bole Li1Ze Li2Qian Wei3Li Ren4Department of Laboratory, Tianjin Medical University Cancer Institute and Hospital, Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, National Clinical Research Center for CancerDepartment of Pharmacy, Tianjin Medical University Cancer Institute and Hospital, Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, National Clinical Research Center for CancerDepartment of Laboratory, Tianjin Medical University Cancer Institute and Hospital, Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, National Clinical Research Center for CancerDepartment of Laboratory, Tianjin Medical University Cancer Institute and Hospital, Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, National Clinical Research Center for CancerDepartment of Laboratory, Tianjin Medical University Cancer Institute and Hospital, Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, National Clinical Research Center for CancerAbstract Background Hepatocellular carcinoma (HCC) is one of the most common malignant tumors of the digestive system and has high morbidity and mortality rates. It is essential to search new biomarkers to improve the accuracy of early HCC diagnosis. Therefore, we evaluated the diagnostic value of prothrombin induced by vitamin K deficiency or antagonist- II (PIVKA-II) as a potential biomarker that complements α-fetoprotein (AFP) in HCC by detecting the serum PIVKA-II levels. Methods Serum PIVKA-II levels were compared in 168 HCC patients, 150 benign liver disease patients and 153 healthy controls to investigate the PIVKA-II potential to be a HCC biomarker. Receiver operating characteristic curve (ROC) analysis was used to evaluate the value of PIVKA-II in the diagnosis of HCC and its complementary role of AFP. The correlation between serum PIVKA-II levels and clinicopathological characteristics was analyzed to study the value of PIVKA-II in assessing HCC progression and prognosis. Finally, the ability of PIVKA-II in assessing the surgical treatment effects of HCC was studied by comparing the pre- and post-operative serum PIVKA-II levels in 89 HCC patients. Results Serum PIVKA-II levels in HCC patients were significantly higher than that in patients with benign liver disease and healthy controls. The PIVKA-II performance in the diagnosing HCC as an individual biomarker was remarkable. The combined detection of PIVKA-II and AFP improved the diagnostic efficiency of HCC. PIVKA-II retained significant diagnosis capabilities for AFP-negative HCC patients. Significant correlations were found between PIVKA-II expression levels and some clinicopathological characteristics, including tumor size, tumor stage, tumor metastasis, differentiation degree and complications. PIVKA-II expression obviously decreased after surgical resection. Conclusions PIVKA-II is a promising serum biomarker for the HCC diagnosis that can be used as a supplement for AFP. The combined diagnosis of the two markers greatly improved the diagnostic efficiency of HCC. The PIVKA-II levels in HCC patients were widely associated with clinicopathological characteristics representing tumor cell dissemination and/or poor prognosis. PIVKA-II can be used to evaluate the curative effects of HCC resection.https://doi.org/10.1186/s12885-021-08138-3Prothrombin induced by vitamin K absence or antagonist-II (PIVKA-II)Hepatocellular carcinoma (HCC)α-Fetoprotein (AFP)Diagnostic biomarkers |
| spellingShingle | Honglei Feng Bole Li Ze Li Qian Wei Li Ren PIVKA-II serves as a potential biomarker that complements AFP for the diagnosis of hepatocellular carcinoma BMC Cancer Prothrombin induced by vitamin K absence or antagonist-II (PIVKA-II) Hepatocellular carcinoma (HCC) α-Fetoprotein (AFP) Diagnostic biomarkers |
| title | PIVKA-II serves as a potential biomarker that complements AFP for the diagnosis of hepatocellular carcinoma |
| title_full | PIVKA-II serves as a potential biomarker that complements AFP for the diagnosis of hepatocellular carcinoma |
| title_fullStr | PIVKA-II serves as a potential biomarker that complements AFP for the diagnosis of hepatocellular carcinoma |
| title_full_unstemmed | PIVKA-II serves as a potential biomarker that complements AFP for the diagnosis of hepatocellular carcinoma |
| title_short | PIVKA-II serves as a potential biomarker that complements AFP for the diagnosis of hepatocellular carcinoma |
| title_sort | pivka ii serves as a potential biomarker that complements afp for the diagnosis of hepatocellular carcinoma |
| topic | Prothrombin induced by vitamin K absence or antagonist-II (PIVKA-II) Hepatocellular carcinoma (HCC) α-Fetoprotein (AFP) Diagnostic biomarkers |
| url | https://doi.org/10.1186/s12885-021-08138-3 |
| work_keys_str_mv | AT hongleifeng pivkaiiservesasapotentialbiomarkerthatcomplementsafpforthediagnosisofhepatocellularcarcinoma AT boleli pivkaiiservesasapotentialbiomarkerthatcomplementsafpforthediagnosisofhepatocellularcarcinoma AT zeli pivkaiiservesasapotentialbiomarkerthatcomplementsafpforthediagnosisofhepatocellularcarcinoma AT qianwei pivkaiiservesasapotentialbiomarkerthatcomplementsafpforthediagnosisofhepatocellularcarcinoma AT liren pivkaiiservesasapotentialbiomarkerthatcomplementsafpforthediagnosisofhepatocellularcarcinoma |