<ul>C</ul>linical <ul>e</ul>valuation of <ul>ma</ul>gnetic <ul>r</ul>esonance imaging in <ul>c</ul>oronary heart disease: The CE-MARC study
<p>Abstract</p> <p>Background</p> <p>Several investigations are currently available to establish the diagnosis of coronary heart disease (CHD). Of these, cardiovascular magnetic resonance (CMR) offers the greatest information from a single test, allowing the assessment...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2009-07-01
|
| Series: | Trials |
| Online Access: | http://www.trialsjournal.com/content/10/1/62 |
| _version_ | 1818779035571847168 |
|---|---|
| author | Sculpher Mark Ridgway John P Younger John F Dickinson Catherine Farrin Amanda J Brown Julia M Nixon Jane Radjenovic Aleksandra Maredia Neil Greenwood John P Ball Stephen G Plein Sven |
| author_facet | Sculpher Mark Ridgway John P Younger John F Dickinson Catherine Farrin Amanda J Brown Julia M Nixon Jane Radjenovic Aleksandra Maredia Neil Greenwood John P Ball Stephen G Plein Sven |
| author_sort | Sculpher Mark |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Several investigations are currently available to establish the diagnosis of coronary heart disease (CHD). Of these, cardiovascular magnetic resonance (CMR) offers the greatest information from a single test, allowing the assessment of myocardial function, perfusion, viability and coronary artery anatomy. However, data from large scale studies that prospectively evaluate the diagnostic accuracy of multi-parametric CMR for the detection of CHD in unselected populations are lacking, and there are few data on the performance of CMR compared with current diagnostic tests, its prognostic value and cost-effectiveness.</p> <p>Methods/design</p> <p>This is a prospective diagnostic accuracy cohort study of 750 patients referred to a cardiologist with suspected CHD. Exercise tolerance testing (ETT) will be preformed if patients are physically able. Recruited patients will then undergo CMR and single photon emission tomography (SPECT) followed in all patients by invasive X-ray coronary angiography. The order of the CMR and SPECT tests will be randomised. The CMR study will comprise rest and adenosine stress perfusion, cine imaging, late gadolinium enhancement and whole-heart MR coronary angiography. SPECT will use a gated stress/rest protocol. The primary objective of the study is to determine the diagnostic accuracy of CMR in detecting significant coronary stenosis, as defined by X-ray coronary angiography. Secondary objectives include an assessment of the prognostic value of CMR imaging, a comparison of its diagnostic accuracy against SPECT and ETT, and an assessment of cost-effectiveness.</p> <p>Discussion</p> <p>The CE-MARC study is a prospective, diagnostic accuracy cohort study of 750 patients assessing the performance of a multi-parametric CMR study in detecting CHD using invasive X-ray coronary angiography as the reference standard and comparing it with ETT and SPECT.</p> <p>Trial Registration</p> <p>Current Controlled Trials ISRCTN77246133</p> |
| first_indexed | 2024-12-18T11:54:13Z |
| format | Article |
| id | doaj.art-32f4ee3a84f74b3c9131fe77bd864a87 |
| institution | Directory Open Access Journal |
| issn | 1745-6215 |
| language | English |
| last_indexed | 2024-12-18T11:54:13Z |
| publishDate | 2009-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Trials |
| spelling | doaj.art-32f4ee3a84f74b3c9131fe77bd864a872022-12-21T21:09:06ZengBMCTrials1745-62152009-07-011016210.1186/1745-6215-10-62<ul>C</ul>linical <ul>e</ul>valuation of <ul>ma</ul>gnetic <ul>r</ul>esonance imaging in <ul>c</ul>oronary heart disease: The CE-MARC studySculpher MarkRidgway John PYounger John FDickinson CatherineFarrin Amanda JBrown Julia MNixon JaneRadjenovic AleksandraMaredia NeilGreenwood John PBall Stephen GPlein Sven<p>Abstract</p> <p>Background</p> <p>Several investigations are currently available to establish the diagnosis of coronary heart disease (CHD). Of these, cardiovascular magnetic resonance (CMR) offers the greatest information from a single test, allowing the assessment of myocardial function, perfusion, viability and coronary artery anatomy. However, data from large scale studies that prospectively evaluate the diagnostic accuracy of multi-parametric CMR for the detection of CHD in unselected populations are lacking, and there are few data on the performance of CMR compared with current diagnostic tests, its prognostic value and cost-effectiveness.</p> <p>Methods/design</p> <p>This is a prospective diagnostic accuracy cohort study of 750 patients referred to a cardiologist with suspected CHD. Exercise tolerance testing (ETT) will be preformed if patients are physically able. Recruited patients will then undergo CMR and single photon emission tomography (SPECT) followed in all patients by invasive X-ray coronary angiography. The order of the CMR and SPECT tests will be randomised. The CMR study will comprise rest and adenosine stress perfusion, cine imaging, late gadolinium enhancement and whole-heart MR coronary angiography. SPECT will use a gated stress/rest protocol. The primary objective of the study is to determine the diagnostic accuracy of CMR in detecting significant coronary stenosis, as defined by X-ray coronary angiography. Secondary objectives include an assessment of the prognostic value of CMR imaging, a comparison of its diagnostic accuracy against SPECT and ETT, and an assessment of cost-effectiveness.</p> <p>Discussion</p> <p>The CE-MARC study is a prospective, diagnostic accuracy cohort study of 750 patients assessing the performance of a multi-parametric CMR study in detecting CHD using invasive X-ray coronary angiography as the reference standard and comparing it with ETT and SPECT.</p> <p>Trial Registration</p> <p>Current Controlled Trials ISRCTN77246133</p>http://www.trialsjournal.com/content/10/1/62 |
| spellingShingle | Sculpher Mark Ridgway John P Younger John F Dickinson Catherine Farrin Amanda J Brown Julia M Nixon Jane Radjenovic Aleksandra Maredia Neil Greenwood John P Ball Stephen G Plein Sven <ul>C</ul>linical <ul>e</ul>valuation of <ul>ma</ul>gnetic <ul>r</ul>esonance imaging in <ul>c</ul>oronary heart disease: The CE-MARC study Trials |
| title | <ul>C</ul>linical <ul>e</ul>valuation of <ul>ma</ul>gnetic <ul>r</ul>esonance imaging in <ul>c</ul>oronary heart disease: The CE-MARC study |
| title_full | <ul>C</ul>linical <ul>e</ul>valuation of <ul>ma</ul>gnetic <ul>r</ul>esonance imaging in <ul>c</ul>oronary heart disease: The CE-MARC study |
| title_fullStr | <ul>C</ul>linical <ul>e</ul>valuation of <ul>ma</ul>gnetic <ul>r</ul>esonance imaging in <ul>c</ul>oronary heart disease: The CE-MARC study |
| title_full_unstemmed | <ul>C</ul>linical <ul>e</ul>valuation of <ul>ma</ul>gnetic <ul>r</ul>esonance imaging in <ul>c</ul>oronary heart disease: The CE-MARC study |
| title_short | <ul>C</ul>linical <ul>e</ul>valuation of <ul>ma</ul>gnetic <ul>r</ul>esonance imaging in <ul>c</ul>oronary heart disease: The CE-MARC study |
| title_sort | ul c ul linical ul e ul valuation of ul ma ul gnetic ul r ul esonance imaging in ul c ul oronary heart disease the ce marc study |
| url | http://www.trialsjournal.com/content/10/1/62 |
| work_keys_str_mv | AT sculphermark ulcullinicaluleulvaluationofulmaulgneticulrulesonanceimaginginulculoronaryheartdiseasethecemarcstudy AT ridgwayjohnp ulcullinicaluleulvaluationofulmaulgneticulrulesonanceimaginginulculoronaryheartdiseasethecemarcstudy AT youngerjohnf ulcullinicaluleulvaluationofulmaulgneticulrulesonanceimaginginulculoronaryheartdiseasethecemarcstudy AT dickinsoncatherine ulcullinicaluleulvaluationofulmaulgneticulrulesonanceimaginginulculoronaryheartdiseasethecemarcstudy AT farrinamandaj ulcullinicaluleulvaluationofulmaulgneticulrulesonanceimaginginulculoronaryheartdiseasethecemarcstudy AT brownjuliam ulcullinicaluleulvaluationofulmaulgneticulrulesonanceimaginginulculoronaryheartdiseasethecemarcstudy AT nixonjane ulcullinicaluleulvaluationofulmaulgneticulrulesonanceimaginginulculoronaryheartdiseasethecemarcstudy AT radjenovicaleksandra ulcullinicaluleulvaluationofulmaulgneticulrulesonanceimaginginulculoronaryheartdiseasethecemarcstudy AT maredianeil ulcullinicaluleulvaluationofulmaulgneticulrulesonanceimaginginulculoronaryheartdiseasethecemarcstudy AT greenwoodjohnp ulcullinicaluleulvaluationofulmaulgneticulrulesonanceimaginginulculoronaryheartdiseasethecemarcstudy AT ballstepheng ulcullinicaluleulvaluationofulmaulgneticulrulesonanceimaginginulculoronaryheartdiseasethecemarcstudy AT pleinsven ulcullinicaluleulvaluationofulmaulgneticulrulesonanceimaginginulculoronaryheartdiseasethecemarcstudy |