<i>Tremella fuciformis</i> Crude Polysaccharides Attenuates Steatosis and Suppresses Inflammation in Diet-Induced NAFLD Mice
Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disorder characterized by an enhanced accumulation of lipids, which affects around 40% of the world’s population. The <i>T. fuciformis</i> fungus possesses immunomodulatory activity and other beneficial properties that may allev...
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2022-03-01
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author | Tariq Jamal Khan Xiaofei Xu Xiaoling Xie Ximing Dai Pingnan Sun Qingdong Xie Xiaoling Zhou |
author_facet | Tariq Jamal Khan Xiaofei Xu Xiaoling Xie Ximing Dai Pingnan Sun Qingdong Xie Xiaoling Zhou |
author_sort | Tariq Jamal Khan |
collection | DOAJ |
description | Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disorder characterized by an enhanced accumulation of lipids, which affects around 40% of the world’s population. The <i>T. fuciformis</i> fungus possesses immunomodulatory activity and other beneficial properties that may alleviate steatosis through a different mechanism. The present study was designed to evaluate the effect <i>T. fuciformis</i> crude polysaccharides (TFCP) on inflammatory and lipid metabolism gene expression, oxidative stress, and lipid profile. Mice were divided into groups receiving (a) a normal chow diet (NCD), (b) a methionine–choline-deficient (MCD) diet, and (c) a MCD diet with TFCP. Liver histopathology was performed, and the hepatic gene expression levels were estimated using qRT-PCR. The lipid profiles, ALT, AST, and efficient oxidative enzymes were analyzed using ELISA. The TFCP administration in the MCD-fed mice suppressed hepatic lipid accumulation, lipid metabolism-associated genes (HMGCR, FABP, SREBP, ACC, and FAS), and inflammation-associated genes (IL-1β, TLR4, TNF-α, and IL-6) whilst enhancing the expression of HNF4α genes. TFCP mitigated against oxidative stress and normalized healthy lipid profiles. These results highlighted that TFCP prevents NAFLD through the inhibition of oxidative stress and inflammation, suggesting TFCP would potentially be an effective therapeutic agent against NAFLD progression. |
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series | Current Issues in Molecular Biology |
spelling | doaj.art-32f53a615e3a4d62b76d7dd90769b61f2023-11-24T00:48:25ZengMDPI AGCurrent Issues in Molecular Biology1467-30371467-30452022-03-014431224123410.3390/cimb44030081<i>Tremella fuciformis</i> Crude Polysaccharides Attenuates Steatosis and Suppresses Inflammation in Diet-Induced NAFLD MiceTariq Jamal Khan0Xiaofei Xu1Xiaoling Xie2Ximing Dai3Pingnan Sun4Qingdong Xie5Xiaoling Zhou6Guangdong Provincial Key Laboratory of Infectious Diseases and Molecular Immunopathology, Shantou University Medical College, Shantou 515041, ChinaGeometry Cell Biology Research Center, Dongguan 523808, ChinaGuangdong Provincial Key Laboratory of Infectious Diseases and Molecular Immunopathology, Shantou University Medical College, Shantou 515041, ChinaGuangdong Provincial Key Laboratory of Infectious Diseases and Molecular Immunopathology, Shantou University Medical College, Shantou 515041, ChinaGuangdong Provincial Key Laboratory of Infectious Diseases and Molecular Immunopathology, Shantou University Medical College, Shantou 515041, ChinaGuangdong Provincial Key Laboratory of Infectious Diseases and Molecular Immunopathology, Shantou University Medical College, Shantou 515041, ChinaGuangdong Provincial Key Laboratory of Infectious Diseases and Molecular Immunopathology, Shantou University Medical College, Shantou 515041, ChinaNonalcoholic fatty liver disease (NAFLD) is a chronic liver disorder characterized by an enhanced accumulation of lipids, which affects around 40% of the world’s population. The <i>T. fuciformis</i> fungus possesses immunomodulatory activity and other beneficial properties that may alleviate steatosis through a different mechanism. The present study was designed to evaluate the effect <i>T. fuciformis</i> crude polysaccharides (TFCP) on inflammatory and lipid metabolism gene expression, oxidative stress, and lipid profile. Mice were divided into groups receiving (a) a normal chow diet (NCD), (b) a methionine–choline-deficient (MCD) diet, and (c) a MCD diet with TFCP. Liver histopathology was performed, and the hepatic gene expression levels were estimated using qRT-PCR. The lipid profiles, ALT, AST, and efficient oxidative enzymes were analyzed using ELISA. The TFCP administration in the MCD-fed mice suppressed hepatic lipid accumulation, lipid metabolism-associated genes (HMGCR, FABP, SREBP, ACC, and FAS), and inflammation-associated genes (IL-1β, TLR4, TNF-α, and IL-6) whilst enhancing the expression of HNF4α genes. TFCP mitigated against oxidative stress and normalized healthy lipid profiles. These results highlighted that TFCP prevents NAFLD through the inhibition of oxidative stress and inflammation, suggesting TFCP would potentially be an effective therapeutic agent against NAFLD progression.https://www.mdpi.com/1467-3045/44/3/81<i>Tremella fuciformis</i> crude polysaccharidesnonalcoholic fatty liver diseasemethionine–choline-deficient diet |
spellingShingle | Tariq Jamal Khan Xiaofei Xu Xiaoling Xie Ximing Dai Pingnan Sun Qingdong Xie Xiaoling Zhou <i>Tremella fuciformis</i> Crude Polysaccharides Attenuates Steatosis and Suppresses Inflammation in Diet-Induced NAFLD Mice Current Issues in Molecular Biology <i>Tremella fuciformis</i> crude polysaccharides nonalcoholic fatty liver disease methionine–choline-deficient diet |
title | <i>Tremella fuciformis</i> Crude Polysaccharides Attenuates Steatosis and Suppresses Inflammation in Diet-Induced NAFLD Mice |
title_full | <i>Tremella fuciformis</i> Crude Polysaccharides Attenuates Steatosis and Suppresses Inflammation in Diet-Induced NAFLD Mice |
title_fullStr | <i>Tremella fuciformis</i> Crude Polysaccharides Attenuates Steatosis and Suppresses Inflammation in Diet-Induced NAFLD Mice |
title_full_unstemmed | <i>Tremella fuciformis</i> Crude Polysaccharides Attenuates Steatosis and Suppresses Inflammation in Diet-Induced NAFLD Mice |
title_short | <i>Tremella fuciformis</i> Crude Polysaccharides Attenuates Steatosis and Suppresses Inflammation in Diet-Induced NAFLD Mice |
title_sort | i tremella fuciformis i crude polysaccharides attenuates steatosis and suppresses inflammation in diet induced nafld mice |
topic | <i>Tremella fuciformis</i> crude polysaccharides nonalcoholic fatty liver disease methionine–choline-deficient diet |
url | https://www.mdpi.com/1467-3045/44/3/81 |
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