Th2 to Th1 Transition Is Required for Induction of Skin Lesions in an Inducible and Recurrent Murine Model of Cutaneous Lupus–Like Inflammation

Th2 to Th1 Transition Is Required for Induction of Skin Lesions in an Inducible and Recurrent Murine Model of Cutaneous Lupus–Like Inflammation

Cutaneous lupus erythematosus (CLE) is an autoimmune skin disease characterized by a strong IFN signature, normally associated with type I IFNs. However, increasing evidence points to an additional role for IFNγ, or at least a pathogenic T effector subset dependent on IFNγ, for disease progression....

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Bibliographic Details
Main Authors: Nazgol-Sadat Haddadi, Purvi Mande, Tia Y. Brodeur, Kaiyuan Hao, Grace E. Ryan, Stephanie Moses, Sharon Subramanian, Xhuliana Picari, Khashayar Afshari, Ann Marshak-Rothstein, Jillian M. Richmond
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Immunology
Subjects:
cutaneous lupus erythematosus
CD4+ helper T cell
Lupus flare
CXCR6
Th1 & Th2
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.883375/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.883375/full

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