Procollagen C-proteinase enhancer-1 (PCPE-1), a potential biomarker and therapeutic target for fibrosis
The correct balance between collagen synthesis and degradation is essential for almost every aspect of life, from development to healthy aging, reproduction and wound healing. When this balance is compromised by external or internal stress signals, it very often leads to disease as is the case in fi...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-08-01
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| Series: | Matrix Biology Plus |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590028521000065 |
| _version_ | 1818725708040503296 |
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| author | Priscillia Lagoutte Emmanuel Bettler Sandrine Vadon-Le Goff Catherine Moali |
| author_facet | Priscillia Lagoutte Emmanuel Bettler Sandrine Vadon-Le Goff Catherine Moali |
| author_sort | Priscillia Lagoutte |
| collection | DOAJ |
| description | The correct balance between collagen synthesis and degradation is essential for almost every aspect of life, from development to healthy aging, reproduction and wound healing. When this balance is compromised by external or internal stress signals, it very often leads to disease as is the case in fibrotic conditions. Fibrosis occurs in the context of defective tissue repair and is characterized by the excessive, aberrant and debilitating deposition of fibril-forming collagens. Therefore, the numerous proteins involved in the biosynthesis of fibrillar collagens represent a potential and still underexploited source of therapeutic targets to prevent fibrosis. One such target is procollagen C-proteinase enhancer-1 (PCPE-1) which has the unique ability to accelerate procollagen maturation by BMP-1/tolloid-like proteinases (BTPs) and contributes to trigger collagen fibrillogenesis, without interfering with other BTP functions or the activities of other extracellular metalloproteinases. This role is achieved through a fine-tuned mechanism of action that is close to being elucidated and offers promising perspectives for drug design. Finally, the in vivo data accumulated in recent years also confirm that PCPE-1 overexpression is a general feature and early marker of fibrosis. In this review, we describe the results which presently support the driving role of PCPE-1 in fibrosis and discuss the questions that remain to be solved to validate its use as a biomarker or therapeutic target. |
| first_indexed | 2024-12-17T21:46:36Z |
| format | Article |
| id | doaj.art-32f89c3c3aaf4573bedc6cde1f055dd7 |
| institution | Directory Open Access Journal |
| issn | 2590-0285 |
| language | English |
| last_indexed | 2024-12-17T21:46:36Z |
| publishDate | 2021-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Matrix Biology Plus |
| spelling | doaj.art-32f89c3c3aaf4573bedc6cde1f055dd72022-12-21T21:31:26ZengElsevierMatrix Biology Plus2590-02852021-08-0111100062Procollagen C-proteinase enhancer-1 (PCPE-1), a potential biomarker and therapeutic target for fibrosisPriscillia Lagoutte0Emmanuel Bettler1Sandrine Vadon-Le Goff2Catherine Moali3University of Lyon, CNRS, Tissue Biology and Therapeutic Engineering Laboratory, LBTI, UMR5305, F-69367 Lyon, FranceUniversity of Lyon, CNRS, Tissue Biology and Therapeutic Engineering Laboratory, LBTI, UMR5305, F-69367 Lyon, FranceUniversity of Lyon, CNRS, Tissue Biology and Therapeutic Engineering Laboratory, LBTI, UMR5305, F-69367 Lyon, FranceCorresponding author at: Tissue Biology and Therapeutic Engineering Laboratory – LBTI, 7, Passage du Vercors, 69367 Lyon Cedex 07, France.; University of Lyon, CNRS, Tissue Biology and Therapeutic Engineering Laboratory, LBTI, UMR5305, F-69367 Lyon, FranceThe correct balance between collagen synthesis and degradation is essential for almost every aspect of life, from development to healthy aging, reproduction and wound healing. When this balance is compromised by external or internal stress signals, it very often leads to disease as is the case in fibrotic conditions. Fibrosis occurs in the context of defective tissue repair and is characterized by the excessive, aberrant and debilitating deposition of fibril-forming collagens. Therefore, the numerous proteins involved in the biosynthesis of fibrillar collagens represent a potential and still underexploited source of therapeutic targets to prevent fibrosis. One such target is procollagen C-proteinase enhancer-1 (PCPE-1) which has the unique ability to accelerate procollagen maturation by BMP-1/tolloid-like proteinases (BTPs) and contributes to trigger collagen fibrillogenesis, without interfering with other BTP functions or the activities of other extracellular metalloproteinases. This role is achieved through a fine-tuned mechanism of action that is close to being elucidated and offers promising perspectives for drug design. Finally, the in vivo data accumulated in recent years also confirm that PCPE-1 overexpression is a general feature and early marker of fibrosis. In this review, we describe the results which presently support the driving role of PCPE-1 in fibrosis and discuss the questions that remain to be solved to validate its use as a biomarker or therapeutic target.http://www.sciencedirect.com/science/article/pii/S2590028521000065FibrosisCollagenFibrillogenesisProteolysisTherapeutic targetBiomarker |
| spellingShingle | Priscillia Lagoutte Emmanuel Bettler Sandrine Vadon-Le Goff Catherine Moali Procollagen C-proteinase enhancer-1 (PCPE-1), a potential biomarker and therapeutic target for fibrosis Matrix Biology Plus Fibrosis Collagen Fibrillogenesis Proteolysis Therapeutic target Biomarker |
| title | Procollagen C-proteinase enhancer-1 (PCPE-1), a potential biomarker and therapeutic target for fibrosis |
| title_full | Procollagen C-proteinase enhancer-1 (PCPE-1), a potential biomarker and therapeutic target for fibrosis |
| title_fullStr | Procollagen C-proteinase enhancer-1 (PCPE-1), a potential biomarker and therapeutic target for fibrosis |
| title_full_unstemmed | Procollagen C-proteinase enhancer-1 (PCPE-1), a potential biomarker and therapeutic target for fibrosis |
| title_short | Procollagen C-proteinase enhancer-1 (PCPE-1), a potential biomarker and therapeutic target for fibrosis |
| title_sort | procollagen c proteinase enhancer 1 pcpe 1 a potential biomarker and therapeutic target for fibrosis |
| topic | Fibrosis Collagen Fibrillogenesis Proteolysis Therapeutic target Biomarker |
| url | http://www.sciencedirect.com/science/article/pii/S2590028521000065 |
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