Treatment outcomes of unknown primary squamous cell carcinoma of the head and neck.
BACKGROUND:Treatment modality of unknown primary squamous cell carcinoma of the head and neck (SCCHN) remains controversial. OBJECTIVES:To evaluate the treatment outcomes and prognostic factors of unknown primary SCCHN. MATERIALS AND METHODS:Patients with unknown primary SCCHN from April 1995 to Mar...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2018-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC6193660?pdf=render |
| _version_ | 1819059445077901312 |
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| author | Yu-Hsuan Hung Shih-An Liu Chen-Chi Wang Ching-Ping Wang Rong-San Jiang Shang-Heng Wu |
| author_facet | Yu-Hsuan Hung Shih-An Liu Chen-Chi Wang Ching-Ping Wang Rong-San Jiang Shang-Heng Wu |
| author_sort | Yu-Hsuan Hung |
| collection | DOAJ |
| description | BACKGROUND:Treatment modality of unknown primary squamous cell carcinoma of the head and neck (SCCHN) remains controversial. OBJECTIVES:To evaluate the treatment outcomes and prognostic factors of unknown primary SCCHN. MATERIALS AND METHODS:Patients with unknown primary SCCHN from April 1995 to March 2013 were recruited retrospectively. RESULTS:Sixty-nine patients were enrolled. The median time of follow-up was 55.5 months. The 2-year loco-regional control rate of all the patients was 60.4%. Multivariate Cox regression analysis revealed that N3 stage, extracapsular spread, distant metastasis, and treatment modality were significantly associated with neck recurrence. The actuarial 5-year disease-specific survival rates of neck dissection, neck dissection plus adjuvant therapy, radiotherapy alone, and combined therapy were 80.0%, 61.7%, 33.3%, and 68.8%, respectively (p = 0.046). The 5-year disease-specific survival rates of N1/N2a, N2b/N2c, and N3 stage were 83.9%, 64.3%, and 36.7%, respectively (p = 0.013). Univariate regression analysis revealed that neck recurrence, supraclavicular node involvement, distant metastasis, N3 stage, and unhealthy lifestyle habits were correlated with disease-specific mortality, especially the first three parameters. Patient's occupation and comorbidity were not significantly correlated with survival. CONCLUSIONS:Composite therapy is mandatory for advanced unknown primary SCCHN. Supraclavicular node involvement and unhealthy lifestyle habits, such as betel nut chewing, indicate a poor prognosis. |
| first_indexed | 2024-12-21T14:11:12Z |
| format | Article |
| id | doaj.art-32fd0315827c400dac0ca5df1ccbb1cb |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T14:11:12Z |
| publishDate | 2018-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-32fd0315827c400dac0ca5df1ccbb1cb2022-12-21T19:01:02ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-011310e020536510.1371/journal.pone.0205365Treatment outcomes of unknown primary squamous cell carcinoma of the head and neck.Yu-Hsuan HungShih-An LiuChen-Chi WangChing-Ping WangRong-San JiangShang-Heng WuBACKGROUND:Treatment modality of unknown primary squamous cell carcinoma of the head and neck (SCCHN) remains controversial. OBJECTIVES:To evaluate the treatment outcomes and prognostic factors of unknown primary SCCHN. MATERIALS AND METHODS:Patients with unknown primary SCCHN from April 1995 to March 2013 were recruited retrospectively. RESULTS:Sixty-nine patients were enrolled. The median time of follow-up was 55.5 months. The 2-year loco-regional control rate of all the patients was 60.4%. Multivariate Cox regression analysis revealed that N3 stage, extracapsular spread, distant metastasis, and treatment modality were significantly associated with neck recurrence. The actuarial 5-year disease-specific survival rates of neck dissection, neck dissection plus adjuvant therapy, radiotherapy alone, and combined therapy were 80.0%, 61.7%, 33.3%, and 68.8%, respectively (p = 0.046). The 5-year disease-specific survival rates of N1/N2a, N2b/N2c, and N3 stage were 83.9%, 64.3%, and 36.7%, respectively (p = 0.013). Univariate regression analysis revealed that neck recurrence, supraclavicular node involvement, distant metastasis, N3 stage, and unhealthy lifestyle habits were correlated with disease-specific mortality, especially the first three parameters. Patient's occupation and comorbidity were not significantly correlated with survival. CONCLUSIONS:Composite therapy is mandatory for advanced unknown primary SCCHN. Supraclavicular node involvement and unhealthy lifestyle habits, such as betel nut chewing, indicate a poor prognosis.http://europepmc.org/articles/PMC6193660?pdf=render |
| spellingShingle | Yu-Hsuan Hung Shih-An Liu Chen-Chi Wang Ching-Ping Wang Rong-San Jiang Shang-Heng Wu Treatment outcomes of unknown primary squamous cell carcinoma of the head and neck. PLoS ONE |
| title | Treatment outcomes of unknown primary squamous cell carcinoma of the head and neck. |
| title_full | Treatment outcomes of unknown primary squamous cell carcinoma of the head and neck. |
| title_fullStr | Treatment outcomes of unknown primary squamous cell carcinoma of the head and neck. |
| title_full_unstemmed | Treatment outcomes of unknown primary squamous cell carcinoma of the head and neck. |
| title_short | Treatment outcomes of unknown primary squamous cell carcinoma of the head and neck. |
| title_sort | treatment outcomes of unknown primary squamous cell carcinoma of the head and neck |
| url | http://europepmc.org/articles/PMC6193660?pdf=render |
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