Molecular and Genetic Basics and Strategy of Bronchial Asthma Analysis in Children
The phenotype features of bronchial asthma (BA) in 94 children from the Ivano-Frankivsk region with different types of the allelic polymorphism of microsomal epoxide hydrolase gene 1 (mEPXH 1) have been studied. The association between the polymorphism of mEPXH 1 gene and predisposition to appearanc...
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| Format: | Article |
| Language: | English |
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Zaslavsky O.Yu.
2012-10-01
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| Series: | Zdorovʹe Rebenka |
| Subjects: | |
| Online Access: | http://childshealth.zaslavsky.com.ua/article/view/193645 |
| _version_ | 1828143407057338368 |
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| author | L.Ya. Lytvynets O.B. Synoverska O.Z. Gnateyko N.V. Vyshtak |
| author_facet | L.Ya. Lytvynets O.B. Synoverska O.Z. Gnateyko N.V. Vyshtak |
| author_sort | L.Ya. Lytvynets |
| collection | DOAJ |
| description | The phenotype features of bronchial asthma (BA) in 94 children from the Ivano-Frankivsk region with different types of the allelic polymorphism of microsomal epoxide hydrolase gene 1 (mEPXH 1) have been studied. The association between the polymorphism of mEPXH 1 gene and predisposition to appearance and severity of asthma in children has been described. It is found that individual types of metabolic activity of xenobiotic detoxification genes influence the BA realization. It’s proved that СС and GG (p < 0.05) genotypes of BA were noticed more frequently in patients with uncontrolled bronchial asthma. High enzyme activity of mEPHX 1 gene (polymorphic AG-TT and AA-TT types) is more often observed in children with BA. Slow allele of mEPHX 1 gene responding to variants of homo- and heterozygotes by mutant alleles CC-AA and TC-AA is quite often. |
| first_indexed | 2024-04-11T19:56:43Z |
| format | Article |
| id | doaj.art-32ffc849948941d1afb03bab98959157 |
| institution | Directory Open Access Journal |
| issn | 2224-0551 2307-1168 |
| language | English |
| last_indexed | 2024-04-11T19:56:43Z |
| publishDate | 2012-10-01 |
| publisher | Zaslavsky O.Yu. |
| record_format | Article |
| series | Zdorovʹe Rebenka |
| spelling | doaj.art-32ffc849948941d1afb03bab989591572022-12-22T04:05:57ZengZaslavsky O.Yu.Zdorovʹe Rebenka2224-05512307-11682012-10-0107.42858910.22141/2224-0551.0.7.42.2012.193645193645Molecular and Genetic Basics and Strategy of Bronchial Asthma Analysis in ChildrenL.Ya. Lytvynets0O.B. Synoverska1O.Z. Gnateyko2N.V. Vyshtak3State Higher Educational Institution «Ivano-Frankivsk National Medical University»State Higher Educational Institution «Ivano-Frankivsk National Medical University»State Institution «Institute of Hereditary Disease», Lviv, UkraineState Institution «Institute of Hereditary Disease», Lviv, UkraineThe phenotype features of bronchial asthma (BA) in 94 children from the Ivano-Frankivsk region with different types of the allelic polymorphism of microsomal epoxide hydrolase gene 1 (mEPXH 1) have been studied. The association between the polymorphism of mEPXH 1 gene and predisposition to appearance and severity of asthma in children has been described. It is found that individual types of metabolic activity of xenobiotic detoxification genes influence the BA realization. It’s proved that СС and GG (p < 0.05) genotypes of BA were noticed more frequently in patients with uncontrolled bronchial asthma. High enzyme activity of mEPHX 1 gene (polymorphic AG-TT and AA-TT types) is more often observed in children with BA. Slow allele of mEPHX 1 gene responding to variants of homo- and heterozygotes by mutant alleles CC-AA and TC-AA is quite often.http://childshealth.zaslavsky.com.ua/article/view/193645bronchial asthma, children, xenobiotic detoxification genes |
| spellingShingle | L.Ya. Lytvynets O.B. Synoverska O.Z. Gnateyko N.V. Vyshtak Molecular and Genetic Basics and Strategy of Bronchial Asthma Analysis in Children Zdorovʹe Rebenka bronchial asthma, children, xenobiotic detoxification genes |
| title | Molecular and Genetic Basics and Strategy of Bronchial Asthma Analysis in Children |
| title_full | Molecular and Genetic Basics and Strategy of Bronchial Asthma Analysis in Children |
| title_fullStr | Molecular and Genetic Basics and Strategy of Bronchial Asthma Analysis in Children |
| title_full_unstemmed | Molecular and Genetic Basics and Strategy of Bronchial Asthma Analysis in Children |
| title_short | Molecular and Genetic Basics and Strategy of Bronchial Asthma Analysis in Children |
| title_sort | molecular and genetic basics and strategy of bronchial asthma analysis in children |
| topic | bronchial asthma, children, xenobiotic detoxification genes |
| url | http://childshealth.zaslavsky.com.ua/article/view/193645 |
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