Copper(ii) complexes supported by modified azo-based ligands: Nucleic acid binding and molecular docking studies
Two new copper(ii) complexes [CuL1] (1) and [CuL2] (2) derived from azo-based ligands 2-hydroxy-5-p-tolylazo-benzaldehyde (HL1) and 1-(2-hydroxy-5-p-tolylazo-phenyl)-ethan-one (HL2) were synthesized. These two ligands and their metal complexes were characterized by elemental analysis, nuclear magnet...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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De Gruyter
2022-06-01
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| Series: | Open Chemistry |
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| Online Access: | https://doi.org/10.1515/chem-2022-0164 |
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| author | Tripathi Mamta Asatkar Ashish Kumar Antony Stalin Dash Mrinal Kanti Roymahapatra Gourisankar Pande Rama Sarkar Avijit Aldakheel Fahad M. Binshaya Abdulkarim S. Alharthi Nahed S. Alaofi Ahmed L. Alqahtani Mohammed S. Syed Rabbani |
| author_facet | Tripathi Mamta Asatkar Ashish Kumar Antony Stalin Dash Mrinal Kanti Roymahapatra Gourisankar Pande Rama Sarkar Avijit Aldakheel Fahad M. Binshaya Abdulkarim S. Alharthi Nahed S. Alaofi Ahmed L. Alqahtani Mohammed S. Syed Rabbani |
| author_sort | Tripathi Mamta |
| collection | DOAJ |
| description | Two new copper(ii) complexes [CuL1] (1) and [CuL2] (2) derived from azo-based ligands 2-hydroxy-5-p-tolylazo-benzaldehyde (HL1) and 1-(2-hydroxy-5-p-tolylazo-phenyl)-ethan-one (HL2) were synthesized. These two ligands and their metal complexes were characterized by elemental analysis, nuclear magnetic resonance (1H and 13C), infrared, and UV/Vis spectroscopic techniques. Spectroscopy and other theoretical studies reveal the geometry of copper complexes, and their binding affinity towards nucleic acids are major groove binding. |
| first_indexed | 2024-04-12T00:20:57Z |
| format | Article |
| id | doaj.art-3300bde14d7548399c672cc732aa54e5 |
| institution | Directory Open Access Journal |
| issn | 2391-5420 |
| language | English |
| last_indexed | 2024-04-12T00:20:57Z |
| publishDate | 2022-06-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Open Chemistry |
| spelling | doaj.art-3300bde14d7548399c672cc732aa54e52022-12-22T03:55:43ZengDe GruyterOpen Chemistry2391-54202022-06-0120150551610.1515/chem-2022-0164Copper(ii) complexes supported by modified azo-based ligands: Nucleic acid binding and molecular docking studiesTripathi Mamta0Asatkar Ashish Kumar1Antony Stalin2Dash Mrinal Kanti3Roymahapatra Gourisankar4Pande Rama5Sarkar Avijit6Aldakheel Fahad M.7Binshaya Abdulkarim S.8Alharthi Nahed S.9Alaofi Ahmed L.10Alqahtani Mohammed S.11Syed Rabbani12School of Studies in Chemistry, Pt. Ravishankar Shukla University, Raipur, 492010, Chhattisgarh, IndiaDepartment of Chemistry, Government Gundadhur P. G. College, Kondagaon, 494226, Chhattisgarh, IndiaDepartment of Traditional Chinese Medicine, State Key Laboratory of Subtropical Silviculture, Zhejiang A&F University, Hangzhou, 311300, ChinaDepartment of Applied Sciences, Haldia Institute of Technology, Haldia, 721657, IndiaDepartment of Applied Sciences, Haldia Institute of Technology, Haldia, 721657, IndiaSchool of Studies in Chemistry, Pt. Ravishankar Shukla University, Raipur, 492010, Chhattisgarh, IndiaDepartment of Chemistry, Bhairab Ganguly College, Belghoria, Kolkata, 700056, IndiaDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, 11433, Saudi ArabiaDepartment of Medical Laboratory Sciences, College of Medical Sciences, Prince Sattam bin Abdulaziz University (PSAU), Alkharz, Saudi ArabiaDepartment of Medical Laboratory Sciences, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University (PSAU), Alkharj, Saudi ArabiaDepartment of Pharmaceutics, College of Pharmacy, King Saud University, P.O Box. 2457, Riyadh, 11451, Kingdom of Saudi ArabiaDepartment of Pharmaceutics, College of Pharmacy, King Saud University, P.O Box. 2457, Riyadh, 11451, Kingdom of Saudi ArabiaDepartment of Pharmaceutics, College of Pharmacy, King Saud University, P.O Box. 2457, Riyadh, 11451, Kingdom of Saudi ArabiaTwo new copper(ii) complexes [CuL1] (1) and [CuL2] (2) derived from azo-based ligands 2-hydroxy-5-p-tolylazo-benzaldehyde (HL1) and 1-(2-hydroxy-5-p-tolylazo-phenyl)-ethan-one (HL2) were synthesized. These two ligands and their metal complexes were characterized by elemental analysis, nuclear magnetic resonance (1H and 13C), infrared, and UV/Vis spectroscopic techniques. Spectroscopy and other theoretical studies reveal the geometry of copper complexes, and their binding affinity towards nucleic acids are major groove binding.https://doi.org/10.1515/chem-2022-0164azocopper(ii) complexesdftct-dnat-rnamolecular docking |
| spellingShingle | Tripathi Mamta Asatkar Ashish Kumar Antony Stalin Dash Mrinal Kanti Roymahapatra Gourisankar Pande Rama Sarkar Avijit Aldakheel Fahad M. Binshaya Abdulkarim S. Alharthi Nahed S. Alaofi Ahmed L. Alqahtani Mohammed S. Syed Rabbani Copper(ii) complexes supported by modified azo-based ligands: Nucleic acid binding and molecular docking studies Open Chemistry azo copper(ii) complexes dft ct-dna t-rna molecular docking |
| title | Copper(ii) complexes supported by modified azo-based ligands: Nucleic acid binding and molecular docking studies |
| title_full | Copper(ii) complexes supported by modified azo-based ligands: Nucleic acid binding and molecular docking studies |
| title_fullStr | Copper(ii) complexes supported by modified azo-based ligands: Nucleic acid binding and molecular docking studies |
| title_full_unstemmed | Copper(ii) complexes supported by modified azo-based ligands: Nucleic acid binding and molecular docking studies |
| title_short | Copper(ii) complexes supported by modified azo-based ligands: Nucleic acid binding and molecular docking studies |
| title_sort | copper ii complexes supported by modified azo based ligands nucleic acid binding and molecular docking studies |
| topic | azo copper(ii) complexes dft ct-dna t-rna molecular docking |
| url | https://doi.org/10.1515/chem-2022-0164 |
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