| Summary: | Summary: Cochlear amplification denotes a boost to auditory sensitivity and selectivity that is dependent on outer hair cells from Corti's organ. Voltage-driven electromotility of the cell is believed to feed energy back into the cochlear partition via a cycle-by-cycle mechanism at very high acoustic frequencies. Here we show using wide-band macro-patch voltage-clamp to drive prestin, the molecular motor underlying electromotility, that its voltage-sensor charge movement is unusually low pass in nature, being incapable of following high-frequency voltage changes. Our data are incompatible with a cycle-by-cycle mechanism responsible for high-frequency tuning in mammals. : Auditory Evoked Response; Bioelectronics; Mechanobiology Subject Areas: Auditory Evoked Response, Bioelectronics, Mechanobiology
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