EVALUATION OF T LYMPHOCYTE SUBSETS IN CHILDREN WITH BETA THALASSEMIA MAJOR
Peripheral blood T lymphocytes and their subsets were studied in 31 patients with beta thalassemia major (age 2-12years) and compared with 14 age-arid sex-matched healthy controls. Three monoclonal antibodies (anti-CD3, anti CD-f, unti-CDS) were simultaneously applied for detection of Th (CD3-, CD4^...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
1999-06-01
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| Series: | Acta Medica Iranica |
| Subjects: | |
| Online Access: | https://acta.tums.ac.ir/index.php/acta/article/view/1774 |
| _version_ | 1818806870828122112 |
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| author | A. Danesh M. Mir-Ahmadian |
| author_facet | A. Danesh M. Mir-Ahmadian |
| author_sort | A. Danesh |
| collection | DOAJ |
| description | Peripheral blood T lymphocytes and their subsets were studied in 31 patients with beta thalassemia major (age 2-12years) and compared with 14 age-arid sex-matched healthy controls. Three monoclonal antibodies (anti-CD3, anti CD-f, unti-CDS) were simultaneously applied for detection of Th (CD3-, CD4^), Tsk (CD3+, CD8+) and Th/Ts ratio by flow-cytometry respectively. The results of this study showed a slight increase in the number of Tlymphocytes, T 004^, TCDS+, and CD4'*/CDS* ratio; but this increase was not statistically significant (P>0.05). No primary defect in Tcell subsets was detected and it was suggested that continuous regulation of iron balance is an important factor in decreasing immunological disturbance. |
| first_indexed | 2024-12-18T19:16:39Z |
| format | Article |
| id | doaj.art-33040831e06045979a0588e0579034da |
| institution | Directory Open Access Journal |
| issn | 0044-6025 1735-9694 |
| language | English |
| last_indexed | 2024-12-18T19:16:39Z |
| publishDate | 1999-06-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Acta Medica Iranica |
| spelling | doaj.art-33040831e06045979a0588e0579034da2022-12-21T20:56:06ZengTehran University of Medical SciencesActa Medica Iranica0044-60251735-96941999-06-01372EVALUATION OF T LYMPHOCYTE SUBSETS IN CHILDREN WITH BETA THALASSEMIA MAJOR A. Danesh0 M. Mir-Ahmadian 1 Peripheral blood T lymphocytes and their subsets were studied in 31 patients with beta thalassemia major (age 2-12years) and compared with 14 age-arid sex-matched healthy controls. Three monoclonal antibodies (anti-CD3, anti CD-f, unti-CDS) were simultaneously applied for detection of Th (CD3-, CD4^), Tsk (CD3+, CD8+) and Th/Ts ratio by flow-cytometry respectively. The results of this study showed a slight increase in the number of Tlymphocytes, T 004^, TCDS+, and CD4'*/CDS* ratio; but this increase was not statistically significant (P>0.05). No primary defect in Tcell subsets was detected and it was suggested that continuous regulation of iron balance is an important factor in decreasing immunological disturbance.https://acta.tums.ac.ir/index.php/acta/article/view/1774Beta thalassemia majorT cell subsets |
| spellingShingle | A. Danesh M. Mir-Ahmadian EVALUATION OF T LYMPHOCYTE SUBSETS IN CHILDREN WITH BETA THALASSEMIA MAJOR Acta Medica Iranica Beta thalassemia major T cell subsets |
| title | EVALUATION OF T LYMPHOCYTE SUBSETS IN CHILDREN WITH BETA THALASSEMIA MAJOR |
| title_full | EVALUATION OF T LYMPHOCYTE SUBSETS IN CHILDREN WITH BETA THALASSEMIA MAJOR |
| title_fullStr | EVALUATION OF T LYMPHOCYTE SUBSETS IN CHILDREN WITH BETA THALASSEMIA MAJOR |
| title_full_unstemmed | EVALUATION OF T LYMPHOCYTE SUBSETS IN CHILDREN WITH BETA THALASSEMIA MAJOR |
| title_short | EVALUATION OF T LYMPHOCYTE SUBSETS IN CHILDREN WITH BETA THALASSEMIA MAJOR |
| title_sort | evaluation of t lymphocyte subsets in children with beta thalassemia major |
| topic | Beta thalassemia major T cell subsets |
| url | https://acta.tums.ac.ir/index.php/acta/article/view/1774 |
| work_keys_str_mv | AT adanesh evaluationoftlymphocytesubsetsinchildrenwithbetathalassemiamajor AT mmirahmadian evaluationoftlymphocytesubsetsinchildrenwithbetathalassemiamajor |