Human Thalamic-Prefrontal Peduncle Connectivity Revealed by Diffusion Spectrum Imaging Fiber Tracking
The thalamic-prefrontal peduncle (TPP) is a large bundle connecting the thalamus and prefrontal cortex. The definitive structure and function of the TPP are still controversial. To investigate the connectivity and segmentation patterns of the TPP, we employed diffusion spectrum imaging with generali...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2018-04-01
|
| Series: | Frontiers in Neuroanatomy |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fnana.2018.00024/full |
| _version_ | 1818171906196504576 |
|---|---|
| author | Chuanqi Sun Yibao Wang Run Cui Chong Wu Xinguo Li Yue Bao Yong Wang |
| author_facet | Chuanqi Sun Yibao Wang Run Cui Chong Wu Xinguo Li Yue Bao Yong Wang |
| author_sort | Chuanqi Sun |
| collection | DOAJ |
| description | The thalamic-prefrontal peduncle (TPP) is a large bundle connecting the thalamus and prefrontal cortex. The definitive structure and function of the TPP are still controversial. To investigate the connectivity and segmentation patterns of the TPP, we employed diffusion spectrum imaging with generalized q-sampling reconstruction to perform both subject-specific and template-based analyses. Our results confirmed the trajectory and spatial relationship of the TPP in the human brain and identified the connection areas in the prefrontal cortex. The TPP-connecting areas identified based on Brodmann areas (BAs) were BAs 8–11 and 45–47. Based on the automated anatomical atlas, these areas were the medial superior frontal gyrus, superior frontal gyrus, middle frontal gyrus, pars triangularis, pars orbitalis, anterior orbital gyrus, and lateral orbital gyrus. In addition, we identified the TPP connection areas in the thalamus, including the anterior and medial nuclei, and the lateral dorsal/lateral posterior nuclei. TPP fibers connected the thalamus with the ipsilateral prefrontal BAs 11, 47, 10, 46, 45, 9, and 8 seriatim from medial to lateral, layer by layer. Our results provide further details of the thalamic-prefrontal peduncle structure, and may aid future studies and a better understanding of the functional roles of the TPP in the human brain. |
| first_indexed | 2024-12-11T19:04:09Z |
| format | Article |
| id | doaj.art-33054762caad4250b129a1ad7d13c856 |
| institution | Directory Open Access Journal |
| issn | 1662-5129 |
| language | English |
| last_indexed | 2024-12-11T19:04:09Z |
| publishDate | 2018-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroanatomy |
| spelling | doaj.art-33054762caad4250b129a1ad7d13c8562022-12-22T00:53:56ZengFrontiers Media S.A.Frontiers in Neuroanatomy1662-51292018-04-011210.3389/fnana.2018.00024310549Human Thalamic-Prefrontal Peduncle Connectivity Revealed by Diffusion Spectrum Imaging Fiber TrackingChuanqi Sun0Yibao Wang1Run Cui2Chong Wu3Xinguo Li4Yue Bao5Yong Wang6Department of Innovative Medical Photonics, Preeminent Medical Photonics Education & Research Center, Institute for Photonics Research, Hamamatsu University School of Medicine, Hamamatsu, JapanDepartment of Neurosurgery, First Affiliated Hospital of China Medical University, Shenyang, ChinaDepartment of Neurosurgery, First Affiliated Hospital of China Medical University, Shenyang, ChinaDepartment of Neurosurgery, Anshan Central Hospital, Anshan, ChinaDepartment of Neurosurgery, First Affiliated Hospital of China Medical University, Shenyang, ChinaDepartment of Neurosurgery, First Affiliated Hospital of China Medical University, Shenyang, ChinaDepartment of Neurosurgery, First Affiliated Hospital of China Medical University, Shenyang, ChinaThe thalamic-prefrontal peduncle (TPP) is a large bundle connecting the thalamus and prefrontal cortex. The definitive structure and function of the TPP are still controversial. To investigate the connectivity and segmentation patterns of the TPP, we employed diffusion spectrum imaging with generalized q-sampling reconstruction to perform both subject-specific and template-based analyses. Our results confirmed the trajectory and spatial relationship of the TPP in the human brain and identified the connection areas in the prefrontal cortex. The TPP-connecting areas identified based on Brodmann areas (BAs) were BAs 8–11 and 45–47. Based on the automated anatomical atlas, these areas were the medial superior frontal gyrus, superior frontal gyrus, middle frontal gyrus, pars triangularis, pars orbitalis, anterior orbital gyrus, and lateral orbital gyrus. In addition, we identified the TPP connection areas in the thalamus, including the anterior and medial nuclei, and the lateral dorsal/lateral posterior nuclei. TPP fibers connected the thalamus with the ipsilateral prefrontal BAs 11, 47, 10, 46, 45, 9, and 8 seriatim from medial to lateral, layer by layer. Our results provide further details of the thalamic-prefrontal peduncle structure, and may aid future studies and a better understanding of the functional roles of the TPP in the human brain.http://journal.frontiersin.org/article/10.3389/fnana.2018.00024/fullthalamic-prefrontal pedunclediffusion spectrum imagingfiber tractographyconnectivity patternwhite matter |
| spellingShingle | Chuanqi Sun Yibao Wang Run Cui Chong Wu Xinguo Li Yue Bao Yong Wang Human Thalamic-Prefrontal Peduncle Connectivity Revealed by Diffusion Spectrum Imaging Fiber Tracking Frontiers in Neuroanatomy thalamic-prefrontal peduncle diffusion spectrum imaging fiber tractography connectivity pattern white matter |
| title | Human Thalamic-Prefrontal Peduncle Connectivity Revealed by Diffusion Spectrum Imaging Fiber Tracking |
| title_full | Human Thalamic-Prefrontal Peduncle Connectivity Revealed by Diffusion Spectrum Imaging Fiber Tracking |
| title_fullStr | Human Thalamic-Prefrontal Peduncle Connectivity Revealed by Diffusion Spectrum Imaging Fiber Tracking |
| title_full_unstemmed | Human Thalamic-Prefrontal Peduncle Connectivity Revealed by Diffusion Spectrum Imaging Fiber Tracking |
| title_short | Human Thalamic-Prefrontal Peduncle Connectivity Revealed by Diffusion Spectrum Imaging Fiber Tracking |
| title_sort | human thalamic prefrontal peduncle connectivity revealed by diffusion spectrum imaging fiber tracking |
| topic | thalamic-prefrontal peduncle diffusion spectrum imaging fiber tractography connectivity pattern white matter |
| url | http://journal.frontiersin.org/article/10.3389/fnana.2018.00024/full |
| work_keys_str_mv | AT chuanqisun humanthalamicprefrontalpeduncleconnectivityrevealedbydiffusionspectrumimagingfibertracking AT yibaowang humanthalamicprefrontalpeduncleconnectivityrevealedbydiffusionspectrumimagingfibertracking AT runcui humanthalamicprefrontalpeduncleconnectivityrevealedbydiffusionspectrumimagingfibertracking AT chongwu humanthalamicprefrontalpeduncleconnectivityrevealedbydiffusionspectrumimagingfibertracking AT xinguoli humanthalamicprefrontalpeduncleconnectivityrevealedbydiffusionspectrumimagingfibertracking AT yuebao humanthalamicprefrontalpeduncleconnectivityrevealedbydiffusionspectrumimagingfibertracking AT yongwang humanthalamicprefrontalpeduncleconnectivityrevealedbydiffusionspectrumimagingfibertracking |