Corneal endothelial cells and corneal thickness in congenital cataract patients
AIM: To assess corneal endothelial cells and corneal thickness in congenital cataract patients, which contributes to studying the characteristics and mechanism of the disease.<p>METHODS: From August 2014 to December 2018, 141 patients diagnosed with congenital cataract before surgery in our ho...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2019-10-01
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| Series: | Guoji Yanke Zazhi |
| Subjects: | |
| Online Access: | http://ies.ijo.cn/cn_publish/2019/10/201910022.pdf |
| _version_ | 1819021650789662720 |
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| author | Jin-Chao Liu Bing-Kai Feng Jing-Jing Su Shi-Dan Wang Long-Hao Kuang Qi-Gao Feng |
| author_facet | Jin-Chao Liu Bing-Kai Feng Jing-Jing Su Shi-Dan Wang Long-Hao Kuang Qi-Gao Feng |
| author_sort | Jin-Chao Liu |
| collection | DOAJ |
| description | AIM: To assess corneal endothelial cells and corneal thickness in congenital cataract patients, which contributes to studying the characteristics and mechanism of the disease.<p>METHODS: From August 2014 to December 2018, 141 patients diagnosed with congenital cataract before surgery in our hospital were analyzed retrospectively. Their endothelial cell density(ECD), average size(AVE), standard deviation of size(SD), coefficient of variation(CV), Hexagonality(Hex)and central corneal thickness(CCT)were measured with non-contact specular microscope. The data were statistically analyzed using partial correlation analysis to detect the correlation among patients' ECD, AVE, SD, CV, Hex, CCT and age, and we conducted curve fitting with multiple stepwise regression. We compared male and female patients', bilateral and unilateral cataract's parameters above by covariance analysis.<p>RESULTS: The correlation between patients' ECD, AVE, SD and age was significant, and the fitting curve was obtained with equation ECD=3957.33-306.62×ln(age)、AVE=178.77+27.39×ln(age)and SD=77.13×e0.013×age respectively. CV was significantly greater in female patients than that in male patients(<i>P</i>=0.044). SD and CV was significantly greater in right eyes of bilateral cataract than that in affected eyes(<i>P</i>=0.037, <i>P</i>=0.028 respectively)and healthy eyes(<i>P</i>=0.007, <i>P</i>=0.003 respectively)from unilateral cataract, Hex was significantly less in right eyes of bilateral cataract than that in affected eyes(<i>P</i>=0.006)and healthy eyes(<i>P</i>=0.009)from unilateral cataract, CCT was significantly greater in right eyes of bilateral cataract than that in healthy eyes(<i>P</i>=0.041)from unilateral cataract.<p>CONCLUSION: Congenital cataract may affect corneal endothelial cells and corneal thickness, especially SD, CV, Hex and CCT. Patients' ECD, AVE and SD changes with age. Female patients may have greater CV than male patients. |
| first_indexed | 2024-12-21T04:10:29Z |
| format | Article |
| id | doaj.art-3305b2f0717c4ff5827c44caf13f97f4 |
| institution | Directory Open Access Journal |
| issn | 1672-5123 1672-5123 |
| language | English |
| last_indexed | 2024-12-21T04:10:29Z |
| publishDate | 2019-10-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | Guoji Yanke Zazhi |
| spelling | doaj.art-3305b2f0717c4ff5827c44caf13f97f42022-12-21T19:16:28ZengPress of International Journal of Ophthalmology (IJO PRESS)Guoji Yanke Zazhi1672-51231672-51232019-10-0119101733173710.3980/j.issn.1672-5123.2019.10.22Corneal endothelial cells and corneal thickness in congenital cataract patientsJin-Chao Liu0Bing-Kai Feng1Jing-Jing Su2Shi-Dan Wang3Long-Hao Kuang4Qi-Gao Feng5Shenzhen Eye Hospital; School of Optometry, Shenzhen University; Shenzhen Eye Hospital Affiliated to Jinan University; Shenzhen Key Laboratory of Ophthalmology, Shenzhen 518040, Guangdong Province, ChinaShenzhen Eye Hospital; School of Optometry, Shenzhen University; Shenzhen Eye Hospital Affiliated to Jinan University; Shenzhen Key Laboratory of Ophthalmology, Shenzhen 518040, Guangdong Province, ChinaShenzhen Eye Hospital; School of Optometry, Shenzhen University; Shenzhen Eye Hospital Affiliated to Jinan University; Shenzhen Key Laboratory of Ophthalmology, Shenzhen 518040, Guangdong Province, ChinaShenzhen Eye Hospital; School of Optometry, Shenzhen University; Shenzhen Eye Hospital Affiliated to Jinan University; Shenzhen Key Laboratory of Ophthalmology, Shenzhen 518040, Guangdong Province, ChinaShenzhen Eye Hospital; School of Optometry, Shenzhen University; Shenzhen Eye Hospital Affiliated to Jinan University; Shenzhen Key Laboratory of Ophthalmology, Shenzhen 518040, Guangdong Province, ChinaShenzhen Eye Hospital; School of Optometry, Shenzhen University; Shenzhen Eye Hospital Affiliated to Jinan University; Shenzhen Key Laboratory of Ophthalmology, Shenzhen 518040, Guangdong Province, ChinaAIM: To assess corneal endothelial cells and corneal thickness in congenital cataract patients, which contributes to studying the characteristics and mechanism of the disease.<p>METHODS: From August 2014 to December 2018, 141 patients diagnosed with congenital cataract before surgery in our hospital were analyzed retrospectively. Their endothelial cell density(ECD), average size(AVE), standard deviation of size(SD), coefficient of variation(CV), Hexagonality(Hex)and central corneal thickness(CCT)were measured with non-contact specular microscope. The data were statistically analyzed using partial correlation analysis to detect the correlation among patients' ECD, AVE, SD, CV, Hex, CCT and age, and we conducted curve fitting with multiple stepwise regression. We compared male and female patients', bilateral and unilateral cataract's parameters above by covariance analysis.<p>RESULTS: The correlation between patients' ECD, AVE, SD and age was significant, and the fitting curve was obtained with equation ECD=3957.33-306.62×ln(age)、AVE=178.77+27.39×ln(age)and SD=77.13×e0.013×age respectively. CV was significantly greater in female patients than that in male patients(<i>P</i>=0.044). SD and CV was significantly greater in right eyes of bilateral cataract than that in affected eyes(<i>P</i>=0.037, <i>P</i>=0.028 respectively)and healthy eyes(<i>P</i>=0.007, <i>P</i>=0.003 respectively)from unilateral cataract, Hex was significantly less in right eyes of bilateral cataract than that in affected eyes(<i>P</i>=0.006)and healthy eyes(<i>P</i>=0.009)from unilateral cataract, CCT was significantly greater in right eyes of bilateral cataract than that in healthy eyes(<i>P</i>=0.041)from unilateral cataract.<p>CONCLUSION: Congenital cataract may affect corneal endothelial cells and corneal thickness, especially SD, CV, Hex and CCT. Patients' ECD, AVE and SD changes with age. Female patients may have greater CV than male patients.http://ies.ijo.cn/cn_publish/2019/10/201910022.pdfcongenital cataractendothelial cell densityaverage sizestandard deviation of sizecoefficient of variationHexagonalitycentral corneal thickness |
| spellingShingle | Jin-Chao Liu Bing-Kai Feng Jing-Jing Su Shi-Dan Wang Long-Hao Kuang Qi-Gao Feng Corneal endothelial cells and corneal thickness in congenital cataract patients Guoji Yanke Zazhi congenital cataract endothelial cell density average size standard deviation of size coefficient of variation Hexagonality central corneal thickness |
| title | Corneal endothelial cells and corneal thickness in congenital cataract patients |
| title_full | Corneal endothelial cells and corneal thickness in congenital cataract patients |
| title_fullStr | Corneal endothelial cells and corneal thickness in congenital cataract patients |
| title_full_unstemmed | Corneal endothelial cells and corneal thickness in congenital cataract patients |
| title_short | Corneal endothelial cells and corneal thickness in congenital cataract patients |
| title_sort | corneal endothelial cells and corneal thickness in congenital cataract patients |
| topic | congenital cataract endothelial cell density average size standard deviation of size coefficient of variation Hexagonality central corneal thickness |
| url | http://ies.ijo.cn/cn_publish/2019/10/201910022.pdf |
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