Dynamic changes in arterial blood gas during cardiopulmonary resuscitation in out-of-hospital cardiac arrest
Abstract We aimed to investigate the prognostic value of dynamic changes in arterial blood gas analysis (ABGA) measured after the start of cardiopulmonary resuscitation (CPR) for return of spontaneous circulation (ROSC) in patients with out-of-hospital cardiac arrest (OHCA). This prospective observa...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-11-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-02764-4 |
| _version_ | 1818402576385703936 |
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| author | Seok-In Hong June-Sung Kim Youn-Jung Kim Won Young Kim |
| author_facet | Seok-In Hong June-Sung Kim Youn-Jung Kim Won Young Kim |
| author_sort | Seok-In Hong |
| collection | DOAJ |
| description | Abstract We aimed to investigate the prognostic value of dynamic changes in arterial blood gas analysis (ABGA) measured after the start of cardiopulmonary resuscitation (CPR) for return of spontaneous circulation (ROSC) in patients with out-of-hospital cardiac arrest (OHCA). This prospective observational study was conducted at the emergency department of a university hospital from February 2018 to February 2020. All blood samples for gas analysis were collected from a radial or femoral arterial line, which was inserted during CPR. Changes in ABGA parameters were expressed as delta (Δ), defined as the values of the second ABGA minus the values of the initial ABGA. The primary outcome was sustained ROSC. Out of the 80 patients included in the analysis, 13 achieved sustained ROSC after in-hospital resuscitation. Multivariable logistic analysis revealed that ΔpaO2 (odds ratio [OR] = 1.023; 95% confidence interval [CI] = 1.004–1.043, p = 0.020) along with prehospital shockable rhythm (OR = 84.680; 95% CI = 2.561–2799.939, p = 0.013) and total resuscitation duration (OR = 0.881; 95% CI = 0.805–0.964, p = 0.006) were significant predictors for sustained ROSC. Our study suggests a possible association between ΔpaO2 in ABGA during CPR and an increased rate of sustained ROSC in the late phase of OHCA. |
| first_indexed | 2024-12-14T08:10:33Z |
| format | Article |
| id | doaj.art-33093bde484546688694f58298715d4f |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-14T08:10:33Z |
| publishDate | 2021-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-33093bde484546688694f58298715d4f2022-12-21T23:10:05ZengNature PortfolioScientific Reports2045-23222021-11-011111910.1038/s41598-021-02764-4Dynamic changes in arterial blood gas during cardiopulmonary resuscitation in out-of-hospital cardiac arrestSeok-In Hong0June-Sung Kim1Youn-Jung Kim2Won Young Kim3Department of Emergency Medicine, Asan Medical Center, University of Ulsan College of MedicineDepartment of Emergency Medicine, Asan Medical Center, University of Ulsan College of MedicineDepartment of Emergency Medicine, Asan Medical Center, University of Ulsan College of MedicineDepartment of Emergency Medicine, Asan Medical Center, University of Ulsan College of MedicineAbstract We aimed to investigate the prognostic value of dynamic changes in arterial blood gas analysis (ABGA) measured after the start of cardiopulmonary resuscitation (CPR) for return of spontaneous circulation (ROSC) in patients with out-of-hospital cardiac arrest (OHCA). This prospective observational study was conducted at the emergency department of a university hospital from February 2018 to February 2020. All blood samples for gas analysis were collected from a radial or femoral arterial line, which was inserted during CPR. Changes in ABGA parameters were expressed as delta (Δ), defined as the values of the second ABGA minus the values of the initial ABGA. The primary outcome was sustained ROSC. Out of the 80 patients included in the analysis, 13 achieved sustained ROSC after in-hospital resuscitation. Multivariable logistic analysis revealed that ΔpaO2 (odds ratio [OR] = 1.023; 95% confidence interval [CI] = 1.004–1.043, p = 0.020) along with prehospital shockable rhythm (OR = 84.680; 95% CI = 2.561–2799.939, p = 0.013) and total resuscitation duration (OR = 0.881; 95% CI = 0.805–0.964, p = 0.006) were significant predictors for sustained ROSC. Our study suggests a possible association between ΔpaO2 in ABGA during CPR and an increased rate of sustained ROSC in the late phase of OHCA.https://doi.org/10.1038/s41598-021-02764-4 |
| spellingShingle | Seok-In Hong June-Sung Kim Youn-Jung Kim Won Young Kim Dynamic changes in arterial blood gas during cardiopulmonary resuscitation in out-of-hospital cardiac arrest Scientific Reports |
| title | Dynamic changes in arterial blood gas during cardiopulmonary resuscitation in out-of-hospital cardiac arrest |
| title_full | Dynamic changes in arterial blood gas during cardiopulmonary resuscitation in out-of-hospital cardiac arrest |
| title_fullStr | Dynamic changes in arterial blood gas during cardiopulmonary resuscitation in out-of-hospital cardiac arrest |
| title_full_unstemmed | Dynamic changes in arterial blood gas during cardiopulmonary resuscitation in out-of-hospital cardiac arrest |
| title_short | Dynamic changes in arterial blood gas during cardiopulmonary resuscitation in out-of-hospital cardiac arrest |
| title_sort | dynamic changes in arterial blood gas during cardiopulmonary resuscitation in out of hospital cardiac arrest |
| url | https://doi.org/10.1038/s41598-021-02764-4 |
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