The Relationship between Autism Spectrum Disorder and Melatonin during Fetal Development
The aim of this review is to clarify the interrelationship between melatonin and autism spectrum disorder (ASD) during fetal development. ASD refers to a diverse range of neurodevelopmental disorders characterized by social deficits, impaired communication, and stereotyped or repetitive behaviors. M...
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| Format: | Article |
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MDPI AG
2018-01-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/23/1/198 |
| _version_ | 1811268281754976256 |
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| author | Yunho Jin Jeonghyun Choi Jinyoung Won Yonggeun Hong |
| author_facet | Yunho Jin Jeonghyun Choi Jinyoung Won Yonggeun Hong |
| author_sort | Yunho Jin |
| collection | DOAJ |
| description | The aim of this review is to clarify the interrelationship between melatonin and autism spectrum disorder (ASD) during fetal development. ASD refers to a diverse range of neurodevelopmental disorders characterized by social deficits, impaired communication, and stereotyped or repetitive behaviors. Melatonin, which is secreted by the pineal gland, has well-established neuroprotective and circadian entraining effects. During pregnancy, the hormone crosses the placenta into the fetal circulation and transmits photoperiodic information to the fetus allowing the establishment of normal sleep patterns and circadian rhythms that are essential for normal neurodevelopment. Melatonin synthesis is frequently impaired in patients with ASD. The hormone reduces oxidative stress, which is harmful to the central nervous system. Therefore, the neuroprotective and circadian entraining roles of melatonin may reduce the risk of neurodevelopmental disorders such as ASD. |
| first_indexed | 2024-04-12T21:18:54Z |
| format | Article |
| id | doaj.art-3309f828198d4c0fa52254b3052e04a3 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-04-12T21:18:54Z |
| publishDate | 2018-01-01 |
| publisher | MDPI AG |
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| series | Molecules |
| spelling | doaj.art-3309f828198d4c0fa52254b3052e04a32022-12-22T03:16:21ZengMDPI AGMolecules1420-30492018-01-0123119810.3390/molecules23010198molecules23010198The Relationship between Autism Spectrum Disorder and Melatonin during Fetal DevelopmentYunho Jin0Jeonghyun Choi1Jinyoung Won2Yonggeun Hong3Department of Rehabilitation Science, Graduate School of Inje University, Gimhae 50834, KoreaDepartment of Rehabilitation Science, Graduate School of Inje University, Gimhae 50834, KoreaUbiquitous Healthcare & Anti-aging Research Center (u-HARC), Inje University, Gimhae 50834, KoreaDepartment of Rehabilitation Science, Graduate School of Inje University, Gimhae 50834, KoreaThe aim of this review is to clarify the interrelationship between melatonin and autism spectrum disorder (ASD) during fetal development. ASD refers to a diverse range of neurodevelopmental disorders characterized by social deficits, impaired communication, and stereotyped or repetitive behaviors. Melatonin, which is secreted by the pineal gland, has well-established neuroprotective and circadian entraining effects. During pregnancy, the hormone crosses the placenta into the fetal circulation and transmits photoperiodic information to the fetus allowing the establishment of normal sleep patterns and circadian rhythms that are essential for normal neurodevelopment. Melatonin synthesis is frequently impaired in patients with ASD. The hormone reduces oxidative stress, which is harmful to the central nervous system. Therefore, the neuroprotective and circadian entraining roles of melatonin may reduce the risk of neurodevelopmental disorders such as ASD.http://www.mdpi.com/1420-3049/23/1/198autism spectrum disordermelatoninfetal developmentneuroprotectioncircadian rhythm |
| spellingShingle | Yunho Jin Jeonghyun Choi Jinyoung Won Yonggeun Hong The Relationship between Autism Spectrum Disorder and Melatonin during Fetal Development Molecules autism spectrum disorder melatonin fetal development neuroprotection circadian rhythm |
| title | The Relationship between Autism Spectrum Disorder and Melatonin during Fetal Development |
| title_full | The Relationship between Autism Spectrum Disorder and Melatonin during Fetal Development |
| title_fullStr | The Relationship between Autism Spectrum Disorder and Melatonin during Fetal Development |
| title_full_unstemmed | The Relationship between Autism Spectrum Disorder and Melatonin during Fetal Development |
| title_short | The Relationship between Autism Spectrum Disorder and Melatonin during Fetal Development |
| title_sort | relationship between autism spectrum disorder and melatonin during fetal development |
| topic | autism spectrum disorder melatonin fetal development neuroprotection circadian rhythm |
| url | http://www.mdpi.com/1420-3049/23/1/198 |
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