Gene gating at nuclear pores prevents the formation of R loops
Transcription is an important source of genetic variability. A large amount of transcription-associated genome variation arises from the unscheduled formation of R loops. We have recently found that physical proximity of chromatin to nuclear pores prevents the formation of pathological R loops durin...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2018-01-01
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| Series: | Molecular & Cellular Oncology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/23723556.2017.1405140 |
| _version_ | 1827809395179782144 |
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| author | Hélène Gaillard Francisco García-Benítez Andrés Aguilera |
| author_facet | Hélène Gaillard Francisco García-Benítez Andrés Aguilera |
| author_sort | Hélène Gaillard |
| collection | DOAJ |
| description | Transcription is an important source of genetic variability. A large amount of transcription-associated genome variation arises from the unscheduled formation of R loops. We have recently found that physical proximity of chromatin to nuclear pores prevents the formation of pathological R loops during transcription. Our study opens new perspectives to understand genome stability as a function of nuclear location. |
| first_indexed | 2024-03-11T22:40:34Z |
| format | Article |
| id | doaj.art-3309ff363ad046a081b3f4e47c78e231 |
| institution | Directory Open Access Journal |
| issn | 2372-3556 |
| language | English |
| last_indexed | 2024-03-11T22:40:34Z |
| publishDate | 2018-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Molecular & Cellular Oncology |
| spelling | doaj.art-3309ff363ad046a081b3f4e47c78e2312023-09-22T09:10:59ZengTaylor & Francis GroupMolecular & Cellular Oncology2372-35562018-01-015110.1080/23723556.2017.14051401405140Gene gating at nuclear pores prevents the formation of R loopsHélène Gaillard0Francisco García-Benítez1Andrés Aguilera2Centro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER, Universidad de Sevilla-CSIC-Universidad Pablo de OlavideCentro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER, Universidad de Sevilla-CSIC-Universidad Pablo de OlavideCentro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER, Universidad de Sevilla-CSIC-Universidad Pablo de OlavideTranscription is an important source of genetic variability. A large amount of transcription-associated genome variation arises from the unscheduled formation of R loops. We have recently found that physical proximity of chromatin to nuclear pores prevents the formation of pathological R loops during transcription. Our study opens new perspectives to understand genome stability as a function of nuclear location.http://dx.doi.org/10.1080/23723556.2017.1405140genome instabilitygenome organizationnuclear poresr looptranscription |
| spellingShingle | Hélène Gaillard Francisco García-Benítez Andrés Aguilera Gene gating at nuclear pores prevents the formation of R loops Molecular & Cellular Oncology genome instability genome organization nuclear pores r loop transcription |
| title | Gene gating at nuclear pores prevents the formation of R loops |
| title_full | Gene gating at nuclear pores prevents the formation of R loops |
| title_fullStr | Gene gating at nuclear pores prevents the formation of R loops |
| title_full_unstemmed | Gene gating at nuclear pores prevents the formation of R loops |
| title_short | Gene gating at nuclear pores prevents the formation of R loops |
| title_sort | gene gating at nuclear pores prevents the formation of r loops |
| topic | genome instability genome organization nuclear pores r loop transcription |
| url | http://dx.doi.org/10.1080/23723556.2017.1405140 |
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