Breadth of Antibodies to Plasmodium falciparum Variant Surface Antigens Is Associated With Immunity in a Controlled Human Malaria Infection Study

Breadth of Antibodies to Plasmodium falciparum Variant Surface Antigens Is Associated With Immunity in a Controlled Human Malaria Infection Study

BackgroundPlasmodium falciparum variant surface antigens (VSAs) contribute to malaria pathogenesis by mediating cytoadhesion of infected red blood cells to the microvasculature endothelium. In this study, we investigated the association between anti-VSA antibodies and clinical outcome in a controlle...

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Main Authors: Hannah W. Kimingi, Ann W. Kinyua, Nicole A. Achieng, Kennedy M. Wambui, Shaban Mwangi, Roselyne Nguti, Cheryl A. Kivisi, Anja T. R. Jensen, Philip Bejon, Melisa C. Kapulu, Abdirahman I. Abdi, Samson M. Kinyanjui, CHMI-SIKA Study Team, Abdirahman I Abdi, Yonas Abebe, Agnes Audi, Peter Billingsley, Peter C Bull, Primus Che, Zaydah de Laurent, Susanne H Hodgson, Stephen Hoffman, Eric James, Irene Jao, Dorcas Kamuya, Gathoni Kamuyu, Silvia Kariuki, Nelson Kibinge, Sam Kinyanjui, Cheryl Kivisi, Nelly Koskei, Mallika Imwong, Brett Lowe, Johnstone Makale, Kevin Marsh, Vicki Marsh, Khadija Said Mohammed, Moses Mosobo, Sean C Murphy, Jennifer Musyoki, Michelle Muthui, Jedidah Mwacharo, Daniel Mwanga, Joyce Mwongeli, Francis Ndungu, Maureen Njue, George Nyangweso, Domitila Kimani, Joyce M. Ngoi, Janet Musembi, Omar Ngoto, Edward Otieno, Bernhards Ogutu, Fredrick Olewe, James Oloo, Donwilliams Omuoyo, John Ongecha, Martin O Ongas, Michael Ooko, Jimmy Shangala, Betty Kim Lee Sim, Joel Tarning, Juliana Wambua, Thomas N Williams, Markus Winterberg
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Immunology
Subjects:
malaria
Plasmodium falciparum
CHMI
variant surface antigens
anti-VSA antibodies
antibody breadth
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.894770/full

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