Texosome-based drug delivery system for cancer therapy: from past to present
Rising worldwide cancer incidence and resistance to current anti-cancer drugs necessitate the need for new pharmaceutical compounds and drug delivery system. Malfunction of the immune system, particularly in the tumor microenvironment, causes tumor growth and enhances tumor progression. Thus, cancer...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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China Anti-Cancer Association
2015-09-01
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| Series: | Cancer Biology & Medicine |
| Subjects: | |
| Online Access: | http://www.cancerbiomed.org/index.php/cocr/article/view/867 |
| _version_ | 1818138423462985728 |
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| author | Hamideh Mahmoodzadeh Hosseini Raheleh Halabian Mohsen Amin Abbas Ali Imani Fooladi |
| author_facet | Hamideh Mahmoodzadeh Hosseini Raheleh Halabian Mohsen Amin Abbas Ali Imani Fooladi |
| author_sort | Hamideh Mahmoodzadeh Hosseini |
| collection | DOAJ |
| description | Rising worldwide cancer incidence and resistance to current anti-cancer drugs necessitate the need for new pharmaceutical compounds and drug delivery system. Malfunction of the immune system, particularly in the tumor microenvironment, causes tumor growth and enhances tumor progression. Thus, cancer immunotherapy can be an appropriate approach to provoke the systemic immune system to combat tumor expansion. Texosomes, which are endogenous nanovesicles released by all tumor cells, contribute to cell-cell communication and modify the phenotypic features of recipient cells due to the texosomes' ability to transport biological components. For this reason, texosome-based delivery system can be a valuable strategy for therapeutic purposes. To improve the pharmaceutical behavior of this system and to facilitate its use in medical applications, biotechnology approaches and mimetic techniques have been utilized. In this review, we present the development history of texosome-based delivery systems and discuss the advantages and disadvantages of each system. |
| first_indexed | 2024-12-11T10:11:58Z |
| format | Article |
| id | doaj.art-330dd78d75aa4959bb42244464d77a84 |
| institution | Directory Open Access Journal |
| issn | 2095-3941 2095-3941 |
| language | English |
| last_indexed | 2024-12-11T10:11:58Z |
| publishDate | 2015-09-01 |
| publisher | China Anti-Cancer Association |
| record_format | Article |
| series | Cancer Biology & Medicine |
| spelling | doaj.art-330dd78d75aa4959bb42244464d77a842022-12-22T01:11:44ZengChina Anti-Cancer AssociationCancer Biology & Medicine2095-39412095-39412015-09-0112315016210.7497/j.issn.2095-3941.2015.00452015000045Texosome-based drug delivery system for cancer therapy: from past to presentHamideh Mahmoodzadeh Hosseini0Raheleh Halabian1Mohsen Amin2Abbas Ali Imani Fooladi3Applied Microbiology Research Center, Baqiyatallah University of Medical Sciences, Tehran 1435916471, Iran;Applied Microbiology Research Center, Baqiyatallah University of Medical Sciences, Tehran 1435916471, Iran;Department of Drug and Food Control, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran 1417653861, IranApplied Microbiology Research Center, Baqiyatallah University of Medical Sciences, Tehran 1435916471, Iran;Rising worldwide cancer incidence and resistance to current anti-cancer drugs necessitate the need for new pharmaceutical compounds and drug delivery system. Malfunction of the immune system, particularly in the tumor microenvironment, causes tumor growth and enhances tumor progression. Thus, cancer immunotherapy can be an appropriate approach to provoke the systemic immune system to combat tumor expansion. Texosomes, which are endogenous nanovesicles released by all tumor cells, contribute to cell-cell communication and modify the phenotypic features of recipient cells due to the texosomes' ability to transport biological components. For this reason, texosome-based delivery system can be a valuable strategy for therapeutic purposes. To improve the pharmaceutical behavior of this system and to facilitate its use in medical applications, biotechnology approaches and mimetic techniques have been utilized. In this review, we present the development history of texosome-based delivery systems and discuss the advantages and disadvantages of each system.http://www.cancerbiomed.org/index.php/cocr/article/view/867Cancer therapytexosome mimetictumor microenvironmentimmunotherapy |
| spellingShingle | Hamideh Mahmoodzadeh Hosseini Raheleh Halabian Mohsen Amin Abbas Ali Imani Fooladi Texosome-based drug delivery system for cancer therapy: from past to present Cancer Biology & Medicine Cancer therapy texosome mimetic tumor microenvironment immunotherapy |
| title | Texosome-based drug delivery system for cancer therapy: from past to present |
| title_full | Texosome-based drug delivery system for cancer therapy: from past to present |
| title_fullStr | Texosome-based drug delivery system for cancer therapy: from past to present |
| title_full_unstemmed | Texosome-based drug delivery system for cancer therapy: from past to present |
| title_short | Texosome-based drug delivery system for cancer therapy: from past to present |
| title_sort | texosome based drug delivery system for cancer therapy from past to present |
| topic | Cancer therapy texosome mimetic tumor microenvironment immunotherapy |
| url | http://www.cancerbiomed.org/index.php/cocr/article/view/867 |
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