Causal effects of fatty acids on depression: Mendelian randomization study
ObjectivesFatty acids (FA) are widely believed to play a role in the pathophysiology of depression. However, the causal relationships between FA and depression remain elusive and warrant further research. We aimed to investigate the potential causal relationship between FA [saturated fatty acids (SF...
| Main Authors: | , , , , , , |
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| Format: | Article |
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Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2022.1010476/full |
| _version_ | 1811178495089311744 |
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| author | Lingsi Zeng Honggang Lv Xubo Wang Ranran Xue Cong Zhou Xia Liu Hao Yu |
| author_facet | Lingsi Zeng Honggang Lv Xubo Wang Ranran Xue Cong Zhou Xia Liu Hao Yu |
| author_sort | Lingsi Zeng |
| collection | DOAJ |
| description | ObjectivesFatty acids (FA) are widely believed to play a role in the pathophysiology of depression. However, the causal relationships between FA and depression remain elusive and warrant further research. We aimed to investigate the potential causal relationship between FA [saturated fatty acids (SFA), mono-unsaturated fatty acids (MUFA), and polyunsaturated fatty acids (PUFA)] and the risk of depression using Mendelian randomization (MR) analysis.MethodsWe conducted a two-sample MR analysis using large-scale European-based genome-wide association studies (GWASs) summary data related to depression (n = 500,199 individuals) and FA [saturated fatty acids (SFA), mono-unsaturated fatty acids (MUFA), and polyunsaturated fatty acids (PUFA)] levels. MR analysis was performed using the Wald ratio and inverse variance-weighted (IVW) methods, and sensitivity analysis was conducted by the simple mode, weighted mode, weighted median method, and MR-Egger method.ResultsWe found the causal effects for the levels of oleic acid (OA; OR = 1.07, p = 5.72 × 10–4), adrenic acid (OR = 0.74, p = 1.01 × 10–3), α-linolenic acid (ALA; OR = 2.52, p = 1.01 × 10–3), eicosapentaenoic acid (EPA; OR = 0.84, p = 3.11 × 10–3) on depression risk, after Bonferroni correction. The sensitivity analyses indicated similar trends. No causal effect between the levels of SFA and depression risk was observed.ConclusionOur study suggests that adrenic acid and EPA are protective against the risk of depression, while OA and ALA are potential risk factors for depression. Nonetheless, the underlying mechanisms that mediate the association between these FAs and depression risk should be investigated in further experiments. |
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| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-04-11T06:19:20Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-33123a6d6e3448c1863bb10fc0f2e8f72022-12-22T04:40:49ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2022-12-01910.3389/fnut.2022.10104761010476Causal effects of fatty acids on depression: Mendelian randomization studyLingsi Zeng0Honggang Lv1Xubo Wang2Ranran Xue3Cong Zhou4Xia Liu5Hao Yu6Department of Psychiatry, Jining Medical University, Jining, Shandong, ChinaDepartment of Psychiatry, Jining Medical University, Jining, Shandong, ChinaDepartment of Psychiatry, Shandong Daizhuang Hospital, Jining, Shandong, ChinaDepartment of Psychiatry, Shandong Daizhuang Hospital, Jining, Shandong, ChinaDepartment of Psychiatry, Jining Medical University, Jining, Shandong, ChinaDepartment of Sleep Medicine, Shandong Daizhuang Hospital, Jining, Shandong, ChinaDepartment of Psychiatry, Jining Medical University, Jining, Shandong, ChinaObjectivesFatty acids (FA) are widely believed to play a role in the pathophysiology of depression. However, the causal relationships between FA and depression remain elusive and warrant further research. We aimed to investigate the potential causal relationship between FA [saturated fatty acids (SFA), mono-unsaturated fatty acids (MUFA), and polyunsaturated fatty acids (PUFA)] and the risk of depression using Mendelian randomization (MR) analysis.MethodsWe conducted a two-sample MR analysis using large-scale European-based genome-wide association studies (GWASs) summary data related to depression (n = 500,199 individuals) and FA [saturated fatty acids (SFA), mono-unsaturated fatty acids (MUFA), and polyunsaturated fatty acids (PUFA)] levels. MR analysis was performed using the Wald ratio and inverse variance-weighted (IVW) methods, and sensitivity analysis was conducted by the simple mode, weighted mode, weighted median method, and MR-Egger method.ResultsWe found the causal effects for the levels of oleic acid (OA; OR = 1.07, p = 5.72 × 10–4), adrenic acid (OR = 0.74, p = 1.01 × 10–3), α-linolenic acid (ALA; OR = 2.52, p = 1.01 × 10–3), eicosapentaenoic acid (EPA; OR = 0.84, p = 3.11 × 10–3) on depression risk, after Bonferroni correction. The sensitivity analyses indicated similar trends. No causal effect between the levels of SFA and depression risk was observed.ConclusionOur study suggests that adrenic acid and EPA are protective against the risk of depression, while OA and ALA are potential risk factors for depression. Nonetheless, the underlying mechanisms that mediate the association between these FAs and depression risk should be investigated in further experiments.https://www.frontiersin.org/articles/10.3389/fnut.2022.1010476/fulldepressionMendelian randomizationfatty acids (FA)non-polyunsaturated fatty acids (non-PUFA)polyunsaturated fatty acids (PUFA)omega-3 fatty acids |
| spellingShingle | Lingsi Zeng Honggang Lv Xubo Wang Ranran Xue Cong Zhou Xia Liu Hao Yu Causal effects of fatty acids on depression: Mendelian randomization study Frontiers in Nutrition depression Mendelian randomization fatty acids (FA) non-polyunsaturated fatty acids (non-PUFA) polyunsaturated fatty acids (PUFA) omega-3 fatty acids |
| title | Causal effects of fatty acids on depression: Mendelian randomization study |
| title_full | Causal effects of fatty acids on depression: Mendelian randomization study |
| title_fullStr | Causal effects of fatty acids on depression: Mendelian randomization study |
| title_full_unstemmed | Causal effects of fatty acids on depression: Mendelian randomization study |
| title_short | Causal effects of fatty acids on depression: Mendelian randomization study |
| title_sort | causal effects of fatty acids on depression mendelian randomization study |
| topic | depression Mendelian randomization fatty acids (FA) non-polyunsaturated fatty acids (non-PUFA) polyunsaturated fatty acids (PUFA) omega-3 fatty acids |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2022.1010476/full |
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