Treatment of Autoimmune Bullous Diseases During Pregnancy and Lactation: A Review Focusing on Pemphigus and Pemphigoid Gestationis
Pregnancy may induce the onset or exacerbation of autoimmune bullous diseases such as pemphigus or pemphigoid gestationis. A shift toward T helper (Th) 2 immune response and the influence of hormonal changes have been evoked as possible triggering factors. Therapeutic management of this setting of p...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-10-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fphar.2020.583354/full |
| _version_ | 1818283879587381248 |
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| author | Giovanni Genovese Giovanni Genovese Federica Derlino Emilio Berti Emilio Berti Angelo Valerio Marzano Angelo Valerio Marzano |
| author_facet | Giovanni Genovese Giovanni Genovese Federica Derlino Emilio Berti Emilio Berti Angelo Valerio Marzano Angelo Valerio Marzano |
| author_sort | Giovanni Genovese |
| collection | DOAJ |
| description | Pregnancy may induce the onset or exacerbation of autoimmune bullous diseases such as pemphigus or pemphigoid gestationis. A shift toward T helper (Th) 2 immune response and the influence of hormonal changes have been evoked as possible triggering factors. Therapeutic management of this setting of patients may represent a challenge, mainly due to safety concerns of some immunosuppressive drugs during pregnancy and lactation. In this narrative review, we provided a comprehensive overview of the therapeutic management of autoimmune bullous diseases in pregnant and breastfeeding women, focusing on pemphigus and pemphigoid gestationis. |
| first_indexed | 2024-12-13T00:43:55Z |
| format | Article |
| id | doaj.art-33147e7a127845a69bfba83a6090f8a9 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-13T00:43:55Z |
| publishDate | 2020-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-33147e7a127845a69bfba83a6090f8a92022-12-22T00:05:05ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122020-10-011110.3389/fphar.2020.583354583354Treatment of Autoimmune Bullous Diseases During Pregnancy and Lactation: A Review Focusing on Pemphigus and Pemphigoid GestationisGiovanni Genovese0Giovanni Genovese1Federica Derlino2Emilio Berti3Emilio Berti4Angelo Valerio Marzano5Angelo Valerio Marzano6Dermatology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, ItalyDepartment of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, ItalyDermatology Unit, ASST Santi Paolo e Carlo, Milan, ItalyDermatology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, ItalyDepartment of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, ItalyDermatology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, ItalyDepartment of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, ItalyPregnancy may induce the onset or exacerbation of autoimmune bullous diseases such as pemphigus or pemphigoid gestationis. A shift toward T helper (Th) 2 immune response and the influence of hormonal changes have been evoked as possible triggering factors. Therapeutic management of this setting of patients may represent a challenge, mainly due to safety concerns of some immunosuppressive drugs during pregnancy and lactation. In this narrative review, we provided a comprehensive overview of the therapeutic management of autoimmune bullous diseases in pregnant and breastfeeding women, focusing on pemphigus and pemphigoid gestationis.https://www.frontiersin.org/article/10.3389/fphar.2020.583354/fullautoimmune bullous diseasespemphiguspregnancylactationmanagementtreatment |
| spellingShingle | Giovanni Genovese Giovanni Genovese Federica Derlino Emilio Berti Emilio Berti Angelo Valerio Marzano Angelo Valerio Marzano Treatment of Autoimmune Bullous Diseases During Pregnancy and Lactation: A Review Focusing on Pemphigus and Pemphigoid Gestationis Frontiers in Pharmacology autoimmune bullous diseases pemphigus pregnancy lactation management treatment |
| title | Treatment of Autoimmune Bullous Diseases During Pregnancy and Lactation: A Review Focusing on Pemphigus and Pemphigoid Gestationis |
| title_full | Treatment of Autoimmune Bullous Diseases During Pregnancy and Lactation: A Review Focusing on Pemphigus and Pemphigoid Gestationis |
| title_fullStr | Treatment of Autoimmune Bullous Diseases During Pregnancy and Lactation: A Review Focusing on Pemphigus and Pemphigoid Gestationis |
| title_full_unstemmed | Treatment of Autoimmune Bullous Diseases During Pregnancy and Lactation: A Review Focusing on Pemphigus and Pemphigoid Gestationis |
| title_short | Treatment of Autoimmune Bullous Diseases During Pregnancy and Lactation: A Review Focusing on Pemphigus and Pemphigoid Gestationis |
| title_sort | treatment of autoimmune bullous diseases during pregnancy and lactation a review focusing on pemphigus and pemphigoid gestationis |
| topic | autoimmune bullous diseases pemphigus pregnancy lactation management treatment |
| url | https://www.frontiersin.org/article/10.3389/fphar.2020.583354/full |
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