Focused Ultrasound-Induced Cavitation Sensitizes Cancer Cells to Radiation Therapy and Hyperthermia
Focused ultrasound (FUS) has become an important non-invasive therapy for solid tumor ablation via thermal effects. The cavitation effect induced by FUS is thereby avoided but applied for lithotripsy, support drug delivery and the induction of blood vessel destruction for cancer therapy. In this stu...
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| Format: | Article |
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MDPI AG
2020-12-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/9/12/2595 |
| _version_ | 1827700815999008768 |
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| author | Shaonan Hu Xinrui Zhang Michael Unger Ina Patties Andreas Melzer Lisa Landgraf |
| author_facet | Shaonan Hu Xinrui Zhang Michael Unger Ina Patties Andreas Melzer Lisa Landgraf |
| author_sort | Shaonan Hu |
| collection | DOAJ |
| description | Focused ultrasound (FUS) has become an important non-invasive therapy for solid tumor ablation via thermal effects. The cavitation effect induced by FUS is thereby avoided but applied for lithotripsy, support drug delivery and the induction of blood vessel destruction for cancer therapy. In this study, head and neck cancer (FaDu), glioblastoma (T98G), and prostate cancer (PC-3) cells were exposed to FUS by using an in vitro FUS system followed by single-dose X-ray radiation therapy (RT) or water bath hyperthermia (HT). Sensitization effects of short FUS shots with cavitation (FUS-Cav) or without cavitation (FUS) to RT or HT (45 °C, 30 min) were evaluated. FUS-Cav significantly increases the sensitivity of cancer cells to RT and HT by reducing long-term clonogenic survival, short-term cell metabolic activity, cell invasion, and induction of sonoporation. Our results demonstrated that short FUS treatment with cavitation has good potential to sensitize cancer cells to RT and HT non-invasively. |
| first_indexed | 2024-03-10T14:20:13Z |
| format | Article |
| id | doaj.art-33162d8cc027473da9d7cb2902b5da67 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T14:20:13Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-33162d8cc027473da9d7cb2902b5da672023-11-20T23:24:29ZengMDPI AGCells2073-44092020-12-01912259510.3390/cells9122595Focused Ultrasound-Induced Cavitation Sensitizes Cancer Cells to Radiation Therapy and HyperthermiaShaonan Hu0Xinrui Zhang1Michael Unger2Ina Patties3Andreas Melzer4Lisa Landgraf5Innovation Center Computer Assisted Surgery (ICCAS), University of Leipzig, 04103 Leipzig, GermanyInnovation Center Computer Assisted Surgery (ICCAS), University of Leipzig, 04103 Leipzig, GermanyInnovation Center Computer Assisted Surgery (ICCAS), University of Leipzig, 04103 Leipzig, GermanyInnovation Center Computer Assisted Surgery (ICCAS), University of Leipzig, 04103 Leipzig, GermanyInnovation Center Computer Assisted Surgery (ICCAS), University of Leipzig, 04103 Leipzig, GermanyInnovation Center Computer Assisted Surgery (ICCAS), University of Leipzig, 04103 Leipzig, GermanyFocused ultrasound (FUS) has become an important non-invasive therapy for solid tumor ablation via thermal effects. The cavitation effect induced by FUS is thereby avoided but applied for lithotripsy, support drug delivery and the induction of blood vessel destruction for cancer therapy. In this study, head and neck cancer (FaDu), glioblastoma (T98G), and prostate cancer (PC-3) cells were exposed to FUS by using an in vitro FUS system followed by single-dose X-ray radiation therapy (RT) or water bath hyperthermia (HT). Sensitization effects of short FUS shots with cavitation (FUS-Cav) or without cavitation (FUS) to RT or HT (45 °C, 30 min) were evaluated. FUS-Cav significantly increases the sensitivity of cancer cells to RT and HT by reducing long-term clonogenic survival, short-term cell metabolic activity, cell invasion, and induction of sonoporation. Our results demonstrated that short FUS treatment with cavitation has good potential to sensitize cancer cells to RT and HT non-invasively.https://www.mdpi.com/2073-4409/9/12/2595focused ultrasoundcavitationradiation therapyhyperthermiasensitization |
| spellingShingle | Shaonan Hu Xinrui Zhang Michael Unger Ina Patties Andreas Melzer Lisa Landgraf Focused Ultrasound-Induced Cavitation Sensitizes Cancer Cells to Radiation Therapy and Hyperthermia Cells focused ultrasound cavitation radiation therapy hyperthermia sensitization |
| title | Focused Ultrasound-Induced Cavitation Sensitizes Cancer Cells to Radiation Therapy and Hyperthermia |
| title_full | Focused Ultrasound-Induced Cavitation Sensitizes Cancer Cells to Radiation Therapy and Hyperthermia |
| title_fullStr | Focused Ultrasound-Induced Cavitation Sensitizes Cancer Cells to Radiation Therapy and Hyperthermia |
| title_full_unstemmed | Focused Ultrasound-Induced Cavitation Sensitizes Cancer Cells to Radiation Therapy and Hyperthermia |
| title_short | Focused Ultrasound-Induced Cavitation Sensitizes Cancer Cells to Radiation Therapy and Hyperthermia |
| title_sort | focused ultrasound induced cavitation sensitizes cancer cells to radiation therapy and hyperthermia |
| topic | focused ultrasound cavitation radiation therapy hyperthermia sensitization |
| url | https://www.mdpi.com/2073-4409/9/12/2595 |
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