| Summary: | The features of development of valvular vehicle of aorta and pulmonary trunk in 32 hearts of embryos and early and late fetuses were studied using the macro-microscopic and histological methods. Our data showed that the cusps of valves contain the loosely scattered mesenchyme cells on the onset of development, so they have the same composition as endocardial cushions of the atrio-ventricular canal and endocardial ridges of conotruncus. The primary valves are represented with mesenhymal outgrowths to the cavity of a vessel, the base of which is considerably wide and stars from the vessel wall, and free edge is thin and faces to vessel lumen. On the early stages of development in the place where the onset of primary cusps development takes place, the wall of large vessels of the heart contains the substantial layer of cardiomyocites, and there is a slight amount of cardiogelly between mesenhyma of the leaflets and vessel wall. On the next stages of the embryogenesis the number and density of collagen fibers increase in the leaflets.
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