Genomic breeding value estimation using nonparametric additive regression models
<p>Abstract</p> <p>Genomic selection refers to the use of genomewide dense markers for breeding value estimation and subsequently for selection. The main challenge of genomic breeding value estimation is the estimation of many effects from a limited number of observations. Bayesian...
| Main Authors: | , , |
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| Format: | Article |
| Language: | deu |
| Published: |
BMC
2009-01-01
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| Series: | Genetics Selection Evolution |
| Online Access: | http://www.gsejournal.org/content/41/1/20 |
| _version_ | 1818779100105408512 |
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| author | Solberg Trygve Bennewitz Jörn Meuwissen Theo |
| author_facet | Solberg Trygve Bennewitz Jörn Meuwissen Theo |
| author_sort | Solberg Trygve |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Genomic selection refers to the use of genomewide dense markers for breeding value estimation and subsequently for selection. The main challenge of genomic breeding value estimation is the estimation of many effects from a limited number of observations. Bayesian methods have been proposed to successfully cope with these challenges. As an alternative class of models, non- and semiparametric models were recently introduced. The present study investigated the ability of nonparametric additive regression models to predict genomic breeding values. The genotypes were modelled for each marker or pair of flanking markers (<it>i.e</it>. the predictors) separately. The nonparametric functions for the predictors were estimated simultaneously using additive model theory, applying a binomial kernel. The optimal degree of smoothing was determined by bootstrapping. A mutation-drift-balance simulation was carried out. The breeding values of the last generation (genotyped) was predicted using data from the next last generation (genotyped and phenotyped). The results show moderate to high accuracies of the predicted breeding values. A determination of predictor specific degree of smoothing increased the accuracy.</p> |
| first_indexed | 2024-12-18T11:55:14Z |
| format | Article |
| id | doaj.art-3318c4bf5aab41ab8cc17d6d5db7f514 |
| institution | Directory Open Access Journal |
| issn | 0999-193X 1297-9686 |
| language | deu |
| last_indexed | 2024-12-18T11:55:14Z |
| publishDate | 2009-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Genetics Selection Evolution |
| spelling | doaj.art-3318c4bf5aab41ab8cc17d6d5db7f5142022-12-21T21:09:05ZdeuBMCGenetics Selection Evolution0999-193X1297-96862009-01-014112010.1186/1297-9686-41-20Genomic breeding value estimation using nonparametric additive regression modelsSolberg TrygveBennewitz JörnMeuwissen Theo<p>Abstract</p> <p>Genomic selection refers to the use of genomewide dense markers for breeding value estimation and subsequently for selection. The main challenge of genomic breeding value estimation is the estimation of many effects from a limited number of observations. Bayesian methods have been proposed to successfully cope with these challenges. As an alternative class of models, non- and semiparametric models were recently introduced. The present study investigated the ability of nonparametric additive regression models to predict genomic breeding values. The genotypes were modelled for each marker or pair of flanking markers (<it>i.e</it>. the predictors) separately. The nonparametric functions for the predictors were estimated simultaneously using additive model theory, applying a binomial kernel. The optimal degree of smoothing was determined by bootstrapping. A mutation-drift-balance simulation was carried out. The breeding values of the last generation (genotyped) was predicted using data from the next last generation (genotyped and phenotyped). The results show moderate to high accuracies of the predicted breeding values. A determination of predictor specific degree of smoothing increased the accuracy.</p>http://www.gsejournal.org/content/41/1/20 |
| spellingShingle | Solberg Trygve Bennewitz Jörn Meuwissen Theo Genomic breeding value estimation using nonparametric additive regression models Genetics Selection Evolution |
| title | Genomic breeding value estimation using nonparametric additive regression models |
| title_full | Genomic breeding value estimation using nonparametric additive regression models |
| title_fullStr | Genomic breeding value estimation using nonparametric additive regression models |
| title_full_unstemmed | Genomic breeding value estimation using nonparametric additive regression models |
| title_short | Genomic breeding value estimation using nonparametric additive regression models |
| title_sort | genomic breeding value estimation using nonparametric additive regression models |
| url | http://www.gsejournal.org/content/41/1/20 |
| work_keys_str_mv | AT solbergtrygve genomicbreedingvalueestimationusingnonparametricadditiveregressionmodels AT bennewitzjorn genomicbreedingvalueestimationusingnonparametricadditiveregressionmodels AT meuwissentheo genomicbreedingvalueestimationusingnonparametricadditiveregressionmodels |