Risky working conditions and chronic kidney disease
Abstract Background Individuals in the workplace are exposed to various environments, tasks, and schedules. Previous studies have indicated a link between occupational exposures and an increased risk of chronic kidney disease (CKD). However, the social conditions of the work environment may also be...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-11-01
|
| Series: | Journal of Occupational Medicine and Toxicology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12995-023-00393-3 |
| _version_ | 1797555585431896064 |
|---|---|
| author | Rui Lan Yao Qin Xiangjun Chen Jinbo Hu Wenjin Luo Yan Shen Xue Li Lina Mao Hanwen Ye Zhihong Wang |
| author_facet | Rui Lan Yao Qin Xiangjun Chen Jinbo Hu Wenjin Luo Yan Shen Xue Li Lina Mao Hanwen Ye Zhihong Wang |
| author_sort | Rui Lan |
| collection | DOAJ |
| description | Abstract Background Individuals in the workplace are exposed to various environments, tasks, and schedules. Previous studies have indicated a link between occupational exposures and an increased risk of chronic kidney disease (CKD). However, the social conditions of the work environment may also be a crucial contributing factor to CKD. Furthermore, individuals may encounter multiple occupational-related risk factors simultaneously, underscoring the importance of investigating the joint risk of different working conditions on CKD. Methods A prospective analysis of 65,069 UK Biobank participants aged 40 to 69 years without CKD at baseline (2006–2010) was performed. A self-administered questionnaire assessed working conditions and a working conditions risk score were developed. Participants who answered “sometimes” or “often” exposure to occupational heat or occupational secondhand cigarette smoke; involved in shift work or heavy workloads (“usually” or “always”), were grouped as high-risk working conditions. Each working condition was scored as 1 if grouped as high-risk, and 0 if not. The working conditions risk score was equal to the sum of these four working conditions. Cox proportional hazard regression models were used to estimate the associations between working conditions and CKD incidence. Results The mean follow-up time was 6.7 years. After adjusting for demographic, lifestyle, and working time factors, the hazard ratios for the development of CKD for heavy workloads, shift work, occupational secondhand cigarette smoke exposure, and occupational heat exposure were 1.24 (95%CI = 1.03, 1.51), 1.33 (95%CI = 1.10, 1.62), 1.13 (95%CI = 1.01, 1.26), 1.11 (95%CI = 0.99, 1.24), respectively. The risk of CKD was found to be significantly associated with an increasing working conditions risk score. Individuals with a working conditions risk score of 4 had an 88.0% (95% CI = 1.05, 3.35) higher risk of developing CKD when compared to those with a working conditions risk score of 0. Conclusions Adverse working conditions, particularly when considered in combination, can significantly elevate the risk of chronic kidney disease (CKD). These results provide a reference for implementing measures to prevent CKD. |
| first_indexed | 2024-03-10T16:49:34Z |
| format | Article |
| id | doaj.art-331b7e9e52484be4a65623c9ab0532c1 |
| institution | Directory Open Access Journal |
| issn | 1745-6673 |
| language | English |
| last_indexed | 2024-03-10T16:49:34Z |
| publishDate | 2023-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Occupational Medicine and Toxicology |
| spelling | doaj.art-331b7e9e52484be4a65623c9ab0532c12023-11-20T11:21:03ZengBMCJournal of Occupational Medicine and Toxicology1745-66732023-11-011811810.1186/s12995-023-00393-3Risky working conditions and chronic kidney diseaseRui Lan0Yao Qin1Xiangjun Chen2Jinbo Hu3Wenjin Luo4Yan Shen5Xue Li6Lina Mao7Hanwen Ye8Zhihong Wang9Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Endocrinology, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Endocrinology, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Endocrinology, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Endocrinology, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Endocrinology, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Endocrinology, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Endocrinology, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Endocrinology, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Endocrinology, The First Affiliated Hospital of Chongqing Medical UniversityAbstract Background Individuals in the workplace are exposed to various environments, tasks, and schedules. Previous studies have indicated a link between occupational exposures and an increased risk of chronic kidney disease (CKD). However, the social conditions of the work environment may also be a crucial contributing factor to CKD. Furthermore, individuals may encounter multiple occupational-related risk factors simultaneously, underscoring the importance of investigating the joint risk of different working conditions on CKD. Methods A prospective analysis of 65,069 UK Biobank participants aged 40 to 69 years without CKD at baseline (2006–2010) was performed. A self-administered questionnaire assessed working conditions and a working conditions risk score were developed. Participants who answered “sometimes” or “often” exposure to occupational heat or occupational secondhand cigarette smoke; involved in shift work or heavy workloads (“usually” or “always”), were grouped as high-risk working conditions. Each working condition was scored as 1 if grouped as high-risk, and 0 if not. The working conditions risk score was equal to the sum of these four working conditions. Cox proportional hazard regression models were used to estimate the associations between working conditions and CKD incidence. Results The mean follow-up time was 6.7 years. After adjusting for demographic, lifestyle, and working time factors, the hazard ratios for the development of CKD for heavy workloads, shift work, occupational secondhand cigarette smoke exposure, and occupational heat exposure were 1.24 (95%CI = 1.03, 1.51), 1.33 (95%CI = 1.10, 1.62), 1.13 (95%CI = 1.01, 1.26), 1.11 (95%CI = 0.99, 1.24), respectively. The risk of CKD was found to be significantly associated with an increasing working conditions risk score. Individuals with a working conditions risk score of 4 had an 88.0% (95% CI = 1.05, 3.35) higher risk of developing CKD when compared to those with a working conditions risk score of 0. Conclusions Adverse working conditions, particularly when considered in combination, can significantly elevate the risk of chronic kidney disease (CKD). These results provide a reference for implementing measures to prevent CKD.https://doi.org/10.1186/s12995-023-00393-3OccupationalChronic kidney diseaseWork environments |
| spellingShingle | Rui Lan Yao Qin Xiangjun Chen Jinbo Hu Wenjin Luo Yan Shen Xue Li Lina Mao Hanwen Ye Zhihong Wang Risky working conditions and chronic kidney disease Journal of Occupational Medicine and Toxicology Occupational Chronic kidney disease Work environments |
| title | Risky working conditions and chronic kidney disease |
| title_full | Risky working conditions and chronic kidney disease |
| title_fullStr | Risky working conditions and chronic kidney disease |
| title_full_unstemmed | Risky working conditions and chronic kidney disease |
| title_short | Risky working conditions and chronic kidney disease |
| title_sort | risky working conditions and chronic kidney disease |
| topic | Occupational Chronic kidney disease Work environments |
| url | https://doi.org/10.1186/s12995-023-00393-3 |
| work_keys_str_mv | AT ruilan riskyworkingconditionsandchronickidneydisease AT yaoqin riskyworkingconditionsandchronickidneydisease AT xiangjunchen riskyworkingconditionsandchronickidneydisease AT jinbohu riskyworkingconditionsandchronickidneydisease AT wenjinluo riskyworkingconditionsandchronickidneydisease AT yanshen riskyworkingconditionsandchronickidneydisease AT xueli riskyworkingconditionsandchronickidneydisease AT linamao riskyworkingconditionsandchronickidneydisease AT hanwenye riskyworkingconditionsandchronickidneydisease AT zhihongwang riskyworkingconditionsandchronickidneydisease |