Different approaches to modelling the cost-effectiveness of schistosomiasis control
This paper reviews three different approaches to modelling the cost-effectiveness of schistosomiasis control. Although these approaches vary in their assessment of costs, the major focus of the paper is on the evaluation of effectiveness. The first model presented is a static economic model which as...
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
1998-01-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761998000700010 |
| _version_ | 1797757244628008960 |
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| author | Guyatt Helen |
| author_facet | Guyatt Helen |
| author_sort | Guyatt Helen |
| collection | DOAJ |
| description | This paper reviews three different approaches to modelling the cost-effectiveness of schistosomiasis control. Although these approaches vary in their assessment of costs, the major focus of the paper is on the evaluation of effectiveness. The first model presented is a static economic model which assesses effectiveness in terms of the proportion of cases cured. This model is important in highlighting that the optimal choice of chemotherapy regime depends critically on the level of budget constraint, the unit costs of screening and treatment, the rates of compliance with screening and chemotherapy and the prevalence of infection. The limitations of this approach is that it models the cost-effectiveness of only one cycle of treatment, and effectiveness reflects only the immediate impact of treatment. The second model presented is a prevalence-based dynamic model which links prevalence rates from one year to the next, and assesses effectiveness as the proportion of cases prevented. This model was important as it introduced the concept of measuring the long-term impact of control by using a transmission model which can assess reduction in infection through time, but is limited to assessing the impact only on the prevalence of infection. The third approach presented is a theoretical framework which describes the dynamic relationships between infection and morbidity, and which assesses effectiveness in terms of case-years prevented of infection and morbidity. The use of this model in assessing the cost-effectiveness of age-targeted treatment in controlling Schistosoma mansoni is explored in detail, with respect to varying frequencies of treatment and the interaction between drug price and drug efficacy. |
| first_indexed | 2024-03-12T18:13:05Z |
| format | Article |
| id | doaj.art-331e2540746a43c08773c15a23e50479 |
| institution | Directory Open Access Journal |
| issn | 0074-0276 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T18:13:05Z |
| publishDate | 1998-01-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-331e2540746a43c08773c15a23e504792023-08-02T09:14:10ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz0074-02761678-80601998-01-0193suppl.17584Different approaches to modelling the cost-effectiveness of schistosomiasis controlGuyatt HelenThis paper reviews three different approaches to modelling the cost-effectiveness of schistosomiasis control. Although these approaches vary in their assessment of costs, the major focus of the paper is on the evaluation of effectiveness. The first model presented is a static economic model which assesses effectiveness in terms of the proportion of cases cured. This model is important in highlighting that the optimal choice of chemotherapy regime depends critically on the level of budget constraint, the unit costs of screening and treatment, the rates of compliance with screening and chemotherapy and the prevalence of infection. The limitations of this approach is that it models the cost-effectiveness of only one cycle of treatment, and effectiveness reflects only the immediate impact of treatment. The second model presented is a prevalence-based dynamic model which links prevalence rates from one year to the next, and assesses effectiveness as the proportion of cases prevented. This model was important as it introduced the concept of measuring the long-term impact of control by using a transmission model which can assess reduction in infection through time, but is limited to assessing the impact only on the prevalence of infection. The third approach presented is a theoretical framework which describes the dynamic relationships between infection and morbidity, and which assesses effectiveness in terms of case-years prevented of infection and morbidity. The use of this model in assessing the cost-effectiveness of age-targeted treatment in controlling Schistosoma mansoni is explored in detail, with respect to varying frequencies of treatment and the interaction between drug price and drug efficacy.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761998000700010schistosomiasismathematical modellingcost-effectiveness analysiscontrolmorbidity |
| spellingShingle | Guyatt Helen Different approaches to modelling the cost-effectiveness of schistosomiasis control Memorias do Instituto Oswaldo Cruz schistosomiasis mathematical modelling cost-effectiveness analysis control morbidity |
| title | Different approaches to modelling the cost-effectiveness of schistosomiasis control |
| title_full | Different approaches to modelling the cost-effectiveness of schistosomiasis control |
| title_fullStr | Different approaches to modelling the cost-effectiveness of schistosomiasis control |
| title_full_unstemmed | Different approaches to modelling the cost-effectiveness of schistosomiasis control |
| title_short | Different approaches to modelling the cost-effectiveness of schistosomiasis control |
| title_sort | different approaches to modelling the cost effectiveness of schistosomiasis control |
| topic | schistosomiasis mathematical modelling cost-effectiveness analysis control morbidity |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761998000700010 |
| work_keys_str_mv | AT guyatthelen differentapproachestomodellingthecosteffectivenessofschistosomiasiscontrol |