Solubility of Sulfamethazine in the Binary Mixture of Acetonitrile + Methanol from 278.15 to 318.15 K: Measurement, Dissolution Thermodynamics, Preferential Solvation, and Correlation
Solubility of sulfamethazine (SMT) in acetonitrile (MeCN) + methanol (MeOH) cosolvents was determined at nine temperatures between 278.15 and 318.15 K. From the solubility data expressed in molar fraction, the thermodynamic functions of solution, transfer and mixing were calculated using the Gibbs a...
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MDPI AG
2021-12-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/24/7588 |
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| author | Claudia Patricia Ortiz Rossember Edén Cardenas-Torres Fleming Martínez Daniel Ricardo Delgado |
| author_facet | Claudia Patricia Ortiz Rossember Edén Cardenas-Torres Fleming Martínez Daniel Ricardo Delgado |
| author_sort | Claudia Patricia Ortiz |
| collection | DOAJ |
| description | Solubility of sulfamethazine (SMT) in acetonitrile (MeCN) + methanol (MeOH) cosolvents was determined at nine temperatures between 278.15 and 318.15 K. From the solubility data expressed in molar fraction, the thermodynamic functions of solution, transfer and mixing were calculated using the Gibbs and van ’t Hoff equations; on the other hand, the solubility data were modeled according to the Wilson models and NRTL. The solubility of SMT is thermo-dependent and is influenced by the solubility parameter of the cosolvent mixtures. In this case, the maximum solubility was achieved in the cosolvent mixture <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><msub><mi>w</mi><mrow><mn>0.40</mn></mrow></msub></semantics></math></inline-formula> at 318.15 K and the minimum in pure MeOH at 278.15 K. According to the thermodynamic functions, the SMT solution process is endothermic in addition to being favored by the entropic factor, and as for the preferential solvation parameter, SMT tends to be preferentially solvated by MeOH in all cosolvent systems; however, <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi>δ</mi><msub><mi>x</mi><mrow><mn>3</mn><mo>,</mo><mn>1</mn></mrow></msub><mo><</mo><mn>0.01</mn></mrow></semantics></math></inline-formula>, so the results are not conclusive. Finally, according to mean relative deviations (MRD%), the two models could be very useful tools for calculating the solubility of SMT in cosolvent mixtures and temperatures different from those reported in this research. |
| first_indexed | 2024-03-10T03:28:05Z |
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| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T03:28:05Z |
| publishDate | 2021-12-01 |
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| series | Molecules |
| spelling | doaj.art-331e5783667c463f8c15c3d686c2d5f02023-11-23T09:46:23ZengMDPI AGMolecules1420-30492021-12-012624758810.3390/molecules26247588Solubility of Sulfamethazine in the Binary Mixture of Acetonitrile + Methanol from 278.15 to 318.15 K: Measurement, Dissolution Thermodynamics, Preferential Solvation, and CorrelationClaudia Patricia Ortiz0Rossember Edén Cardenas-Torres1Fleming Martínez2Daniel Ricardo Delgado3Programa de Administración en Seguridad y Salud en el Trabajo, Grupo de Investigación en Seguridad y Salud en el Trabajo, Corporación Universitaria Minuto de Dios-UNIMINUTO, Neiva 410001, Huila, ColombiaGrupo de Fisicoquímica y Análisis Matemático, Facultad de Ciencias y Humanidades, Fundación Universidad de América, Avenida Circunvalar No. 20-53, Bogotá 110321, Distrito Capital, ColombiaGrupo de Investigaciones Farmacéutico-Fisicoquímicas, Departamento de Farmacia, Facultad de Ciencias, Universidad Nacional de Colombia, Sede Bogotá, Carrera 30 No. 45-03, Bogotá 111321, Distrito Capital, ColombiaPrograma de Ingeniería Civil, Grupo de Investigación de Ingenierías UCC-Neiva, Facultad de Ingeniería, Universidad Cooperativa de Colombia, Sede Neiva, Calle 11 No. 1-51, Neiva 410010, Huila, ColombiaSolubility of sulfamethazine (SMT) in acetonitrile (MeCN) + methanol (MeOH) cosolvents was determined at nine temperatures between 278.15 and 318.15 K. From the solubility data expressed in molar fraction, the thermodynamic functions of solution, transfer and mixing were calculated using the Gibbs and van ’t Hoff equations; on the other hand, the solubility data were modeled according to the Wilson models and NRTL. The solubility of SMT is thermo-dependent and is influenced by the solubility parameter of the cosolvent mixtures. In this case, the maximum solubility was achieved in the cosolvent mixture <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><msub><mi>w</mi><mrow><mn>0.40</mn></mrow></msub></semantics></math></inline-formula> at 318.15 K and the minimum in pure MeOH at 278.15 K. According to the thermodynamic functions, the SMT solution process is endothermic in addition to being favored by the entropic factor, and as for the preferential solvation parameter, SMT tends to be preferentially solvated by MeOH in all cosolvent systems; however, <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi>δ</mi><msub><mi>x</mi><mrow><mn>3</mn><mo>,</mo><mn>1</mn></mrow></msub><mo><</mo><mn>0.01</mn></mrow></semantics></math></inline-formula>, so the results are not conclusive. Finally, according to mean relative deviations (MRD%), the two models could be very useful tools for calculating the solubility of SMT in cosolvent mixtures and temperatures different from those reported in this research.https://www.mdpi.com/1420-3049/26/24/7588solubilitysulfamethazinesolution thermodynamicspreferential solvationWilson modelNRTL model |
| spellingShingle | Claudia Patricia Ortiz Rossember Edén Cardenas-Torres Fleming Martínez Daniel Ricardo Delgado Solubility of Sulfamethazine in the Binary Mixture of Acetonitrile + Methanol from 278.15 to 318.15 K: Measurement, Dissolution Thermodynamics, Preferential Solvation, and Correlation Molecules solubility sulfamethazine solution thermodynamics preferential solvation Wilson model NRTL model |
| title | Solubility of Sulfamethazine in the Binary Mixture of Acetonitrile + Methanol from 278.15 to 318.15 K: Measurement, Dissolution Thermodynamics, Preferential Solvation, and Correlation |
| title_full | Solubility of Sulfamethazine in the Binary Mixture of Acetonitrile + Methanol from 278.15 to 318.15 K: Measurement, Dissolution Thermodynamics, Preferential Solvation, and Correlation |
| title_fullStr | Solubility of Sulfamethazine in the Binary Mixture of Acetonitrile + Methanol from 278.15 to 318.15 K: Measurement, Dissolution Thermodynamics, Preferential Solvation, and Correlation |
| title_full_unstemmed | Solubility of Sulfamethazine in the Binary Mixture of Acetonitrile + Methanol from 278.15 to 318.15 K: Measurement, Dissolution Thermodynamics, Preferential Solvation, and Correlation |
| title_short | Solubility of Sulfamethazine in the Binary Mixture of Acetonitrile + Methanol from 278.15 to 318.15 K: Measurement, Dissolution Thermodynamics, Preferential Solvation, and Correlation |
| title_sort | solubility of sulfamethazine in the binary mixture of acetonitrile methanol from 278 15 to 318 15 k measurement dissolution thermodynamics preferential solvation and correlation |
| topic | solubility sulfamethazine solution thermodynamics preferential solvation Wilson model NRTL model |
| url | https://www.mdpi.com/1420-3049/26/24/7588 |
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