Relationship between spinal structural damage on radiography and bone fragility on CT in ankylosing spondylitis patients
Abstract To evaluate whether the risk of bone fragility on computed tomography (CT) (scanographic bone attenuation coefficient of the first lumbar vertebra (SBAC-L1)) is associated with the severity of spine structural involvement (mSASSS) in patients with ankylosing spondylitis (AS). This retrospec...
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| Format: | Article |
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Nature Portfolio
2021-04-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-88838-9 |
| _version_ | 1818736175478734848 |
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| author | Marine Fauny Frank Verhoeven Edem Allado Eliane Albuisson Astrid Pinzano Caroline Morizot Isabelle Chary-Valckenaere Damien Loeuille |
| author_facet | Marine Fauny Frank Verhoeven Edem Allado Eliane Albuisson Astrid Pinzano Caroline Morizot Isabelle Chary-Valckenaere Damien Loeuille |
| author_sort | Marine Fauny |
| collection | DOAJ |
| description | Abstract To evaluate whether the risk of bone fragility on computed tomography (CT) (scanographic bone attenuation coefficient of the first lumbar vertebra (SBAC-L1)) is associated with the severity of spine structural involvement (mSASSS) in patients with ankylosing spondylitis (AS). This retrospective study included AS patients, followed from 2009 to 2017, who fulfilled the New York criteria and who underwent thoraco-abdomino-pelvic CT and radiography (spine, pelvis). The structural involvement was retained for mSASSS ≥ 2. The SBAC-L1 was measured in Hounsfield units (HU). A SBAC-L1 ≤ 145 HU was used to define patients at risk of vertebral fracture (VF). A total of 73 AS patients were included (mean age: 60.3 (± 10.7) years, 8 women (11%), mean disease duration: 24.6 years (± 13.9)). Sixty patients (82.2%) had a mSASSS ≥ 2 (mean score 20.7 (± 21.2)). The mean SBAC-L1 was 141.1 HU (± 45), 138.1 HU (± 44.8) and 154.8 HU (± 44.9) in the total, mSASSS ≥ 2 and mSASSS < 2 populations, respectively. Patients with bone bridges had lower SBAC-L1 than mSASSS ≥ 2 patients without ankylosis (p = 0.02) and more often SBAC-L1 ≤ 145 HU (73% vs 41.9%, p = 0.006). A SBAC-L1 ≤ 145 HU was not associated with structural spine involvement, but patients with bone bridges had significantly decreased SBAC-L1 and an increased probability of being under the fracture threshold. |
| first_indexed | 2024-12-18T00:32:58Z |
| format | Article |
| id | doaj.art-331f0ad7ae804bae9fdeec791037b57c |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-18T00:32:58Z |
| publishDate | 2021-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-331f0ad7ae804bae9fdeec791037b57c2022-12-21T21:27:06ZengNature PortfolioScientific Reports2045-23222021-04-011111910.1038/s41598-021-88838-9Relationship between spinal structural damage on radiography and bone fragility on CT in ankylosing spondylitis patientsMarine Fauny0Frank Verhoeven1Edem Allado2Eliane Albuisson3Astrid Pinzano4Caroline Morizot5Isabelle Chary-Valckenaere6Damien Loeuille7Department of Rheumatology, Hôpitaux de Brabois, Nancy University HospitalDepartment of Rheumatology, Besançon University HospitalDepartment of Rheumatology, Hôpitaux de Brabois, Nancy University HospitalFaculté de Medecine, InSciDens, Université de LorraineIngénierie Moléculaire et Physiopathologie Articulaire (IMoPA), UMR 7365 CNRS – University of LorraineDepartment of Rheumatology, Hôpitaux de Brabois, Nancy University HospitalDepartment of Rheumatology, Hôpitaux de Brabois, Nancy University HospitalDepartment of Rheumatology, Hôpitaux de Brabois, Nancy University HospitalAbstract To evaluate whether the risk of bone fragility on computed tomography (CT) (scanographic bone attenuation coefficient of the first lumbar vertebra (SBAC-L1)) is associated with the severity of spine structural involvement (mSASSS) in patients with ankylosing spondylitis (AS). This retrospective study included AS patients, followed from 2009 to 2017, who fulfilled the New York criteria and who underwent thoraco-abdomino-pelvic CT and radiography (spine, pelvis). The structural involvement was retained for mSASSS ≥ 2. The SBAC-L1 was measured in Hounsfield units (HU). A SBAC-L1 ≤ 145 HU was used to define patients at risk of vertebral fracture (VF). A total of 73 AS patients were included (mean age: 60.3 (± 10.7) years, 8 women (11%), mean disease duration: 24.6 years (± 13.9)). Sixty patients (82.2%) had a mSASSS ≥ 2 (mean score 20.7 (± 21.2)). The mean SBAC-L1 was 141.1 HU (± 45), 138.1 HU (± 44.8) and 154.8 HU (± 44.9) in the total, mSASSS ≥ 2 and mSASSS < 2 populations, respectively. Patients with bone bridges had lower SBAC-L1 than mSASSS ≥ 2 patients without ankylosis (p = 0.02) and more often SBAC-L1 ≤ 145 HU (73% vs 41.9%, p = 0.006). A SBAC-L1 ≤ 145 HU was not associated with structural spine involvement, but patients with bone bridges had significantly decreased SBAC-L1 and an increased probability of being under the fracture threshold.https://doi.org/10.1038/s41598-021-88838-9 |
| spellingShingle | Marine Fauny Frank Verhoeven Edem Allado Eliane Albuisson Astrid Pinzano Caroline Morizot Isabelle Chary-Valckenaere Damien Loeuille Relationship between spinal structural damage on radiography and bone fragility on CT in ankylosing spondylitis patients Scientific Reports |
| title | Relationship between spinal structural damage on radiography and bone fragility on CT in ankylosing spondylitis patients |
| title_full | Relationship between spinal structural damage on radiography and bone fragility on CT in ankylosing spondylitis patients |
| title_fullStr | Relationship between spinal structural damage on radiography and bone fragility on CT in ankylosing spondylitis patients |
| title_full_unstemmed | Relationship between spinal structural damage on radiography and bone fragility on CT in ankylosing spondylitis patients |
| title_short | Relationship between spinal structural damage on radiography and bone fragility on CT in ankylosing spondylitis patients |
| title_sort | relationship between spinal structural damage on radiography and bone fragility on ct in ankylosing spondylitis patients |
| url | https://doi.org/10.1038/s41598-021-88838-9 |
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