The cGAS-STING Pathway in Hematopoiesis and Its Physiopathological Significance
Cytosolic DNA sensing is a fundamental mechanism by which organisms handle various stresses, including infection and genotoxicity. The hematopoietic system is sensitive to stresses, and hematopoietic changes are often rapid and the first response to stresses. Based on the transcriptome database, cyt...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-11-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2020.573915/full |
| _version_ | 1818648910435975168 |
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| author | Weinian Liao Changhong Du Junping Wang |
| author_facet | Weinian Liao Changhong Du Junping Wang |
| author_sort | Weinian Liao |
| collection | DOAJ |
| description | Cytosolic DNA sensing is a fundamental mechanism by which organisms handle various stresses, including infection and genotoxicity. The hematopoietic system is sensitive to stresses, and hematopoietic changes are often rapid and the first response to stresses. Based on the transcriptome database, cytosolic DNA sensing pathways are widely expressed in the hematopoietic system, and components of these pathways may be expressed at even higher levels in hematopoietic stem and progenitor cells (HSPCs) than in their certain progeny immune cells. Recent studies have described a previously unrecognized role for cytosolic DNA sensing pathways in the regulation of hematopoiesis under both homeostatic and stress conditions. In particular, the recently discovered cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway is a critical modulator of hematopoiesis. Perturbation of the cGAS-STING pathway in HSPCs may be involved in the pathogenesis of hematopoietic disorders, autoimmune diseases, and inflammation-related diseases and may be candidate therapeutic targets. In this review, we focus on the recent findings of the cGAS-STING pathway in the regulation of hematopoiesis, and its physiopathological significance including its implications in diseases and therapeutic potential. |
| first_indexed | 2024-12-17T01:25:56Z |
| format | Article |
| id | doaj.art-331f8964fe0a4e0aa35db2da9e7635ea |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-17T01:25:56Z |
| publishDate | 2020-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-331f8964fe0a4e0aa35db2da9e7635ea2022-12-21T22:08:41ZengFrontiers Media S.A.Frontiers in Immunology1664-32242020-11-011110.3389/fimmu.2020.573915573915The cGAS-STING Pathway in Hematopoiesis and Its Physiopathological SignificanceWeinian LiaoChanghong DuJunping WangCytosolic DNA sensing is a fundamental mechanism by which organisms handle various stresses, including infection and genotoxicity. The hematopoietic system is sensitive to stresses, and hematopoietic changes are often rapid and the first response to stresses. Based on the transcriptome database, cytosolic DNA sensing pathways are widely expressed in the hematopoietic system, and components of these pathways may be expressed at even higher levels in hematopoietic stem and progenitor cells (HSPCs) than in their certain progeny immune cells. Recent studies have described a previously unrecognized role for cytosolic DNA sensing pathways in the regulation of hematopoiesis under both homeostatic and stress conditions. In particular, the recently discovered cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway is a critical modulator of hematopoiesis. Perturbation of the cGAS-STING pathway in HSPCs may be involved in the pathogenesis of hematopoietic disorders, autoimmune diseases, and inflammation-related diseases and may be candidate therapeutic targets. In this review, we focus on the recent findings of the cGAS-STING pathway in the regulation of hematopoiesis, and its physiopathological significance including its implications in diseases and therapeutic potential.https://www.frontiersin.org/articles/10.3389/fimmu.2020.573915/fullcGAS-STING pathwayHematopoiesisHematopoietic stem and progenitor cellsCytosolic DNA sensingInnate Immunity and inflammation |
| spellingShingle | Weinian Liao Changhong Du Junping Wang The cGAS-STING Pathway in Hematopoiesis and Its Physiopathological Significance Frontiers in Immunology cGAS-STING pathway Hematopoiesis Hematopoietic stem and progenitor cells Cytosolic DNA sensing Innate Immunity and inflammation |
| title | The cGAS-STING Pathway in Hematopoiesis and Its Physiopathological Significance |
| title_full | The cGAS-STING Pathway in Hematopoiesis and Its Physiopathological Significance |
| title_fullStr | The cGAS-STING Pathway in Hematopoiesis and Its Physiopathological Significance |
| title_full_unstemmed | The cGAS-STING Pathway in Hematopoiesis and Its Physiopathological Significance |
| title_short | The cGAS-STING Pathway in Hematopoiesis and Its Physiopathological Significance |
| title_sort | cgas sting pathway in hematopoiesis and its physiopathological significance |
| topic | cGAS-STING pathway Hematopoiesis Hematopoietic stem and progenitor cells Cytosolic DNA sensing Innate Immunity and inflammation |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2020.573915/full |
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