Systematic design of pulse dosing to eradicate persister bacteria.

A small fraction of infectious bacteria use persistence as a strategy to survive exposure to antibiotics. Periodic pulse dosing of antibiotics has long been considered a potentially effective strategy towards eradication of persisters. Recent studies have demonstrated through in vitro experiments th...

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Bibliographic Details
Main Authors: Garima Singh, Mehmet A Orman, Jacinta C Conrad, Michael Nikolaou
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-01-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.1010243