Could Metrnl be a New Biomarker to Predict the Development of Macrophage Activation Syndrome in COVID-19 Patients?
Introduction: Failure to maintain the inflammatory and anti-inflammatory balance during COVID-19 treatment may result in a severe clinical course. In our study, we aimed to determine the relationship between the meteorin-like protein (metrnl), which plays a role in the anti-inflammatory balance, and...
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| Format: | Article |
| Language: | English |
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Bilimsel Tip Yayinevi
2023-03-01
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| Series: | Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi |
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| Online Access: | http://www.floradergisi.org/managete/fu_folder/2023-01/2023-28-01-77-86.pdf |
| _version_ | 1811159295464570880 |
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| author | Dursun Erol AFŞİN Esra LALOĞLU |
| author_facet | Dursun Erol AFŞİN Esra LALOĞLU |
| author_sort | Dursun Erol AFŞİN |
| collection | DOAJ |
| description | Introduction: Failure to maintain the inflammatory and anti-inflammatory balance during COVID-19 treatment may result in a severe clinical course. In our study, we aimed to determine the relationship between the meteorin-like protein (metrnl), which plays a role in the anti-inflammatory balance, and the clinical course.
Materials and Methods: Between October 2021 and December 2021, 160 patients who were hospitalized in our hospital and whose delta variant COVID-19 infection was confirmed and 80 healthy controls, were enrolled in the study. Patients were divided into two groups according to the severity degree of COVID-19 (Group 1: Moderate COVID-19, Group 2: Severe COVID-19 MAS).
Results: When comparing the metrnl levels of the groups, it was observed that the metrnl level was statistically significantly lower in Group 2 patients (p< 0.001). While no statistically significant difference was observed between the healthy control group and Group 1, it was observed that the metrnl level of Group 2 patients was statistically significantly lower than the healthy control group (p= 0.77, <0.001 respectively). In the ROC curve analysis of Metrnl level performed in Group 1 and 2 patients, the cut-off value was taken as 17.54 ng/mL, its sensitivity was observed as 80% and the specificity was observed as 60% in predicting the development of severe COVID-19 in patients whose levels were below this value.
Conclusion: The low level of metrnl, which is thought to play a key role in anti-inflammatory balance, contributes to the development of macrophage activation syndrome, which leads to the severe clinical course in COVID-19 patients. |
| first_indexed | 2024-04-10T05:38:37Z |
| format | Article |
| id | doaj.art-3321ceaf30ea4d499c5508daa77955b4 |
| institution | Directory Open Access Journal |
| issn | 1300-932X |
| language | English |
| last_indexed | 2024-04-10T05:38:37Z |
| publishDate | 2023-03-01 |
| publisher | Bilimsel Tip Yayinevi |
| record_format | Article |
| series | Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi |
| spelling | doaj.art-3321ceaf30ea4d499c5508daa77955b42023-03-06T14:31:45ZengBilimsel Tip YayineviFlora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi1300-932X2023-03-01281778610.5578/flora.20239907Could Metrnl be a New Biomarker to Predict the Development of Macrophage Activation Syndrome in COVID-19 Patients?Dursun Erol AFŞİN0https://orcid.org/0000-0002-1185-1535Esra LALOĞLU1https://orcid.org/0000-0001-5189-3564Clinic of Chest Diseases, Erzurum Regional Training and Research Hospital, Erzurum, Türkiye Department of Biochemistry, Atatürk University Faculty of Medicine, Erzurum, TürkiyeIntroduction: Failure to maintain the inflammatory and anti-inflammatory balance during COVID-19 treatment may result in a severe clinical course. In our study, we aimed to determine the relationship between the meteorin-like protein (metrnl), which plays a role in the anti-inflammatory balance, and the clinical course. Materials and Methods: Between October 2021 and December 2021, 160 patients who were hospitalized in our hospital and whose delta variant COVID-19 infection was confirmed and 80 healthy controls, were enrolled in the study. Patients were divided into two groups according to the severity degree of COVID-19 (Group 1: Moderate COVID-19, Group 2: Severe COVID-19 MAS). Results: When comparing the metrnl levels of the groups, it was observed that the metrnl level was statistically significantly lower in Group 2 patients (p< 0.001). While no statistically significant difference was observed between the healthy control group and Group 1, it was observed that the metrnl level of Group 2 patients was statistically significantly lower than the healthy control group (p= 0.77, <0.001 respectively). In the ROC curve analysis of Metrnl level performed in Group 1 and 2 patients, the cut-off value was taken as 17.54 ng/mL, its sensitivity was observed as 80% and the specificity was observed as 60% in predicting the development of severe COVID-19 in patients whose levels were below this value. Conclusion: The low level of metrnl, which is thought to play a key role in anti-inflammatory balance, contributes to the development of macrophage activation syndrome, which leads to the severe clinical course in COVID-19 patients.http://www.floradergisi.org/managete/fu_folder/2023-01/2023-28-01-77-86.pdfcovid-19macrophage activation syndromemetrnl |
| spellingShingle | Dursun Erol AFŞİN Esra LALOĞLU Could Metrnl be a New Biomarker to Predict the Development of Macrophage Activation Syndrome in COVID-19 Patients? Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi covid-19 macrophage activation syndrome metrnl |
| title | Could Metrnl be a New Biomarker to Predict the Development of Macrophage Activation Syndrome in COVID-19 Patients? |
| title_full | Could Metrnl be a New Biomarker to Predict the Development of Macrophage Activation Syndrome in COVID-19 Patients? |
| title_fullStr | Could Metrnl be a New Biomarker to Predict the Development of Macrophage Activation Syndrome in COVID-19 Patients? |
| title_full_unstemmed | Could Metrnl be a New Biomarker to Predict the Development of Macrophage Activation Syndrome in COVID-19 Patients? |
| title_short | Could Metrnl be a New Biomarker to Predict the Development of Macrophage Activation Syndrome in COVID-19 Patients? |
| title_sort | could metrnl be a new biomarker to predict the development of macrophage activation syndrome in covid 19 patients |
| topic | covid-19 macrophage activation syndrome metrnl |
| url | http://www.floradergisi.org/managete/fu_folder/2023-01/2023-28-01-77-86.pdf |
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