TGFβ1 Induces Senescence and Attenuated VEGF Production in Retinal Pericytes

TGFβ1 Induces Senescence and Attenuated VEGF Production in Retinal Pericytes

Diabetic retinopathy (DR) is a microvascular disease of the retina and a serious complication of type I and type II diabetes mellitus. DR affects working-age populations and can cause permanent vision loss if left untreated. The standard of care for proliferative DR is inhibiting VEGF. However, the...

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Bibliographic Details
Main Authors: Dragana Avramovic, Sébastien A. Archaimbault, Alicia M. Kemble, Sabine Gruener, Mirjana Lazendic, Peter D. Westenskow
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Biomedicines
Subjects:
diabetic retinopathy
vascular retinopathy
microvascular disease
pericyte dropout
VEGF
TGFβ1
Online Access:https://www.mdpi.com/2227-9059/10/6/1404

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