The Prostate Cancer Therapy Enzalutamide Compared with Abiraterone Acetate/Prednisone Impacts Motivation for Exploration, Spatial Learning and Alters Dopaminergic Transmission in Aged Castrated Mice

The Prostate Cancer Therapy Enzalutamide Compared with Abiraterone Acetate/Prednisone Impacts Motivation for Exploration, Spatial Learning and Alters Dopaminergic Transmission in Aged Castrated Mice

Cognitive side effects after cancer treatment threatening quality of life (QoL) constitute a major challenge in oncology. Abiraterone acetate plus prednisone (AAP) and enzalutamide (ENZ) are examples of next-generation therapy (NGT) administered to metastatic castration-resistant prostate cancer (mC...

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Bibliographic Details
Main Authors: Celeste Nicola, Martine Dubois, Cynthia Campart, Tareq Al Sagheer, Laurence Desrues, Damien Schapman, Ludovic Galas, Marie Lange, Florence Joly, Hélène Castel
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Cancers
Subjects:
metastatic resistant prostate cancer
enzalutamide
abiraterone acetate/prednisone
aged castrated mice
behavior
dopaminergic pathways
Online Access:https://www.mdpi.com/2072-6694/13/14/3518

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