The effects of electrical stimulation on glial cell behaviour
Abstract Neural interface devices interact with the central nervous system (CNS) to substitute for some sort of functional deficit and improve quality of life for persons with disabilities. Design of safe, biocompatible neural interface devices is a fast-emerging field of neuroscience research. Deve...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-09-01
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| Series: | BMC Biomedical Engineering |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s42490-022-00064-0 |
| _version_ | 1798032541363470336 |
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| author | Christopher T. Tsui Preet Lal Katelyn V. R. Fox Matthew A. Churchward Kathryn G. Todd |
| author_facet | Christopher T. Tsui Preet Lal Katelyn V. R. Fox Matthew A. Churchward Kathryn G. Todd |
| author_sort | Christopher T. Tsui |
| collection | DOAJ |
| description | Abstract Neural interface devices interact with the central nervous system (CNS) to substitute for some sort of functional deficit and improve quality of life for persons with disabilities. Design of safe, biocompatible neural interface devices is a fast-emerging field of neuroscience research. Development of invasive implant materials designed to directly interface with brain or spinal cord tissue has focussed on mitigation of glial scar reactivity toward the implant itself, but little exists in the literature that directly documents the effects of electrical stimulation on glial cells. In this review, a survey of studies documenting such effects has been compiled and categorized based on the various types of stimulation paradigms used and their observed effects on glia. A hybrid neuroscience cell biology-engineering perspective is offered to highlight considerations that must be made in both disciplines in the development of a safe implant. To advance knowledge on how electrical stimulation affects glia, we also suggest experiments elucidating electrochemical reactions that may occur as a result of electrical stimulation and how such reactions may affect glia. Designing a biocompatible stimulation paradigm should be a forefront consideration in the development of a device with improved safety and longevity. |
| first_indexed | 2024-04-11T20:15:42Z |
| format | Article |
| id | doaj.art-332586dcd9a743d5a0004decdb63ae41 |
| institution | Directory Open Access Journal |
| issn | 2524-4426 |
| language | English |
| last_indexed | 2024-04-11T20:15:42Z |
| publishDate | 2022-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Biomedical Engineering |
| spelling | doaj.art-332586dcd9a743d5a0004decdb63ae412022-12-22T04:04:59ZengBMCBMC Biomedical Engineering2524-44262022-09-014111210.1186/s42490-022-00064-0The effects of electrical stimulation on glial cell behaviourChristopher T. Tsui0Preet Lal1Katelyn V. R. Fox2Matthew A. Churchward3Kathryn G. Todd4Neurochemical Research Unit, Department of Psychiatry, University of AlbertaNeurochemical Research Unit, Department of Psychiatry, University of AlbertaNeurochemical Research Unit, Department of Psychiatry, University of AlbertaNeurochemical Research Unit, Department of Psychiatry, University of AlbertaNeurochemical Research Unit, Department of Psychiatry, University of AlbertaAbstract Neural interface devices interact with the central nervous system (CNS) to substitute for some sort of functional deficit and improve quality of life for persons with disabilities. Design of safe, biocompatible neural interface devices is a fast-emerging field of neuroscience research. Development of invasive implant materials designed to directly interface with brain or spinal cord tissue has focussed on mitigation of glial scar reactivity toward the implant itself, but little exists in the literature that directly documents the effects of electrical stimulation on glial cells. In this review, a survey of studies documenting such effects has been compiled and categorized based on the various types of stimulation paradigms used and their observed effects on glia. A hybrid neuroscience cell biology-engineering perspective is offered to highlight considerations that must be made in both disciplines in the development of a safe implant. To advance knowledge on how electrical stimulation affects glia, we also suggest experiments elucidating electrochemical reactions that may occur as a result of electrical stimulation and how such reactions may affect glia. Designing a biocompatible stimulation paradigm should be a forefront consideration in the development of a device with improved safety and longevity.https://doi.org/10.1186/s42490-022-00064-0Neural interfaceMicrogliaAstrocyteOligodendrocyteBiocompatibilityElectrical stimulation |
| spellingShingle | Christopher T. Tsui Preet Lal Katelyn V. R. Fox Matthew A. Churchward Kathryn G. Todd The effects of electrical stimulation on glial cell behaviour BMC Biomedical Engineering Neural interface Microglia Astrocyte Oligodendrocyte Biocompatibility Electrical stimulation |
| title | The effects of electrical stimulation on glial cell behaviour |
| title_full | The effects of electrical stimulation on glial cell behaviour |
| title_fullStr | The effects of electrical stimulation on glial cell behaviour |
| title_full_unstemmed | The effects of electrical stimulation on glial cell behaviour |
| title_short | The effects of electrical stimulation on glial cell behaviour |
| title_sort | effects of electrical stimulation on glial cell behaviour |
| topic | Neural interface Microglia Astrocyte Oligodendrocyte Biocompatibility Electrical stimulation |
| url | https://doi.org/10.1186/s42490-022-00064-0 |
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